Effect of exercise training on oxidative stress and mitochondrial function in rat heart and gastrocnemius muscle

Farhat, Firas; Dupas, Julie; Amérand, Aline; Goanvec, Christelle; Feray, Annie; Simon, Bernard; Guegueniat, Nathalie; Moisan, C.

doi:10.1179/1351000214y.0000000105

Cited by 25 publications

(30 citation statements)

References 46 publications

(53 reference statements)

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“…Apart from those given in Table 1, the results on male rats were previously published [16]. These data on male rats are given for comparison with female rats.…”

Section: Resultsmentioning

confidence: 99%

“…To compare the results of female rats with the male rats studied in Farhat et al [16], the methods used are the same as those in this previous paper.…”

Section: Methodsmentioning

confidence: 99%

“…In contrast, Liu et al [15] reported that 8 weeks of moderate running training in Sprague-Dawley rats resulted in greater increases of lipid peroxidation in the skeletal muscle of female rats than in male ones. In a recent study, Farhat et al [16] reported that moderate training (running 60 minutes/day, 5 days/week for 6 weeks, 70% of V max ) improved mitochondrial function and changed the susceptibility of mitochondrial function to in vitro ROS exposure in the skeletal muscle of male Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

“…To achieve this, we used the same moderate exercise training protocol in female Wistar rats as Farhat et al [16] used in male rats. To the best of our knowledge, this is the first study to explore both hypothetical gender and training differences in the mitochondrial function of rat skeletal muscle and its susceptibility to in vitro ROS exposure.…”

Section: Introductionmentioning

confidence: 99%

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Gender-dependent differences of mitochondrial function and oxidative stress in rat skeletal muscle at rest and after exercise training

et al. 2017

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Objective: This study investigated gender-dependent differences of mitochondrial function and sensitivity to in vitro ROS exposure in rat skeletal muscle at rest and after exercise training. Methods: Wistar rats underwent running training for 6 weeks. In vitro measurements of hydroxyl radical production, oxygen consumption (under basal and maximal respiration conditions) and ATP production were made on permeabilized fibers. Mitochondrial function was examined after exposure and non-exposure to an in vitro generator system of reactive oxygen species (ROS). Antioxidant enzyme activities and malondialdehyde (MDA) content were also determined. Results: Compared with sedentary males, females showed a greater resistance of mitochondrial function (oxygen consumption and ATP production) to ROS exposure, and lower MDA content and antioxidant enzyme activities. The training protocol had more beneficial effects in males than females with regard to ROS production and oxidative stress. In contrast to male rats, the susceptibility of mitochondrial function to ROS exposure in trained females was unchanged. Discussion: Exercise training improves mitochondrial function oxidative capacities in both male and female rats, but is more pronounced in males as a result of different mechanisms. The resistance of mitochondrial function to in vitro oxidative stress exposure and the antioxidant responses are gender-and training-dependent, and may be related to the protective effects of estrogen.

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“…Apart from those given in Table 1, the results on male rats were previously published [16]. These data on male rats are given for comparison with female rats.…”

Section: Resultsmentioning

confidence: 99%

“…To compare the results of female rats with the male rats studied in Farhat et al [16], the methods used are the same as those in this previous paper.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gender-dependent differences of mitochondrial function and oxidative stress in rat skeletal muscle at rest and after exercise training

et al. 2017

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“…Farhat et al indicated that 6 weeks of running on treadmill reduces the production of free OH radicals (11). Yoshida et al also observed that 27 sessions of concurrent training (5 days per week) in patients with cardiovascular diseases reduced oxidative stress through increasing antioxidant capacity (7).…”

Section: Discussionmentioning

confidence: 99%

The rehabilitation training and antioxidant status in patients with myocardial infarction

Parsa

Saki

Ebrahim

et al. 2017

JBRMS

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Introduction: Myocardial infarction (MI) is associated with increased oxidative stress and reduced antioxidants. Some studies have shown that exercise training increases the serum level antioxidants. Therefore, this study investigated the effect of rehabilitation training on antioxidant status in patients with myocardial infarction. Materials and methods: In this study, 20 patients with myocardial infarction were selected and randomly assigned to training group (n=10) or control group (n=10). Training program included 3 sessions of concurrent training per week for eight consecutive weeks. To measure the values of malondialdehyde (MDA), protein carbonylation (PC) and total antioxidant capacity (TAC), 10 ml of blood were taken pre-and post-training in each patient. The t-test was used to analyze the data. P<0.05 was considered significant in all tests. Results: The data showed that 8 weeks of rehabilitation training significantly reduces MDA (2.37±0.59 µM and 3.74±1.34 µM in training and control groups, respectively; P=0.000) and PC (9.15±1.77 nmol/mg protein and 11.48±1.60 nmol/mg protein in training and control groups, respectively; P=0.006) levels and significantly increases TAC (10.09±1.70 U/ml and 8.34±1.56 U/ml in training and control groups, respectively; P=0.031). Conclusion: Since the findings of the present study show a reduction in oxidative stress markers (MDA, PC) and an increase in total antioxidants capacity, it seems that eight weeks of concurrent training may improve the antioxidant capacity in patients after myocardial infarction.

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Exercise training changes mitochondrial function and its vulnerability to reactive oxygen species exposure differently in male and female silver European eels

et al. 2020

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Effect of exercise training on oxidative stress and mitochondrial function in rat heart and gastrocnemius muscle

Cited by 25 publications

References 46 publications

Gender-dependent differences of mitochondrial function and oxidative stress in rat skeletal muscle at rest and after exercise training

Gender-dependent differences of mitochondrial function and oxidative stress in rat skeletal muscle at rest and after exercise training

The rehabilitation training and antioxidant status in patients with myocardial infarction

Exercise training changes mitochondrial function and its vulnerability to reactive oxygen species exposure differently in male and female silver European eels

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