Effect of exercise training in rats exposed to chronic hypoxia: Application for Monge’s disease

Sub‐maximal aerobic exercise training reduces haematocrit and ameliorates symptoms in Andean highlanders with chronic mountain sickness

“…Overall, despite ET‐induced increased RBCV, plasma expansion overrides any increase in red blood cell mass and results in reduced haematocrit. In the case of CMS highlanders this reduction can be magnified by ET‐induced mechanical haemolysis due to excessive haematocrit levels (Macarlupu et al., 2021 ; Telford et al., 2003 ). In fact, we have recently shown that haemolysis might be an additional mechanism for ET‐induced haematocrit reduction in a rat model of high‐altitude erythrocytosis (Macarlupu et al., 2021 ).…”

“…In the case of CMS highlanders this reduction can be magnified by ET‐induced mechanical haemolysis due to excessive haematocrit levels (Macarlupu et al., 2021 ; Telford et al., 2003 ). In fact, we have recently shown that haemolysis might be an additional mechanism for ET‐induced haematocrit reduction in a rat model of high‐altitude erythrocytosis (Macarlupu et al., 2021 ). Haemolysis due to mechanical stress might lead to a reduction in haematocrit without significant modification of PV or total blood volume (Schobersberger et al., 1990 ; Selby & Eichner, 1986 ; Telford et al., 2003 ).…”

“…• What is the main finding and its importance? haematocrit in a rat model of chronic hypoxia-induced erythrocytosis mainly due to exercise-induced haemolysis without changes in plasma volume (Macarlupu et al, 2021).…”

“…( 2005 ) have shown that native high‐altitude athletes living and training above 4000 m have sea‐level Hb concentrations in contrast to sedentary individuals living at the same altitude. Moreover, a recent study by our group has shown that exercise training (ET) reduces haematocrit in a rat model of chronic hypoxia‐induced erythrocytosis mainly due to exercise‐induced haemolysis without changes in plasma volume (Macarlupu et al., 2021 ).…”