Effect of eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver

Parasakthy, K.; Dakshinamoorthy, Deepalakshmi P.; Shanthi, S.; Devaraj, Halagowder; Devaraj, Niranjali

doi:10.1016/0006-2952(95)00083-c

Cited by 78 publications

(34 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is interesting to note that antioxidants prevented CCl 4 hepatotoxicity, by inhibiting lipid peroxidation and increasing antioxidant enzyme activities (Teselkin et al, 2000;Kumaravelu et al, 1995). Recent studies have reported that the inhibition of CYP2E1, which is involved in CCl 4 biotransformation, decreases CCl 4 hepatotoxicity.…”

Section: Introductionmentioning

confidence: 97%

Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats

Nogueira

Borges²,

Souza³

2008

J of Applied Toxicology

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 97%

Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats

Nogueira

Borges²,

Souza³

2008

J of Applied Toxicology

View full text Add to dashboard Cite

“…Although data are limited, it has been suggested that the hepatoprotective effects have an antioxidant mechanistic basis, and that CCl4 toxicity, particular hepatotoxicity, is due to the inhibition of lipid peroxidation (Teselkin et al, 2000), the suppression of SGOT and SGPT (Lin and Huang, 2000), and the augmentation of antioxidant enzymes (Kumaravelu et al, 1995). Several researches have reported that probiotics and their fermented products possess antioxidative activities and free radical scavenging properties in vitro and in vivo (Osman et al, 2007;Nurrochmad et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Lee¹,

Park²,

Kim³

et al. 2015

The Korean Journal of Microbiology

View full text Add to dashboard Cite

Probiotics are microbial food supplements or components of bacteria which have traditionally been added to dairy foods for extra health boost. Our aim was to evaluate the hepatoprotective effect of Bifidobacterium adolescentis SPM0212 as probiotics, which we previously found has potential anti-hepatitis B virus activity. The study was conducted using Wistar albino rats and probiotics were treated orally for 9 days consecutively and acute liver injury was induced by administration of carbon tetrachloride (CCl4) on the 7th and 8th days. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT), as well as by histopathological examination. B. adolescentis SPM0212 significantly prevented the elevation of SGOT and SGPT levels, and reduced the negative effect of CCl4 on body and organ weights. Histopathological study revealed the livers of the carbon tetrachloride treated rats showed almost complete loss of normal hepatocyte architecture, but that rats treated with B. adolescentis SPM0212 showed minimal damage and normal hepatocyte architecture. Our results suggest that B. adolescentis SPM0212 be considered useful probiotics for protecting the liver from xenobiotics and hepatitis B virus, and as well as useful as a functional food for maintaining human health.

show abstract

“…Different phytochemicals originating from fruits are being exploited as possible sources of therapeutic agents. Phytochemicals act against diseases by up-regulating gene expressions of the antioxidant enzymes (Aruoma, 1994;Kumaravelu et al, 1995;Verma et al, 2013). Fisetin (3,7,3′, belongs to the flavonoid group which are found in many plants, fruits and vegetables.…”

Section: Effects Of Plant Flavonoids In Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

Kar¹,

Biswas²,

Banerjee³

2016

Biomed Res Ther

View full text Add to dashboard Cite

Abstract-Introduction: Pulmonary Fibrosis can severely disrupt lung function. The cause of Idiopathic Pulmonary Fibrosis (IPF) is still unclear. The treatment currently available for IPF provides minimal benefits. Bleomycin is used in research to induce experimental pulmonary fibrosis in animals. Plant flavonoids such as fisetin and curcumin are known for their anti-inflammatory properties. The aim was to demonstrate the path of physiological changes in bleomycin induced IPF and to further evaluate the reversal and ameliorative potentials of some plant flavonoids and their nanocomposites. Bleomycin administration is known to damage the lung epithelial cells resulting in lower cell numbers. Methods: The Balb/c mice were used as models for bleo-induced IPF. Inflammation was measured by the generation of ROS, RONI, and histological assessment. Cell proliferation was measured by MTS assay and CFU assay. Results: Our colony-forming assay in BALF also demonstrated a reduction (1.65 fold) in colony-forming unit after bleomycin administration. The number of colonies increased upon treatment with fisetin(1.20 fold) and curcumin (1.13 fold) respectively. MTT proliferation assay demonstrated a significant increase in the number of viable cells upon treatment with curcumin (1.42 fold) and fisetin (1.74 fold) respectively, in the lung. The NBT assay demonstrated a significant effect of curcumin in BALF, lung and peripheral blood. A significant effect of fisetin was observed in BALF and peripheral blood. Conclusion: These findings were also supported by the histological analyses of the lung samples. Curcumin showed highest potential for the treatment of IPF and fisetin showed its ameliorative effect.

show abstract

Effect of eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver

Cited by 78 publications

References 35 publications

Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats

Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

Contact Info

Product

Resources

About