Effect of evodiamine and berberine on miR-429 as an oncogene in human colorectal cancer

Liu, Hong; Huang, Chao; Wu, Liyun; Wen, Bin

doi:10.2147/ott.s104729

Cited by 53 publications

(27 citation statements)

References 48 publications

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“…Colorectal cancer (CRC), which progresses from adenomas to adenocarcinomas, is a leading cause of cancer death worldwide [ 1 ]. It is widely accepted that this progression is triggered by the accumulation of both genetic and epigenetic factors [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet

Wang

Guan

et al. 2018

Molecules

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Background: Berberine (BBR) has been extensively reported to inhibit colorectal cancer (CRC) development, though its bioavailability is poor. Nowadays, an increasing number of studies have shown that BBR significantly accumulates in the intestines and could regulate gut microbiota in obesity. The purpose of this study was to further explore the effects of BBR on gut microbiota in Apc min/+ mice receiving a high fat diet (HFD). Methods: Apc min/+ mice received either HFD alone or HFD and BBR for 12 weeks. The intestinal tissues were collected to evaluate the efficiency of BBR on neoplasm development by hematoxylin and eosin staining. Meanwhile, immunohistochemistry was conducted to investigate the effects of BBR on cyclin D1 and β-catenin in colon tissues. Fecal samples were subjected to 16S rRNA sequencing. Results: BBR significantly reduced intestinal tumor development and altered the structure of gut microbiota in Apc min/+ mice fed with an HFD. At the phylum level, it was able to significantly inhibit the increase in Verrucomicrobia. At the genus level, it was able to suppress Akkermansia and elevate some short chain fat acid (SCFA)-producing bacteria. Conclusions: BBR significantly alleviated the development of CRC in Apc min/+ mice fed with HFD and restored the enteric microbiome community.

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Section: Introductionmentioning

confidence: 99%

The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet

Wang

Guan

et al. 2018

Molecules

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“…Moreover, Liu et al found that miR-429 was an oncogene regulated by evodiamine and berberine in human CRC. These studies indicated that miR-429 might play important roles during chemotherapy in CRC [ 28 ]. In our research, our novel results indicated that miR-429 was significantly correlated with 5-FU response in CRC patients, and exerted its important function in distinguishing the patients with a response to 5-FU treatment from the patients with no response.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of MiR-429 as a Predictive Biomarker in Colorectal Cancer Patients Receiving 5-Fluorouracil Treatment

Dong

Cai

2016

Med Sci Monit

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Background5-Fluorouracil (5-FU) based treatment is the standard therapy for metastatic colorectal cancer (CRC), but the development of chemoresistance is inevitable. Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in malignant transformation. Thus, it is imperative that we find new diagnostic and prognostic marker for chemotherapy in CRC.Material/MethodsFor clinical parameter analysis, 78 CRC tissues and adjacent normal tissues and 45 serum specimens from CRC patients were included in this study. For chemo-response analysis, 116 primary tissues were collected from the patients receiving first-line 5-FU treatment. Quantitative Real-Time PCR (qRT-PCR) was used to detect microRNAs expression.ResultsThe expression of miR-429 was significantly increased in both serum and primary tissues from CRC patients, and enhanced miR-429 level was associated with tumor size, lymph node metastasis, and TNM stage. The diagnostic and prognostic values were also confirmed in CRC by using primary tissues. For patients receiving 5-FU-based treatment, miR-429 levels were significantly lower in responding group. The proportions of patients that did not experience response to therapy were higher in primary tumors with high miR-429 expression levels as compared with primary tumors with low miR-429 expression levels. Finally, Kaplan-Meier survival analysis showed that miR-429 is an independent prognostic indicator for chemo-response to 5-FU therapy among CRC patients.ConclusionsHigh level of miR-429 expression was correlated with enhanced malignant potential and poor prognosis of CRC patients. Furthermore, miR-429 could affect the chemo-sensitivity of CRC patients to 5-FU therapy and was associated with poor response to 5-FU-based chemotherapy in patients with CRC.

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“…86 In colon cancer cells, BBR down-regulated miR-429 and inhibited E-cadherin expression. 87 Together, BBR inhibits cancer invasion and metastasis by regulating the expression of microRNAs or interacting with them. Although studies have shown that BBR inhibited cancer development by interacting with microRNAs, the interaction sites and mechanisms associated with these inhibitory effects need to be further explored.…”

Section: Bbr's Other Functions Effects Of Bbr On Micrornamentioning

confidence: 99%

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

Wang¹,

Liu²,

Du³

et al. 2020

CMAR

145

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Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential antiinflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.

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Effect of evodiamine and berberine on miR-429 as an oncogene in human colorectal cancer

Cited by 53 publications

References 48 publications

The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet

The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet

The Clinical Significance of MiR-429 as a Predictive Biomarker in Colorectal Cancer Patients Receiving 5-Fluorouracil Treatment

<p>The Anti-Cancer Mechanisms of Berberine: A Review</p>

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