Effect of exercise on renal function in diabetic nephropathy—a systematic review and meta-analysis

Nataraj, Megha; Maiya, Arun G; Nagaraju, Shankar Prasad; Shastry, BA; Shivashankara, KN

doi:10.1016/j.jtumed.2022.11.002

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…The text poses the topic of whether screening for early nephropathy symptoms should be done in order to allow for prompt intervention [16]. The importance of the renin-angiotensin system (RAS) blockade treatment is emphasized because it is specifically started after the development of chronic albuminuria [11].…”

Section: Discussionmentioning

confidence: 99%

“…It is distinguished by a decrease in protein in the urine. Renal impairment progresses in these people from a slight functional drop to mild, moderate, or severe nephron loss [11]. Diabetic neuropathy leads to severe illness and a decline in sensory function that initiates in the lower limbs and is accompanied by discomfort [12].…”

Section: Introductionmentioning

confidence: 99%

“…Age, male sex, longterm diabetes, early hyperfiltration indicated by an estimated glomerular filtration rate (GFR) (90 mL/min/1.73 m2), a systolic blood pressure greater than 130 mmHg, and chronic proteinuria with concomitant retinopathy are risk factors for DN and its progression. People's quality of life, ability to work physically, and frailty are all negatively impacted when they experience weariness, discomfort, dyspnea, sarcopenia, and renal anaemia [11].…”

Section: Introductionmentioning

confidence: 99%

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Physiotherapeutic Approach for Paraparesis Resulting From L2-S1 Disc Bulge Along With Diabetic Neuropathy: A Case Report

Rajurkar,

Harjpal,

Tikhile

2024

Cureus

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A degenerative disc disease is characterized by osteophytes, disc space reduction, nerve compression and discomfort are all symptoms of disc bulging. Diabetic neuropathy, a condition leading to significant health issues, involves a sensory dysfunction initiating in the lower extremities and progressing to pain. In the present case, a 61-year-old retired physical training teacher came to the hospital with complaints of difficulty in walking, sitting, and standing in the past two years. The patient also complained of a tingling sensation in the upper and lower limbs, low back pain, and body stiffness. The patient has a known case of intervertebral disc prolapse at L2-S1 level, two years back. Patient had a history of diabetes mellitus type 2, hypertension, and hypothyroidism for the past three years. The study delves into the detailed evaluation, customized treatment plan, and rehabilitation strategies employed to meet the patient's condition. It emphasizes the value of a multidisciplinary approach, including physical therapy, in the treatment of complicated musculoskeletal and neurological illnesses, intending to improve the patient's mobility, functionality, and overall quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physiotherapeutic Approach for Paraparesis Resulting From L2-S1 Disc Bulge Along With Diabetic Neuropathy: A Case Report

Rajurkar,

Harjpal,

Tikhile

2024

Cureus

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“…Diabetes, Metabolic Syndrome and Obesity 2023:16 3674 topic, those available have shown how home training can determine decreased urinary albumin-to-creatinine ratio, serum urea nitrogen, urinary protein-to-creatinine ratio, and urinary protein excretion. 112 However, diet and lifestyle seem ineffective on other renal function outcomes (eg eGFR) and the sample size across randomized controlled trials is quite small. As a consequence and as limitations of studies, it is hard to identify subjects with different responses to the same interventions, thus the authors argue that in the future, new trials with large sample sizes will be required to better define the role of lifestyle in populations with diabetic nephropathy.…”

Section: Dovepressmentioning

confidence: 99%

Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations

Galiero,

Caturano,

Vetrano

et al. 2023

DMSO

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Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases in Western countries, and its incidence is constantly increasing. Epidemiological studies have shown that in the next 20 years. The number of subjects affected by T2DM will double. In recent years, owing to the development and improvement in methods for studying the genome, several authors have evaluated the association between monogenic or polygenic genetic alterations and the development of metabolic diseases and complications. In addition, sedentary lifestyle and socio-economic and pandemic factors have a great impact on the habits of the population and have significantly contributed to the increase in the incidence of metabolic disorders, obesity, T2DM, metabolic syndrome, and liver steatosis. Moreover, patients with type 2 diabetes appear to respond to antihyperglycemic drugs. Only a minority of patients could be considered true non-responders. Thus, it appears clear that the main aim of precision medicine in T2DM is to identify patients who can benefit most from a specific drug class more than from the others. Precision medicine is a discipline that evaluates the applicability of genetic, lifestyle, and environmental factors to disease development. In particular, it evaluated whether these factors could affect the development of diseases and their complications, response to diet, lifestyle, and use of drugs. Thus, the objective is to find prevention models aimed at reducing the incidence of pathology and mortality and therapeutic personalized approaches, to obtain a greater probability of response and efficacy. This review aims to evaluate the applicability of precision medicine for T2DM, a healthcare burden in many countries.

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Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial

Nataraj,

Maiya,

Nagaraju

et al. 2024

Int Urol Nephrol

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Introduction Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy. Methods A total of 283 individuals were screened and 60 eligible participants aged 45–70 years with diabetic nephropathy were randomly allocated (n = 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week. Results The repeated measures ANOVA with Greenhouse–Geisser correction indicated significant timepoint*group interaction effect for 6-min walk distance F (1.71, 90.59) = 619, p < 0.001, serum creatinine F (1.23, 65.14) = 174.8, p < 0.001, estimated glomerular filtration rate F(1.15, 60.88) = 105.2, p < 0.001, serum urea F(1.48, 78.45) = 261.4, p < 0.001 and urine protein F (1.13, 59.82) = 4.58, p < 0.328. Conclusion The study found that exercise based rehabilitation improved both functional capacity and renal function among individuals with type 2 diabetic nephropathy.

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Effect of exercise on renal function in diabetic nephropathy—a systematic review and meta-analysis

Cited by 3 publications

References 43 publications

Physiotherapeutic Approach for Paraparesis Resulting From L2-S1 Disc Bulge Along With Diabetic Neuropathy: A Case Report

Physiotherapeutic Approach for Paraparesis Resulting From L2-S1 Disc Bulge Along With Diabetic Neuropathy: A Case Report

Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations

Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial

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