Effect of Etoposide Treatment on ERG Transfected H358 Cell Line

Abstract

Lung cancer is listed as the most fatal type of cancer around the world. ERG, a transcription factor, is an ETS family member protein. It is involved in Epithelial Mesenchymal Transition (EMT), metastasis and DNA repair defects. Etoposide is a chemotherapeutic agent used in treatment of a variety of different cancer types, including lung cancer. Moreover, Etoposide has been tested alone and in combination with other drugs in order to inhibit DNA synthesis and exhibit antitumor activity. The purpose of this study is to examine the effect of Etoposide treatment on ERG transfected non-small cell lung cancer (NSCLC) cell line, H358.