Effect of exercise on endothelial function in heart transplant recipients: systematic review and meta-analysis

Souza, Juliana Andrade Ferreira de; Araújo, Bruna Thays Santana de; Lima, Gustavo Henrique Correia de; Andrade, Armèle Dornelas de; Campos, Shirley Lima; Aguiar, Maria Inês Remígio de; Carneiro, Rodrigo Moreno Dias; Brandão, Daniella Cunha

doi:10.1007/s10741-019-09877-z

Cited by 6 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2020, de Souza et al 15 investigated the effect of moderate-intensity continuous training (MICT) compared with HIIT on endothelial function in a systematic review and meta-analysis. Four studies were included.…”

Section: A Summary Of the Seven Reviews And Meta-analyses (≥2015) Inc...mentioning

confidence: 99%

“…The review included nine studies published from 2017-2021 and concluded that HIIT was generally superior or similar to other exercise modalities on V ˙O2peak and a majority of other secondary outcomes. Only two of the nine studies reported effects of HIIT after HTx, which showed Anderson et al (2017) 13 • The results showed that 8-12 wk of CR with HIIT was sufficient to significantly increase HR peak and CRF of recipients of HTx (men and women) de Souza et al (2020) 15 4 The marked studies (n = 15) are included in two or more of the seven systematic reviews/meta-analyses presented.…”

Section: A Summary Of the Seven Reviews And Meta-analyses (≥2015) Inc...mentioning

confidence: 99%

See 1 more Smart Citation

A Review of High-Intensity Interval Training in Heart Transplant Recipients

Nytrøen,

Rolid

2024

Journal of Cardiopulmonary Rehabilitation and Prevention

View full text Add to dashboard Cite

Objective: This review reports how exercise-based rehabilitation strategies have developed over the past decades, and it specifically focuses on the effectiveness, safety, and implementation of high-intensity interval training (HIIT). It provides an overview of the historical progression, main research findings, and considerations surrounding HIIT as the preferred exercise modality for recipients of heart transplant (HTx). Review Methods: The review includes a timeline of studies spanning from 1976-2023. The 2017 Cochrane systematic review on exercise-based cardiac rehabilitation in recipients of HTx serves as the main knowledge base (≥2015). Additionally, literature searches in PubMed/Medline and ClinicalTrials.gov have been performed, and all reviews and studies reporting the effects of moderate- to high-intensity exercise in recipients of HTx, published in 2015 or later have been screened. Summary: High-intensity interval training has gained prominence as an effective exercise intervention for recipients of HTx, demonstrated by an accumulation of performed studies in the past decade, although implementation in clinical practice remains limited. Early restrictions on HIIT in HTx recipients lacked evidence-based support, and recent research challenges these previous restrictions. High-intensity interval training results in greater improvements and benefits compared with moderate-intensity continuous training in the majority of studies. While HIIT is now regarded as generally suitable on a group level, individual assessment is still advised. The impact of HIIT involves reinnervation and central and peripheral adaptations to exercise, with variations in recipent responses, especially between de novo and maintenance recipients, and also between younger and older recipients. Long-term effects and mechanisms behind the HIIT effect warrant further investigation, as well as a focus on optimized HIIT protocols and exercise benefits.

show abstract

Section: A Summary Of the Seven Reviews And Meta-analyses (≥2015) Inc...mentioning

confidence: 99%

Section: A Summary Of the Seven Reviews And Meta-analyses (≥2015) Inc...mentioning

confidence: 99%

A Review of High-Intensity Interval Training in Heart Transplant Recipients

Nytrøen,

Rolid

2024

Journal of Cardiopulmonary Rehabilitation and Prevention

View full text Add to dashboard Cite

show abstract

“…Exercise training, as early as possible after hospital discharge, is being considered beneficial for the acute and long-term outcomes of heart transplant patients[ 83 - 86 ]. It has been shown to improve endothelial function assessed by brachial artery flow-mediated dilatation (FMD)[ 79 ].…”

Section: Cardiac Rehabilitation In Heart Transplantationmentioning

confidence: 99%

Exercise training in heart transplantation

Kourek¹,

Karatzanos²,

Nanas³

et al. 2021

WJT

View full text Add to dashboard Cite

Heart transplantation remains the gold standard in the treatment of end-stage heart failure (HF). Heart transplantation patients present lower exercise capacity due to cardiovascular and musculoskeletal alterations leading thus to poor quality of life and reduction in the ability of daily self-service. Impaired vascular function and diastolic dysfunction cause lower cardiac output while decreased skeletal muscle oxidative fibers, enzymes and capillarity cause arteriovenous oxygen difference, leading thus to decreased peak oxygen uptake in heart transplant recipients. Exercise training improves exercise capacity, cardiac and vascular endothelial function in heart transplant recipients. Pre-rehabilitation regular aerobic or combined exercise is beneficial for patients with end-stage HF awaiting heart transplantation in order to maintain a higher fitness level and reduce complications afterwards like intensive care unit acquired weakness or cardiac cachexia. All hospitalized patients after heart transplantation should be referred to early mobilization of skeletal muscles through kinesiotherapy of the upper and lower limbs and respiratory physiotherapy in order to prevent infections of the respiratory system prior to hospital discharge. Moreover, all heart transplant recipients after hospital discharge who have not already participated in an early cardiac rehabilitation program should be referred to a rehabilitation center by their health care provider. Although high intensity interval training seems to have more benefits than moderate intensity continuous training, especially in stable transplant patients, individualized training based on the abilities and needs of each patient still remains the most appropriate approach. Cardiac rehabilitation appears to be safe in heart transplant patients. However, long-term follow-up data is incomplete and, therefore, further high quality and adequately-powered studies are needed to demonstrate the long-term benefits of exercise training in this population.

show abstract

“…6 Small randomised controlled trials have shown that rehabilitation improves autonomic control (both cardiac and peripheral), 10 muscle strength and body composition, 11 while for endothelial function, synthesis of a small body of evidence shows high heterogeneity and the effect remains unclear. 12 Additionally, in a Cochrane systematic review and meta-analysis, ET was efficacious for increasing peak VO 2 . 13 However, considering the broader spectrum of exercise interventions, it is unknown whether any modality is superior in terms of efficacy or potential for harm.…”

Section: Introductionmentioning

confidence: 99%

Exercise training modalities for heart transplant recipients: a systematic review and network meta-analysis protocol

et al. 2020

View full text Add to dashboard Cite

IntroductionHeart transplantation is the gold standard treatment for selected patients with end-stage heart failure. Although this procedure can improve quality and prolong life expectancy, several of these patients persist with decreased exercise tolerance. Evidence suggests that exercise training can bring multifactorial benefits to heart transplant (HTx) recipients. However, it is unclear that exercise modality should be preferred. Therefore, the aim of this systematic review and network meta-analysis is to compare the efficacy and safety of different training modalities in HTx recipients.Methods and analysisWe will perform a comprehensive literature search in PubMed/MEDLINE, Embase, The Cochrane Library, CINAHL, Scopus, SportDISCUS, Web of Science Core Collection and PEDro from inception until November 2020. Two registries (ClinicalTrials.gov and REBEC) will also be searched for potential results in unpublished studies. There will be no restriction on language, date of publication, publication status or sample size. We will include randomised controlled trials enrolling adult HTx recipients with the presence of at least one exercise training group, which might be compared with another training modality and/or a non-exercise control group for a minimum of 4 weeks of intervention. The primary outcomes will be peak oxygen consumption and occurrence of adverse events. As secondary outcomes, the interaction between pulmonary ventilation, pulmonary perfusion and cardiac output, oxygen uptake efficiency slope, heart rate response, oxygen pulse, peak blood pressure and peak subjective perception of effort. In addition, we will evaluate the 6 min walking distance, health-related quality of life, endothelial function, muscle strength, body fat percentage and lean mass. Risk of bias will be assessed using the Cochrane RoB V.2.0 tool, and we plan to use the Confidence in Network Meta-Analysis tool to assess confidence in the results. All materials (raw data, processed data, statistical code and outputs) will be shared in a public repository.Ethics and disseminationGiven the nature of this study, no ethical approval will be required. We believe that the findings of this study may show which is the most efficacious and safe physical training modality for HTx recipients. The completed systematic review and network meta-analysis will be submitted to a peer-reviewed journal.PROSPERO registration numberCRD42020191192.

show abstract

Effect of exercise on endothelial function in heart transplant recipients: systematic review and meta-analysis

Cited by 6 publications

References 17 publications

A Review of High-Intensity Interval Training in Heart Transplant Recipients

A Review of High-Intensity Interval Training in Heart Transplant Recipients

Exercise training in heart transplantation

Exercise training modalities for heart transplant recipients: a systematic review and network meta-analysis protocol

Contact Info

Product

Resources

About