Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials

Fedewa, Michael V.; Hathaway, Elizabeth D.; Ward-Ritacco, Christie L.

doi:10.1136/bjsports-2016-095999

Cited by 217 publications

(170 citation statements)

References 123 publications

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“…A number of intervention studies have shown the effect of physical activity on improving biomarkers of inflammation and insulin . These intervention studies support the causal relationship between physical activity and the biomarkers, supporting the basis of our study.…”

Section: Discussionsupporting

confidence: 88%

“…However, the influence of specific components of physical activity (e.g., volume, intensity and type) on these biomarkers remains unclear . Moreover, the majority of previous studies were small and restricted to unhealthy populations with diseases …”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest that physical activity may also have direct effects on biomarkers of inflammation and insulin response, regardless of reductions in body fatness . It is particularly important to determine the amount of total physical activity associated with a healthy biomarker profile, both mediated through and independent of body fatness.…”

Section: Introductionmentioning

confidence: 99%

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Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response

Lee

Rezende

Eluf‐Neto

et al. 2019

Intl Journal of Cancer

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Several biological mechanisms linking physical activity with cancer have been proposed. However, the influence of specific components of physical activity (volume, type and intensity), and their interaction with adiposity and diet, on cancer‐related biomarkers remain unclear. We used cross‐sectional data on 7,219 men in the Health Professionals Follow‐up Study (1992–1994) with C‐reactive protein (CRP), interleukin‐6 (IL6), tumor necrosis factor alpha receptor 2 (TNFαR2), adiponectin, C‐peptide and triglycerides/high‐density lipoprotein cholesterol ratio (TG/HDL). Details on physical activity, diet and adiposity were assessed by questionnaires. We used multivariable‐adjusted linear regression analyses to estimate relative concentrations of biomarkers by physical activity. Total physical activity was favorably associated with all biomarkers in a fairly linear manner. Comparing the highest (63+ metabolic equivalent (MET)‐hr/week) to the lowest (0‐8.9 MET‐hr/week) physical activity groups, the percent relative difference in concentration of biomarkers was −31% for CRP, −22% for IL6, −8% for TNFαR2, +9% for adiponectin, −22% for C‐peptide, and −20% for TG/HDL. These differences were modestly attenuated after adjustment for adiposity. For the same total MET‐hours of physical activity, the association was stronger for men engaging in both aerobic and resistance exercises compared to those engaging in aerobic only. However, no difference was found between those engaging in vigorous activities (≥20% of total MET‐hours) compared to those who did smaller amount of vigorous activities. Physical activity showed similar associations for these biomarkers regardless of adiposity and dietary pattern. In conclusion, high physical activity, preferably aerobic plus resistance training, was associated with favorable cancer‐related biomarkers.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response

Lee

Rezende

Eluf‐Neto

et al. 2019

Intl Journal of Cancer

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“…Individuals with knee OA have higher levels of circulating cartilage‐derived biomarkers compared to healthy controls . Systematic reviews that included overweight and normal‐weight youth and adult participants, with or without cardiovascular diseases , have shown a beneficial effect of exercise on reducing the C‐reactive protein (CRP) level, a molecular biomarker related to systemic inflammation also involved in OA progression. In the OA population, individual studies indicate that single bouts of exercise therapy promote immediate changes to molecular biomarkers related to cartilage extracellular matrix turnover (e.g., cartilage oligomeric matrix protein [COMP]) and inflammation (e.g., interleukin‐10 [IL‐10]) that, in general, return to baseline levels after a short period of rest .…”

Section: Introductionmentioning

confidence: 99%

Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Struglics

Larsson

Steultjens

et al. 2019

Arthritis Care & Research

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Objective. To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in individuals at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).Methods. We conducted a literature search up to September 2017 in 5 major databases with no restriction on publication year or language. Data were extracted from the first available follow-up time point, and we performed a narrative synthesis for the effect of exercise therapy on molecular biomarkers related to cartilage and inflammation. A subset of studies reporting sufficient data was combined in a meta-analysis, using an adjusted random-effects model.Results. Twelve RCTs involving 57 study comparisons at 4 to 24 weeks following an exercise-therapy intervention were included. Exercise therapy decreased molecular biomarkers in 17 study comparisons (30%), had no effect in 36 (63%), and increased molecular biomarkers in 4 study comparisons (7%). Meta-analyses of 9 biomarkers showed that exercise therapy was associated with nonsignificant reductions of the C-reactive protein level, Cterminal crosslinking telopeptide of type II collagen, tumor necrosis factor (TNF), soluble TNF receptors 1 and 2, C2C neoepitope of type II collagen, and cartilage oligomeric matrix protein, compared to nonexercising control groups, and exercise therapy had no effect on interleukin-6 and soluble interleukin-6 receptor.Conclusion. Exercise therapy is not harmful, because it does not increase the concentration of molecular biomarkers related to cartilage turnover and inflammation, implicated in osteoarthritis progression. The overall quality of evidence was downgraded to low because of the limited number of RCTs available.

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“…There is also evidence that physical activity interventions, including aerobic exercise and strength training, can reduce markers of peripheral inflammation. One recent review of 83 randomized and non‐randomized trials found an overall reduction in CRP following physical activity, albeit with a small effect size (Fedewa, Hathaway, & Ward‐Ritacco, ). Other reviews have demonstrated similar effects of exercise within specific patient populations such as breast cancer survivors (Meneses‐Echavez et al, ), patients with type 2 diabetes (Hayashino et al, ), and older adults (Sardeli et al, ).…”

Section: Healthy Behaviors and The Neuro‐immune Networkmentioning

confidence: 99%

Cultivating a healthy neuro‐immune network: A health psychology approach

Bower

Kuhlman

Haydon

et al. 2019

Social & Personality Psych

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The field of psychoneuroimmunology (PNI) examines interactions among psychological and behavioral states, the brain, and the immune system. Research in PNI has elegantly documented effects of stress at multiple levels of the neuro‐immune network, with profound implications for both physical and mental health. In this review, we consider how the neuro‐immune network might be influenced by “positive” psychological and behavioral states, focusing on positive affect, eudaimonic well‐being, physical activity, and sleep. There is compelling evidence that these positive states and behaviors are associated with changes in immune activity in the body, including reductions in peripheral inflammatory processes relevant for physical health. Growing evidence from animal models also suggests effects of positive states on immune cells in the brain and the blood‐brain barrier, which then impact critical aspects of mood, cognition, and behavior. Tremendous advances are being made in our understanding of neuro‐immune dynamics; one of the central goals of this review is to highlight recent preclinical research in this area and consider how we can leverage these findings to investigate and cultivate a healthy neuro‐immune network in humans.

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Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials

Abstract: These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.

Cited by 217 publications

References 123 publications

Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response

Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response

Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Cultivating a healthy neuro‐immune network: A health psychology approach

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