Effect of Excipients on Pharmaceutical Parameters on Topical Gel Loaded With Povidone Iodine, Honey and Aloe Vera

Abstract

The aim of the study is to formulate and evaluate topical gels prepared with povidone iodine, honey and aloe vera using carbopol and poloxamer. Ninetopical gels were formulated using carbopol and poloxamerat various concentrations and evaluated for, rheological properties, in vitro drug release profile, release mechanism and in vitro antimicrobial activity, pH, spreadability, viscosity, flow index and flow behaviour for all the formulations and were found within acceptable range. The F8 has 99% of cumulative drug release percentage. The invitro mechanism release showed that F8 fits with first order kinetics (r 2 = 0.9967) followed by Higuchi model (r 2 = 0.9657) diffusion process based on Fick's Law. F8 formulation showed minimum inhibitory one of 34.46 mm and 27.57 mm for antibacterial and antifungal activity respectively, which exhibited more prominently than other formulations. Based on the findings, it was concluded that F8 has an effective antimicrobial activity and maximum drug release.