Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma

Batistaki, Chrysanthi; Kostopanagiotou, Georgia; Myrianthefs, Pavlos; Dimas, Cleanthi; Matsota, Paraskevi; Pandazi, Aggeliki; Baltopoulos, George

doi:10.1016/j.vph.2007.12.003

Cited by 18 publications

(16 citation statements)

References 33 publications

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“…A catecholamine involvement in exerciseinduced immune changes has also been suggested (Giraldo et al 2009). In fact, recent Wndings of altered cytokine release following catecholamine administration during the early phase after trauma in humans (Batistaki et al 2008) and modulation of IL-6 (that was increased in the present study) release with -adrenergic blockade in septic mice (Schmitz et al 2007) provide further support for catecholamines' involvement in inXammation. Furthermore, epinephrine has been shown to enhance platelet-neutrophil adhesion and adhesion molecule expression (Schmitz et al 2007).…”

Section: Discussionsupporting

confidence: 75%

Physiological and performance adaptations of elite Greco-Roman wrestlers during a one-day tournament

et al. 2010

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The aim of this study was to determine the effects of a simulated one-day Greco-Roman wrestling tournament on selected performance and inflammatory status indices. Twelve competitive wrestlers (22.1 ± 1.3 years) completed five matches according to the official Olympic wrestling tournament regulations following a ~6% weight loss. Performance measurements, muscle damage assessment, and blood sampling were performed before and following each match. Performance and inflammatory markers were not affected by weight loss. Mean wrestling heart rate reached ~85% of maximal and lactate concentration exceeded 17 mM. Fatigue rating demonstrated a progressive rise (P < 0.05) throughout the tournament, peaking in match 4. Performance demonstrated a progressive deterioration (P < 0.05) throughout the tournament, especially in the last two matches (P < 0.05), with upper-body measures exhibiting a greater decline (P < 0.05) and remaining below baseline (P < 0.05) until the end of the tournament. Muscle damage markers increased during the course of the tournament with upper limbs affected more. Creatine kinase activity, CRP levels, IL-6 concentration, and leukocyte counts increased (P < 0.05) progressively throughout the tournament, peaking in the last two matches. Cortisol, epinephrine and norepinephrine increased (P < 0.05) after each match, but testosterone declined (P < 0.05) progressively, reaching a nadir before the last match. This inflammatory response was accompanied by a marked increase (p < 0.05) in lipid peroxidation, protein oxidation, and antioxidant status markers indicating the development of oxidative stress. These results suggest that a one-day wrestling tournament may induce significant physiological demands on wrestlers that may adversely affect their performance and inflammatory status especially during the later stages of the tournament.

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Section: Discussionsupporting

confidence: 75%

Physiological and performance adaptations of elite Greco-Roman wrestlers during a one-day tournament

et al. 2010

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“…[22,23] Contradictory results have been obtained in similar trauma groups, and therefore, results of further studies aiming to clarify the relationships and correlations between thoracic trauma, multiple trauma and IL-10 will be important. [24] In the present study, we found that serum IL-10 values in the HTT and TT groups were significantly higher than those in the C and HT groups at 24 and 48 hours. However, there was no significant increase in the HT group relative to the C group.…”

Section: Discussionsupporting

confidence: 48%

The role of thoracic trauma in inflammatory responses, apoptosis and bacterial translocation following multipl trauma

Ayan¹,

Köksel²,

Polat³

et al. 2013

Ulus Travma Acil Cerrahi Derg

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“…A previous study reported that TNF-α protein expression was detected in significantly high levels in patients with severe trauma (29). Furthermore, NF-κB activity has been shown to be significantly decreased Figure 1.…”

Section: Discussionmentioning

confidence: 86%

“…Therefore, apoptosis induced by TNF-α is regulated by the balance of JNK and NF-κB activation. TNF-α is one of the initial cytokines released during the inflammatory process, and is the main cytokine with an established correlation with trauma (20,21). In addition, the activity of JNK and NF-κB in splenic T cells has been shown to be decreased following trauma-hemorrhage (13,22).…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF-α/NF-κB signaling pathway

Wang

Meng

et al. 2014

Molecular Medicine Reports

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Surgical trauma leads to a severe deterioration of the immune system. Electroacupuncture (EA) may improve the immunodeficiency that occurs following surgery; however, the underlying signaling mechanisms require further study. In the present study, 40 rats were equally randomized into four groups: Control; Control + EA; Trauma; Trauma + EA. EA was applied at the 'Zusanli' (ST36) and 'Lanwei' (Extra37) acupoints, immediately following surgery. The splenic T cells were isolated from the rats 24 h after surgery. The apoptotic rate of the lymphocytes was measured by flow cytometric analysis, and western blotting was used to determine the protein expression levels of caspase-3, caspase-8, tumor necrosis factor (TNF)-α and TNF receptor 1 (TNFR1). The DNA binding activity of nuclear factor (NF)-κB was determined using Trans-AM® ELISA-based kits. The results of the present study showed that surgical trauma induced apoptosis of splenic lymphocytes, and significantly increased the protein expression levels of caspase-3 and caspase-8. This was accompanied by increased expression levels of TNF-α and TNFR1, and a marked reduction in the activity of NF-κB in splenic T cells. Administration of EA significantly decreased the expression levels of caspase-3, caspase-8, TNF-α and TNFR1, elevated the activity of NF-κB, and suppressed the apoptotic rate of the lymphocytes. The data suggests that EA may inhibit the apoptosis of splenic lymphocytes induced by surgical trauma, and ameliorate the postoperative immunosuppression. This may be mediated by the downregulation of TNF-α expression levels and upregulation of the activity of NF-κB.

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Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma

Cited by 18 publications

References 33 publications

Physiological and performance adaptations of elite Greco-Roman wrestlers during a one-day tournament

Physiological and performance adaptations of elite Greco-Roman wrestlers during a one-day tournament

The role of thoracic trauma in inflammatory responses, apoptosis and bacterial translocation following multipl trauma

Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF-α/NF-κB signaling pathway

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