Effect of Eucalyptus Oil Inhalation on Pain and Inflammatory Responses after Total Knee Replacement: A Randomized Clinical Trial

Jun, Yang; Kang, Purum; Min, Sun Seek; Lee, Jeong Min; Kim, Hyo Keun; Seol, Geun Hee

doi:10.1155/2013/502727

Cited by 41 publications

(30 citation statements)

References 23 publications

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“…Although analgesic medications are effective in reducing pain and nausea, uncomfortable side effects can prolong the healing process and increase hospitalization time [20]. In a randomized control study to examine pain management after total knee replacement surgery, patients treated with eucalyptus aromatherapy experienced significantly lower pain and blood pressure than the control group [21]. A study that examined lavender aromatherapy in patients recovering from breast biopsy surgery found that the aromatherapy group reported a significantly higher satisfaction with pain management than the control group, even though rates of pain, narcotic use, and discharge time were the same [20].…”

Section: Resultsmentioning

confidence: 99%

The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis

Lakhan

Sheafer

Tepper

2016

Pain Research and Treatment

137

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Background. Aromatherapy refers to the medicinal or therapeutic use of essential oils absorbed through the skin or olfactory system. Recent literature has examined the effectiveness of aromatherapy in treating pain. Methods. 12 studies examining the use of aromatherapy for pain management were identified through an electronic database search. A meta-analysis was performed to determine the effects of aromatherapy on pain. Results. There is a significant positive effect of aromatherapy (compared to placebo or treatments as usual controls) in reducing pain reported on a visual analog scale (SMD = −1.18, 95% CI: −1.33, −1.03; p < 0.0001). Secondary analyses found that aromatherapy is more consistent for treating nociceptive (SMD = −1.57, 95% CI: −1.76, −1.39, p < 0.0001) and acute pain (SMD = −1.58, 95% CI: −1.75, −1.40, p < 0.0001) than inflammatory (SMD = −0.53, 95% CI: −0.77, −0.29, p < 0.0001) and chronic pain (SMD = −0.22, 95% CI: −0.49, 0.05, p = 0.001), respectively. Based on the available research, aromatherapy is most effective in treating postoperative pain (SMD = −1.79, 95% CI: −2.08, −1.51, p < 0.0001) and obstetrical and gynecological pain (SMD = −1.14, 95% CI: −2.10, −0.19, p < 0.0001). Conclusion. The findings of this study indicate that aromatherapy can successfully treat pain when combined with conventional treatments.

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Section: Resultsmentioning

confidence: 99%

The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis

Lakhan

Sheafer

Tepper

2016

Pain Research and Treatment

137

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“…Based on the results of a previous trial (Moss et al, ), the level of significance and power were set at .05 and 0.95, respectively. The effect size of 0.80, which was large according to Cohen's formula (Sullivan & Feinn, ), was based on systolic BP, one of the primary indicators in this study (Jun et al, ). The number of subjects was calculated using the G‐power program version 3.1, with the minimum number of subjects required for each group was 35.…”

Section: Methodsmentioning

confidence: 99%

Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial

Shin¹,

Hsieh²,

Han³

et al. 2019

Phytotherapy Research

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Codonopsis lanceolata (CL) extract was shown to have antihypertensive effects in hypertensive rats. This randomized controlled trial was designed to investigate the ability of CL extract to prevent hypertension (HTN) in prehypertensive subjects.Eighty subjects aged 19-60 years with a systolic blood pressure (BP) of 120-139 mmHg and a diastolic BP of 80-89 mmHg were recruited over 3 months. Subjects were randomized 1:1 to a CL group and a placebo (PL) group and administered CL extract and starch, respectively, for 6 weeks. (BP) was measured and blood sampled at baseline and at the end of the trial. Relative to baseline, systolic BP was significantly decreased, and catalase activity was significantly increased following CL treatment in both the elevated systolic BP and stage 1 HTN subgroups. In the elevated systolic BP subgroup, serum nitrite concentration relative to baseline was significantly increased in CL compared to PL treated subjects (p = .038). In subjects with stage 1 HTN, high sensitivity C-reactive protein (p = .020) and malondialdehyde (p = .039) showed significantly greater reductions from baseline in the CL than in the PL group. In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.

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“…The data revealed that different neurochemical pathways were responsible for their action on cognition and subjective state. Jun et al [148] reported that the inhalation of eucalyptus oil effectively decreased patient’s pain and blood pressure after total knee replacement surgery.…”

Section: Effect Of Inhalation Of Fragrance On Psychophysiological mentioning

confidence: 99%

Influence of Fragrances on Human Psychophysiological Activity: With Special Reference to Human Electroencephalographic Response

2016

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The influence of fragrances such as perfumes and room fresheners on the psychophysiological activities of humans has been known for a long time, and its significance is gradually increasing in the medicinal and cosmetic industries. A fragrance consists of volatile chemicals with a molecular weight of less than 300 Da that humans perceive through the olfactory system. In humans, about 300 active olfactory receptor genes are devoted to detecting thousands of different fragrance molecules through a large family of olfactory receptors of a diverse protein sequence. The sense of smell plays an important role in the physiological effects of mood, stress, and working capacity. Electrophysiological studies have revealed that various fragrances affected spontaneous brain activities and cognitive functions, which are measured by an electroencephalograph (EEG). The EEG is a good temporal measure of responses in the central nervous system and it provides information about the physiological state of the brain both in health and disease. The EEG power spectrum is classified into different frequency bands such as delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), beta (13–30 Hz) and gamma (30–50 Hz), and each band is correlated with different features of brain states. A quantitative EEG uses computer software to provide the topographic mapping of the brain activity in frontal, temporal, parietal and occipital brain regions. It is well known that decreases of alpha and beta activities and increases of delta and theta activities are associated with brain pathology and general cognitive decline. In the last few decades, many scientific studies were conducted to investigate the effect of inhalation of aroma on human brain functions. The studies have suggested a significant role for olfactory stimulation in the alteration of cognition, mood, and social behavior. This review aims to evaluate the available literature regarding the influence of fragrances on the psychophysiological activities of humans with special reference to EEG changes.

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Effect of Eucalyptus Oil Inhalation on Pain and Inflammatory Responses after Total Knee Replacement: A Randomized Clinical Trial

Cited by 41 publications

References 23 publications

The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis

The Effectiveness of Aromatherapy in Reducing Pain: A Systematic Review and Meta-Analysis

Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial

Influence of Fragrances on Human Psychophysiological Activity: With Special Reference to Human Electroencephalographic Response

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