Effect of exercise augmentation of cognitive behavioural therapy for the treatment of suicidal ideation and depression

Abdollahi, Abbas; LeBouthillier, Daniel M.; Najafi, Mahmoud; Asmundson, Gordon J.G.; Hosseinian, Simin; Shahidi, Siamak; Carlbring, Per; Kalhori, Atefeh; Saad, Hassan; Jalili, Marzieh

doi:10.1016/j.jad.2017.05.012

Cited by 44 publications

(32 citation statements)

References 40 publications

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“…Behavioral therapy interventions included cognitive behavioral therapy (CBT), psychotherapy (Psy), stress management (SM), education (Edu), cognitive training, and a brief cognitive program classified as "other". The majority of studies employed CBT (n = 11) [29,31,34,36,38,[40][41][42][43][44][45]. Two studies used mixed behavioral therapies (CBT+Psy [34], SM+Edu [35]).…”

Section: Intervention Characteristicsmentioning

confidence: 99%

“…Two studies used mixed behavioral therapies (CBT+Psy [34], SM+Edu [35]). Nine studies employed aerobic exercise (AE) as the sole exercise type [22,[31][32][33]36,41,42,44,45], two studies used resistance exercise (RE) [39,43], six studies combined AE and RE [30,34,35,37,38,40], and one study employed yoga [29]. No studies were identified that implemented Tai Chi exercise.…”

Section: Intervention Characteristicsmentioning

confidence: 99%

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The Combined Effect of Exercise and Behavioral Therapy for Depression and Anxiety: Systematic Review and Meta-Analysis

Bourbeau

Moriarty

Ayanniyi

et al. 2020

Behavioral Sciences

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Behavioral therapy (BT) and exercise are efficacious treatments for depression and anxiety when employed separately. The combination of BT and exercise (BT+Ex) may augment improvements but the combined effect of these therapies is not fully elucidated. The purpose of this meta-analysis was to determine if BT+Ex yielded a significant reduction in depression and anxiety symptoms compared to BT alone (BT). Randomized controlled studies published prior to September 2019 were searched among several databases (PUBMED, MEDLINE, PsychArticle, and Cochrane Central Register of Clinical Trials). Studies that measured depression and anxiety symptoms following BT+Ex vs. BT were extracted and analyzed. The effect of these therapies on depression and anxiety were analyzed. Subgroup analyses were performed to evaluate the effect of exercise intensity (moderate and high), exercise type (aerobic and combined exercise), and baseline levels of depression. The moderating effects of gender, age, and treatment duration were performed. Data were extracted from 18 studies (1686 participants, mean age = 47 years, 65% female). There was a significant effect of BT+Ex on symptoms of depression. The effect of BT+Ex was significant for moderate intensity exercise and elevated baseline levels of depression. Age moderated the effect for depression. There was a significant effect of BT+Ex on depressive symptoms in humans. Exercise intensity and elevated depressive symptoms may play a role in the effect of exercise.

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Section: Intervention Characteristicsmentioning

confidence: 99%

Section: Intervention Characteristicsmentioning

confidence: 99%

The Combined Effect of Exercise and Behavioral Therapy for Depression and Anxiety: Systematic Review and Meta-Analysis

Bourbeau

Moriarty

Ayanniyi

et al. 2020

Behavioral Sciences

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“…One such treatment option is physical exercise. Exercise has been shown to be effective as monotherapy [10][11][12][13] and as augmentation strategy for antidepressant medication and psychological treatment [14][15][16][17][18][19]. Previous research showed that especially the combination of exercise and another treatment (i.e.…”

Section: Introductionmentioning

confidence: 99%

Exercise enhances: study protocol of a randomized controlled trial on aerobic exercise as depression treatment augmentation

et al. 2020

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Background Major depressive disorder (MDD) is a considerable public health concern. In spite of evidence-based treatments for MDD, many patients do not improve and relapse is common. Therefore, improving treatment outcomes is much needed and adjunct exercise treatment may have great potential. Exercise was shown to be effective as monotherapy for depression and as augmentation strategy, with evidence for increasing neuroplasticity. Data on the cost-effectiveness and the long-term effects of adjunct exercise treatment are missing. Similarly, the cognitive pathways toward remission are not well understood. Methods The present study is designed as a multicenter randomized superiority trial in two parallel groups with follow-up assessments up to 15 months. Currently depressed outpatients (N = 120) are randomized to guideline concordant Standard Care (gcSC) alone or gcSC with adjunct exercise treatment for 12 weeks. Randomization is stratified by gender and setting, using a four, six, and eight block design. Exercise treatment is offered in accordance with the NICE guidelines and empirical evidence, consisting of one supervised and two at-home exercise sessions per week at moderate intensity. We expect that gcSC with adjunct exercise treatment is more (cost-)effective in decreasing depressive symptoms compared to gcSC alone. Moreover, we will investigate the effect of adjunct exercise treatment on other health-related outcomes (i.e. functioning, fitness, physical activity, health-related quality of life, and motivation and energy). In addition, the mechanisms of change will be studied by exploring any change in rumination, self-esteem, and memory bias as possible mediators between exercise treatment and depression outcomes. Discussion The present trial aims to inform the scientific and clinical community about the (cost-)effectiveness and psychosocial mechanisms of change of adjunct exercise treatment when implemented in the mental health service setting. Results of the present study may improve treatment outcomes in MDD and facilitate implementation of prescriptive exercise treatment in outpatient settings. Trial registration This trial is registered within the Netherlands Trial Register (code: NL8432, date: 6th March, 2020).

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“…Furthermore, various anti-depressive treatments such as antidepressants, physical exercise as well as electro-convulsion significantly enhance neurogenesis (Hanson et al, 2011). Particularly, exercise which proves to be an effective and economical treatment for depression (Duman et al, 2008;Carek et al, 2011;Abdollahi et al, 2017;VanDerwerker et al, 2018) has also been known to enhance neurogenesis (Beauquis et al, 2010;Lee et al, 2016;Nishii et al, 2017;Leem et al, 2018;Yau et al, 2018), a process involves the generation of new neurons and neuronal connections in the sub-ventricular area of the lateral ventricle and the DG of the hippocampus (Curtis et al, 2012;Miller et al, 2013). In the present study, hippocampal cellular changes were examined by staining with three various markers BrdU, Ki67 and DCX.…”

Section: Discussionmentioning

confidence: 99%

Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice

Wang

Liang

Chen

et al. 2020

Front. Cell. Neurosci.

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Adiponectin, a cytokine secreted by mature adipocytes, proves to be neuroprotective. We have previously reported that running triggers adiponectin up-regulation which subsequently promotes generation of hippocampal neurons and thereby alleviates depression-like behaviors in non-stressed mice. However, under the stressing condition, whether adiponectin could still exert antidepressant-like effects following exercise remained unexplored. In this study, by means of repeated corticosterone injections to mimic stress insult and voluntary wheel running as physical exercise intervention, we examined whether exercise-elicited antidepressive effects might involve adiponectin's regulation on hippocampal neurogenesis and dendritic plasticity in stressed mice. Here we show that repeated injections of corticosterone inhibited hippocampal neurogenesis and impaired dendritic morphology of neurons in the dentate gyrus of both wild-type and adiponectin-knockout mice comparably, which subsequently evoked depression-like behaviors. Voluntary wheel running attenuated corticosterone-suppressed neurogenesis and enhanced dendritic plasticity in the hippocampus, ultimately reducing depressionlike behaviors in wild-type, but not adiponectin-knockout mice. We further demonstrate that such proneurogenic effects were potentially achieved through activation of the AMP-dependent kinase (AMPK) pathway. Our study provides the first evidence that adiponectin signaling is essential for physical exercise-triggered effects on stress-elicited depression by retaining the normal proliferation of neural progenitors and dendritic morphology of neurons in the hippocampal dentate gyrus, which may depend on activation of the AMPK pathway.

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Effect of exercise augmentation of cognitive behavioural therapy for the treatment of suicidal ideation and depression

Cited by 44 publications

References 40 publications

The Combined Effect of Exercise and Behavioral Therapy for Depression and Anxiety: Systematic Review and Meta-Analysis

The Combined Effect of Exercise and Behavioral Therapy for Depression and Anxiety: Systematic Review and Meta-Analysis

Exercise enhances: study protocol of a randomized controlled trial on aerobic exercise as depression treatment augmentation

Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice

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