Effect of exercise on protein degradation: 3-Methylhistidine and creatinine excretion

Radha, E.; Bessman, Samuel P.

doi:10.1016/0006-2944(83)90058-3

Cited by 23 publications

(12 citation statements)

References 15 publications

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“…The results shown in Figure 1 were the first direct evidence that there is an increase in muscle protein breakdown after exercise. Although some previous studies had derived this conclusion from an increase in the rate of excretion of 3‐methylhistidine (Rennie et al 1981, Dohm et al 1982, 1985), others found no change (Plante & Houston 1984a,b, Carraro et al 1990a), or decreased (Radha & Bessman 1983, Dohm et al 1985, Mussini et al 1985) excretion of 3‐methylhistidine in response to exercise. Thus, using whole body and 3‐methylhistidine techniques to measure protein breakdown gives a less than clear picture of the response of protein breakdown to exercise.…”

Section: Methodsmentioning

confidence: 94%

Exercise‐induced changes in protein metabolism

Tipton

Wolfe

1998

Acta Physiologica Scandinavica

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Exercise has a profound acute effect on protein metabolism. Whereas reports on whole body responses to exercise have varied results, it is generally agreed leucine oxidation is increased during exercise, thus indicating increased net protein breakdown. Following endurance exercise, whole body protein breakdown is generally reduced from resting levels, while following eccentric exercise, both whole body protein breakdown and leucine oxidation are increased. Whole body protein synthesis, on the other hand, is either increased or unchanged. Much of the disagreement in the results of studies on the response of whole body protein metabolism to exercise may be attributed to the limitations of the available methods. Even if the methodology accurately reflects whole body metabolism, this may not reflect changes in the protein metabolism of muscle. Although endurance exercise has not been studied, muscle protein breakdown is increased following resistance exercise. There is a concomitant, and qualitatively greater, increase in muscle protein synthesis following resistance exercise, which may last for as long as 48 h. Increased muscle protein synthesis is linked to increased intramuscular availability of amino acids, and thus, to increased blood flow and increased amino acid delivery to the muscle, as well as increased amino acid transport. Administration of exogenous amino acids after exercise increases protein synthesis while ameliorating protein breakdown, thus improving net muscle protein balance. While it is clear that muscle protein synthesis and protein breakdown increase in a qualitatively similar manner following exercise, the mechanisms of stimulation have yet to be determined. However, we propose that the intracellular availability of amino acids is the link between these processes.

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Section: Methodsmentioning

confidence: 94%

Exercise‐induced changes in protein metabolism

Tipton

Wolfe

1998

Acta Physiologica Scandinavica

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“…The impact of exercise (or conversely hypokinesia) has been suggested to affect creatinine metabolism in humans although not uniformly. Studies have reported that intensive exercise reduces creatinine excretion, 23 whilst others have shown the opposite 24 or no significant effect 25 . Reports detailing the amount of regular exercise and day‐to‐day physical activity levels in PDD are sparse at present, although a high comorbidity rate with activity‐related disorders such as Attention Deficit Hyperactivity Disorder (ADHD) 26 would suggest that at least in a proportion of cases, activity levels will be high.…”

Section: Discussionmentioning

confidence: 99%

Spot urinary creatinine excretion in pervasive developmental disorders

Whiteley¹,

Waring²,

Williams³

et al. 2006

Pediatrics International

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Further studies of protein catabolism and renal function in autism are required to ascertain the relevance of decreased spot urinary creatinine excretion identified in this preliminary study. Issues regarding the use of single urine creatinine measurements and associated confounding variables are discussed in light of the findings, together with recommendations to use other internal or external standards for the quantification of urinary compounds in PDD research.

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“…The ratio of pesticide or pesticide metabolite clearance to Cn clearance may also be affected by these same conditions. For example, Radha and Bessman (1983) studied the effect of a 1-h intensive exercise on young males placed on a meat-free diet. Immediately following the exercise, Cn excretion rates decreased significantly.…”

Section: Estimating the Dose Of A Pesticidementioning

confidence: 99%

Estimating pesticide dose from urinary pesticide concentration data by creatinine correction in the Third National Health and Nutrition Examination Survey (NHANES-III)

Mage

Allen

Gondy

et al. 2004

J Expo Sci Environ Epidemiol

143

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The Third National Health and Nutrition Examination Survey (NHANES-III) of the Centers for Disease Control and Prevention (CDC) recorded data on the urinary concentrations of 12 chemicals (analytes), which were either pesticides or their metabolites, that represent exposure to certain pesticides, in urine samples collected from 1988 to 1994 from a cohort of 978 volunteer subjects, aged 20-59 years. We have used each subject's urinary creatinine concentration and their individual daily creatinine excretion rate (g/day) computed from their age, gender, height and weight, to estimate their daily excretion rate in mg analyte/kg/day. We discuss the mechanisms of excretion of the analytes and certain assumptions needed to compute the equivalent daily dietary intake (mg/kg/day) of the most likely parent pesticide compounds for each excreted analyte. We used literature data on the average amount of parent compound ingested per unit amount of the analyte excreted in the urine, and compared these estimated daily intakes to the US EPA's reference dose (RfD) values for each of those parent pesticides. A Johnson S B distribution (four-parameter lognormal) was fit to these data to estimate the national distribution of exclusive exposures to these 12 parent compounds. Only three such pesticides had a few predicted values above their RfD (lindane 1.6%; 2,4-dichlorophenol 1.3%; chlorpyrifos 0.02%). Given the possibility of a subject's dietary intake of a pesticide's metabolites incorporated into treated food, our results show that few, if any, individuals in the general US population aged 20-59 years and not employed in pesticide application were likely to have exceeded the USEPA RfD for these parent compounds during the years studied.

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Effect of exercise on protein degradation: 3-Methylhistidine and creatinine excretion

Cited by 23 publications

References 15 publications

Exercise‐induced changes in protein metabolism

Exercise‐induced changes in protein metabolism

Spot urinary creatinine excretion in pervasive developmental disorders

Estimating pesticide dose from urinary pesticide concentration data by creatinine correction in the Third National Health and Nutrition Examination Survey (NHANES-III)

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