Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease

Hambrecht, Rainer; Wolf, Anamaria; Gielen, Stephan; Linke, Axel; Hofer, Jürgen; Erbs, Sandra; Schoene, Nina; Schuler, Gerhard

doi:10.1056/nejm200002173420702

Cited by 1,087 publications

(300 citation statements)

References 26 publications

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“…In CAD, the balance between NO production and NO inactivation is disrupted, thereby causing endothelial dysfunction 36, 57. In addition to reduced bioavailability of the NO precursor tetrahydrobiopterin, blunted eNOS expression and phosphorylation at the serine 1177 residue and eNOS inhibition by asymmetric dimethylarginine have been elucidated as the reasons for blunted coronary NO production in CAD 58.…”

Section: Vascular Alterations In Cadmentioning

confidence: 99%

“…The impact of exercise training on coronary endothelial functions of conduit and resistance vessels in patients with CAD was thoroughly investigated by Hambrecht and coworkers some years ago 57. Those patients were randomly assigned to 4 weeks of in‐hospital bicycle ergometer training or a control group that continued a sedentary lifestyle.…”

Section: Mechanism 1: Partial Correction Of Endothelial Dysfunctionmentioning

confidence: 99%

“…The fact that chest wall muscles were not directly trained in this study suggests that exercise training exerts circulation‐wide effects rather than only local adaptations in the blood vessels supplying trained muscles. Hambrecht's milestone studies on human endothelial function combining exercise training intervention, in vivo measurements, and molecular analysis stimulated a vast amount of work on the mechanism of improved endothelial function 32, 36, 57. The impact of exercise training on the multistep activation of eNOS on the one hand and reduced ROS production on the other hand was recently reviewed by Adams et al 81…”

Section: Mechanism 1: Partial Correction Of Endothelial Dysfunctionmentioning

confidence: 99%

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Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

Self Cite

159

120

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Section: Vascular Alterations In Cadmentioning

confidence: 99%

Section: Mechanism 1: Partial Correction Of Endothelial Dysfunctionmentioning

confidence: 99%

Section: Mechanism 1: Partial Correction Of Endothelial Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

Self Cite

159

120

View full text Add to dashboard Cite

“…Additionally, exercise was found to also improve the endothelium-dependent function in adults with cardiac failure [12,13] and coronary disease [14,15].…”

Section: Discussionmentioning

confidence: 99%

Effects of l-arginine supplementation on blood pressure reduction pre-, peri-, and post-cardiovascular stimulus in hypertensive subjects with different angiotensin-converting-enzyme genotypes

Malfatti¹,

Pavlak²,

Silva³

et al. 2018

Hum Mov.

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Purpose. The present study investigated whether L-arginine supplementation reduces blood pressure (BP) in hypertensive subjects with different ACE genotypes. Methods. Eight male hypertensive patients received L-arginine (2 or 4 g/day) or a placebo for a period of 4 days prior an exercise test. Statistical analysis consisted of one-way analysis of variance. Results. L-arginine supplementation induced a statistically significant (p < 0.05) reduction in systolic BP measured during rest (reductions of 7.8% and 12.3% with 2 and 4 g/day, respectively), exercise (reductions of 11.8% and 10.4% with 2 and 4 g/day, respectively), and recovery (reductions of 11.7% and 10.7% with 2 and 4 g/day, respectively). The observed magnitude of BP reduction suggests an association with ACE polymorphism; a larger effect was seen with the II and DI genotypes compared with the DD genotype (II: 121 mmHg and DI: 133 mmHg vs. DD: 144 mmHg). Conclusions. The results showed that L-arginine supplementation at low doses was efficient in reducing BP and that vasodilator actions that occurred through the secretion of nitric oxide might be ACE genotype dependent.

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“…Healthy compliant brachial arteries normally have a PWV of 7-9 ms -1 , whereas stiffer arteries tend to be in the range of 12-15 ms -1(2,3) . It has been hypothesised that regular physical activity improves endothelial function due to vascular shear stress causing an increased production of the vasodilator nitric oxide (NO) (4) . We previously reported that six months of brisk walking was associated with a decrease in PWV (5) .…”

mentioning

confidence: 99%

Are improvements in arterial stiffness associated with moderate physical activity and modulated by nitric oxide by-products in overweight adults?

et al. 2012

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Arterial stiffness, measured via pulse wave velocity (PWV) has been shown to be a strong independent predictor of cardiovascular morbidity and all-cause mortality (1) . Healthy compliant brachial arteries normally have a PWV of 7-9 ms -1 , whereas stiffer arteries tend to be in the range of 12-15 ms -1(2,3) . It has been hypothesised that regular physical activity improves endothelial function due to vascular shear stress causing an increased production of the vasodilator nitric oxide (NO) (4) . We previously reported that six months of brisk walking was associated with a decrease in PWV (5) . Here we investigated whether the observed beneficial changes in PWV following regular brisk walking were associated with changes in serum nitrate and nitrite (NO x ) (a surrogate marker for the vasodilator NO) concentrations.77 overweight sedentary individuals (19 males, 58 females; mean age 45.6 (SD 6.55) years; BMI 29.18 (SD 4.27) kg/m 2 ) participated in a randomised control trial and were allocated to one of three groups: control group (n25), walking with monthly telephone contact group (n25) and walking with weekly telephone contact group (n27). The walking groups were asked to incorporate 3 · 10 minute bouts of brisk walking into their daily routine on 5days/week and were contacted over six months on to provide support. The control group were given light stretching exercises to carry-out on 5days/week and were contacted on a monthly basis to control for attention effects. Percentage body fat (Tanita scales), BMI (kg/m 2 ), and PWV were measured at baseline and repeated after six months with follow-up measurements taken four months later. PWV was measured using a sensor based device as described by McLaughlin et al. (2) . For the purposes of the present investigation, both walking groups were combined (n52) and telephone contact was included as a covariate. Time by group interactions were analysed using repeated measures two-way analysis of covariance (ANCOVA). Between subject differences were analysed using a one-way ANOVA with posteriori Tukey Honestly Significant Difference (HSD) test.There was a significant decrease in PWV (P < 0.001) coupled with significant increases in NO x (P < 0.001) over the 6 month intervention, in the walking group as compared to control, and these beneficial effects were sustained beyond the end of the intervention period (i.e. at 4 months follow-up) (Figure 1 and 2). Furthermore a strong negative correlation between PWV and NO x was also observed (r = -0.65, P < 0.001).The results demonstrate that the beneficial changes in PWV observed with regular brisk walking for 3 · 10 minutes per day may be explained by concurrent increases in nitric oxide by-products in these overweight individuals.

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Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease

Abstract: Exercise training improves endothelium-dependent vasodilatation both in epicardial coronary vessels and in resistance vessels in patients with coronary artery disease.

Cited by 1,087 publications

References 26 publications

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Effects of l-arginine supplementation on blood pressure reduction pre-, peri-, and post-cardiovascular stimulus in hypertensive subjects with different angiotensin-converting-enzyme genotypes

Are improvements in arterial stiffness associated with moderate physical activity and modulated by nitric oxide by-products in overweight adults?

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