Effect of exercise intensity and duration on the levels of stress hormones and hypothalamic-pituitary–gonadal axis in adult male rats: an experimental study

Khajehnasiri, Nazli; Dehkordi, Mehdi Banitalebi; Amini-Khoei, Hossein; Mohammadabadi, Motahareh Sadat Mirhaj; Sadeghian, Reihaneh

doi:10.1007/s42000-021-00303-4

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…Exercise stimulates the hypothalamicpituitary-adrenal (HPA) axis because it is a stress response to the body [36]. Athletes' testosterone secretion may be suppressed as a result of the repressed release of gonadotropins and the direct and indirect effects of elevated corticotropin-releasing hormone (CRH), corticotropin, and cortisol [37]. Additionally, glucocorticoids reduce gonadal axis activity at the hypothalamic-pituitary level, and Leydig cells have been found to express CRH and its receptor, which inhibits T production [36].…”

Section: Histopathological and Immunohistochemical Resultsmentioning

confidence: 99%

“…According to previous researches, exercisehypogonadal male disease and reduced spermatogenic function are the results of long-term high-intensity exercise [2]. Several studies have hypothesized that high-intensity exercise-induced reproductive failure is related to the hypothalamicpituitary-gonadal regulatory axis, even if the precise physiological mechanism behind this association is unknown [3]. Additionally, the testis is one of the most susceptible organs to oxidative stress, which raises the formation of reactive oxygen species (ROS), during periods of high exercise.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Resveratrol against Testicular Dysfunction Induced by Forced Swimming Exercise in Adult Rats

Khalil

Abdelghany

Fatah

et al. 2022

Zagazig University Medical Journal

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Background:The effect of vigorous exercise on testicular function is poorly understood. This work aims to identify the resveratrol influence on the altered reproductive function induced by forced exercise and to screen the relevant possible mechanisms. Methods: The study comprised control, forced exercise (FE), and resveratrol treatment groups carried out on a total of 24 adult male rats. After 8 weeks of the exercise, the pituitary and testicular hormones, corticosterone, tumor necrosis factor (TNF-α), IL-6, epididymal sperm parameters, testicular oxidantantioxidant markers, testicular ornithine decarboxylase (ODC) activity, polyamines, testicular histopathology, and immunohistochemistry for apoptotic reactions were all measured. Results: The FE group showed significant reductions in the pituitary and testicular hormones, sperm count, and motility, while corticosterone, TNFα, IL-6 serum levels, and aberrant forms of sperms were significantly increased. Testicular tissue displayed abnormal architecture, apoptotic changes with a significantly increased malondialdehyde level, ODC activity and polyamines, and a reduction in superoxide dismutase activity. In comparison to the FE group, administration of resveratrol significantly improved the gonadal hormones, corticosterone, TNF-α, IL-6 levels, sperm parameters, oxidant-antioxidant system, ODC activity, and polyamines with an enhancement of testicular architecture and apoptosis. Conclusion: Resveratrol was effective in attenuating testicular dysfunction caused by forced swimming exercise in rats.

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Section: Histopathological and Immunohistochemical Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Resveratrol against Testicular Dysfunction Induced by Forced Swimming Exercise in Adult Rats

Khalil

Abdelghany

Fatah

et al. 2022

Zagazig University Medical Journal

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“…Several studies have reported that the HPA axis is activated in response to exercise. Long-term exercise is the most effective exercise which improves metabolic and cardiorespiratory function, and play a significant role in reducing stress and stress hormone levels by modulating HPA pathway activity (114,(123)(124)(125). In addition, moderate-intensity exercise has been shown to increase dopamine in the prefrontal cortex and reduce corticosterone secretion (114).…”

Section: Discussionmentioning

confidence: 99%

Effect of Running Training on Growth Factors and Astrogliosis and Cell Injury of the Hippocampus in Stressed Rats

Safari

Jahromi

Hadi

et al. 2023

Preprint

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The aim of this study was evaluating the effect of running training (RT) on brain-derived neurotrophic factor (BDNF) and its receptor TrKB, glial fibrillary acidic protein (GFAP), dark neurons and thickness of CA1 and dentate gyrus (DG), corticosterone and spatial memory performance in adult male rats exposed to chronic stress. Adult male wistar rats were randomly assigned to five groups: RT; exposure to chronic mild stress (CS); exposure to chronic mild stress followed by running training, (CS + RT), (CS + Recovery); control group. Findings indicated that the lowest expression of GFAP, number of dark neurons and corticosterone level, the highest thickness of CA1, DG, BDNF and TrKB and spatial memory performance were observed in the RT group. In the CS + RT group, expression of GFAP, the number of dark neurons and corticosterone level were lower, while thickness of CA1 and DG, BDNF, TrKB and spatial memory performance were higher compared to control and CS + Recovery. In the CS group, the expression of GFAP, the number of dark neurons and corticosterone level were highest and thickness of CA1 and DG, BDNF, TrKB and spatial memory performance were lowest among the study groups. In the CS + Recovery group, the expression of GFAP, the number of dark neurons and corticosterone level were lower, compared to the CS group. The study revealed that running training could attenuate the expression of GFAP, the number of dark neurons, corticosterone level and improve stress-induced reduction of BDNF, TrKB and spatial memory.

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“…Ultimately the comparative CT method was employed to evaluate the results of the quantitative real-time PCR (ΔΔCT Method). The arithmetic formula was used to measure the relative expression of the target mRNAs over the reference values [ 37 , 38 ].…”

Section: Methodsmentioning

confidence: 99%

Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

Roshani

Hatami²,

Sadeghian³

et al. 2022

Heliyon

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Effect of exercise intensity and duration on the levels of stress hormones and hypothalamic-pituitary–gonadal axis in adult male rats: an experimental study

Cited by 8 publications

References 33 publications

Protective Effect of Resveratrol against Testicular Dysfunction Induced by Forced Swimming Exercise in Adult Rats

Protective Effect of Resveratrol against Testicular Dysfunction Induced by Forced Swimming Exercise in Adult Rats

Effect of Running Training on Growth Factors and Astrogliosis and Cell Injury of the Hippocampus in Stressed Rats

Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

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