Effect of exercise on plasma paraoxonase1 activity in rugby players: Dependance on training experience

Otocka-Kmiecik, Aneta; Bortnik, Krzysztof; Szkudlarek, Urszula; Nowak, Dariusz; Orłowska-Majdak, M

doi:10.1179/1351000213y.0000000047

Cited by 14 publications

(22 citation statements)

References 30 publications

(31 reference statements)

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“…Biochemical parameters did not differ between groups either at rest or at ME. These values are very similar to those obtained in our previous studies [ 9 , 10 ]. However, there has been some tendency (but no statistically significant difference) to a higher antioxidant defense (higher FRAP, UA, and TBil) and lower lipid oxidation (lower TBARS), as well as a more favorable lipid profile (lower TChol, LDL-C, and TG and higher HDL-C) in the PA group ( Table 2 ).…”

Section: Discussionsupporting

confidence: 92%

“…In our study both FRAP and UA continued to rise 2 hours after ME. Similar results on UA changes were described in other studies [ 9 , 10 , 20 ]. Additionally, Yanai and Morimoto (2004) found that the serum urate levels were significantly elevated even 3 weeks after exhaustive training [ 21 ].…”

Section: Discussionsupporting

confidence: 91%

“…Physical activity was found to modulate PON1 concentration and/or activity [ 8 ]. Our previous findings show that physical exercise affects PON1 activity [ 9 , 10 ]. Yet, some researchers do not confirm these observations [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Aerobic Training Modulates the Effects of Exercise-Induced Oxidative Stress on PON1 Activity: A Preliminary Study

Otocka-Kmiecik

Lewandowski²,

Szkudlarek

et al. 2014

The Scientific World Journal

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The aim of the study was to compare the effect of maximal exercise (ME) on paraoxonase (PON) and arylesterase (ARE) activity depending on lifestyle in respect to physical activity. The study was performed on 46 young men divided into two groups: sedentary (S) and physically active (PA). All participants performed ME on a treadmill. PON1 activities, FRAP, uric acid, bilirubin, TBARS, and lipid profile were determined in their blood before, at the bout of, and after ME. No significant differences in PON1 activities were found between S and PA subjects at baseline. Nearly all biochemicals increased at ME in both groups. Both PON and ARE activity increased at the bout of ME in PA subjects and only ARE activity in S subjects. ARE/HDL-C ratio increased at the bout of ME in PA and S subjects. The difference in PON1 activity response to ME between study groups may be a result of adaptation of PA subjects to regular physical activity. We suggest that PON1 activity may be a marker of antioxidant protection at ME and an indicator of adaptation to exercise.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

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Aerobic Training Modulates the Effects of Exercise-Induced Oxidative Stress on PON1 Activity: A Preliminary Study

Otocka-Kmiecik

Lewandowski²,

Szkudlarek

et al. 2014

The Scientific World Journal

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“…In another study, after maximal exercise (ME), an increase in PON1 activities was found; however, no changes in AE activity were found in trained rugby players. PON1 changes during ME were dependent on age, body composition, and training experience as different from the present study, although the influence of PON1P on PON1 changes at ME was uncertain 49) . In the present study, PON1P was not related to the effects of exercise training on AE activity.…”

Section: Correlations Among Variablescontrasting

confidence: 50%

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay

Şişman

Aksu

2015

JAT

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Aim: Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL). The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including basal PON1, salt-stimulated PON1 (SPON1), and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P). Methods: Our study included 18 Turkish national female judoists (mean age: 17.9 0.8 years). Before and after 5 months of anaerobic training, critical speed (CS), TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG; persons with low activity) and R carriers (QR RR) (RG; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P ≤ 0.05. Results: Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. Conclusions: Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs -C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research. J Atheroscler Thromb, 2015; 22: 313-326.

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“…Exercise is another major factor that affects PON1 activity. 9 , 12 , 13 Therefore, to protect against CVD, it is important to monitor one's serum PON1 and HDLs-ARE activities as well as cholesterol levels, with the goal of improving these activities through an appropriate exercise program.…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

Nalçakan

Varol

Turgay

et al. 2016

Journal of Sport and Health Science

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BackgroundParaoxonase 1 (PON1) is an antioxidant enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein against oxidation. Limited studies have addressed the influence of exercise on PON1 activity and its relationship with PON1 phenotypes. We investigated relationships between PON1-192 phenotypes, PON1 activity, aerobic exercise, and blood lipid and lipoprotein concentrations in middle-aged women.MethodsAn exercise group (n = 50) engaging in regular aerobic exercise and a control group (n = 41) were selected from a subset of 300 Caucasian women that met the inclusion criteria. Serum PON1, salt-stimulated PON1 (SSPON1), and arylesterase (ARE) activities; cholesterol levels and ARE activities of total HDL and HDL subgroups (HDLs) (supernatants obtained by polyethylene glycol); and blood lipid and lipoprotein concentrations were determined by standardized enzymatic methods. PON1-192 QQ (low activity), QR (moderate activity), and RR (high activity) phenotype groups were defined using serum SSPON1/ARE activity ratios. The R-carries (RC) phenotype group consisted of the QR and RR groups combined.ResultsAll lipid and lipoprotein concentrations were greater in the exercise group than in the control group. Regardless of phenotype, no significant differences were observed between the exercise and control groups in terms of serum PON1, SSPON1, or ARE activity associated with HDLs (p > 0.05), whereas PON1 activities in QQ-phenotyped women in the exercise group were significantly higher than those in the control group (p < 0.01), but not the RC group. A statistically significant interaction between PON1 phenotypes (QQ and RC groups) and exercise (exercise and control groups) on PON1 activity was found.ConclusionThese results showed that a regular aerobic exercise program can improve PON1 activity depending on PON1-192 phenotype, but not on lipid and lipoprotein levels, in middle-aged Turkish women.

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Effect of exercise on plasma paraoxonase1 activity in rugby players: Dependance on training experience

Abstract: We conclude that in rugby players PON1 changes during ME depend on age, body composition, and training experience. The influence of PON1 Q192R polymorphism on PON1 changes at ME remains debatable.

Cited by 14 publications

References 30 publications

Aerobic Training Modulates the Effects of Exercise-Induced Oxidative Stress on PON1 Activity: A Preliminary Study

Aerobic Training Modulates the Effects of Exercise-Induced Oxidative Stress on PON1 Activity: A Preliminary Study

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women

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