The purpose of this study was to conduct a pilot clinical trial to test the feasibility and efficacy of an exercise program and anti-depressant treatment compared with usual care in improving the emotional and physical functioning of older adults with minor depression. Participants were 37 older adults with minor depression who were randomized to exercise, sertraline, or usual care; 32 participants completed the 16 week study. Outcomes included measures of both emotional (clinician and selfreport) and physical (observed and self-report) functioning. There were trends for the superiority of the exercise and sertraline conditions over usual care in improving SF-36 mental health scores and clinician-rated depression scores. Individuals in the exercise condition showed greater improvements in physical functioning than individuals in the usual care condition. Both sertraline and exercise show promise as treatments for late-life minor depression. However, exercise has the added benefit of improving physical functioning as well.Minor depression, characterized by depressive symptoms which do not fulfill the severity requirement for major depression, is the most common type of depression experienced by older adults . In a recent Dutch community-based sample, Beekman and colleagues reported a 10% prevalence of minor depression compared with only a 2% prevalence of major depression in that sample. This is consistent with Tannock and Katona's findings (Tannock & Katona, 1995) that the incidence of minor depression increases with age. According to DSM-IV (American Psychiatric Association, 1994), minor depression is characterized by depressed mood or anhedonia and 1 to 3 of the following symptoms over a 2 week period: appetite disturbance, sleep disturbance, psychomotor agitation or retardation, loss of energy, feelings of worthlessness or guilt, difficulty concentrating, and recurrent thoughts of death.Minor depression is associated with a number of adverse health outcomes. It is a risk factor for major depression (Kessler et al., 1997) and is associated with increased numbers of chronic diseases (Beekman et al., 1997), functional limitations (Beekman et al., 1997), increased severity of medical illness (Barefoot & Schroll, 1996;Koenig, 1997), increased service utilization (Callahan et al., 1994;Cuijpers et al., 2004;Wagner et al., 2000), and increased risk of mortality (Barefoot & Schroll, 1996;Enzell, 1984;Murphy et al., 1987; 1999a). In addition to functional limitations, physical disability is also a consequence of both minor and major depression. The risk for onset of disability in persons with late-life depression is significantly higher than in older adults without depression, and is similar or even greater than the risk for disability associated with other chronic illnesses (Penninx et al., 1999b). Furthermore, number of depressive symptoms is associated with increasing impairment in activities of daily living (Langa et al., 2004). Among those older adults with 1-3 symptoms of depression, 30% reported diffi...