Effect of Ethanolic Extract of <i>Juglans regia</i> L. on Blood Sugar in Diabetes-Induced Rats

Asgary, Sedigheh; Parkhideh, Sahar; Solhpour, Ali; Hossein, Moulavi; Mahzouni, Parvin; Rahimi, Parisa

doi:10.1089/jmf.2007.0611

Cited by 69 publications

(40 citation statements)

References 24 publications

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“…Walnut leaf has been widely used in traditional medicine for the treatment of skin infl ammations and ulcers and for its antidiarrheic, antihelmintic, antiseptic and astringent properties (Almeida et al, 2008). Anti-infl ammatory, antinociceptive and antidiabetic activities of walnut leaves (Erdemoglu et al, 2003;Asgary et al, 2008), antioxidant effects of its seeds and radical scavenging of leaves have been previously reported (Almeida et al, 2008, Fukuda et al, 2003. However, there is no scientifi c report on biological activity of J. regia fl ower.…”

Section: Introductionmentioning

confidence: 99%

Biological activities of Juglans regia flowers

Nabavi¹,

Ebrahimzadeh²,

Nabavi³

et al. 2011

Rev. bras. farmacogn.

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Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, when compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 μg mL -1 . Extract showed good Fe 2+ chelating ability (IC50 43±1.5 μg mL -1 ). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and flavonoids in the extract.

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Section: Introductionmentioning

confidence: 99%

Biological activities of Juglans regia flowers

Nabavi¹,

Ebrahimzadeh²,

Nabavi³

et al. 2011

Rev. bras. farmacogn.

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“…Na literatura, trabalhos reportam a efetividade das plantas medicinais, sendo consideradas como perspectivas para obtenção de novas drogas para melhora do diabetes mellitus (Hasani-Ranjbar et al, 2008). Vários autores demonstraram efeitos benéficos das plantas medicinais para o diabetes, principalmente devido ao efeito hipoglicemiante (Asgary et al, 2008;de Ventera et al, 2008;Honório-França et al, 2008;Gbolade, 2009).…”

Section: Parâmetros Avaliados Grupo Controle (N=10) Grupo Diabético (unclassified

Efeito do composto "mais vida" na ativação de macrófagos de ratos diabéticos

França¹,

Fagundes²,

Leão³

et al. 2012

Rev. bras. plantas med.

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RESUMO:O objetivo deste trabalho foi avaliar a atividade funcional de macrófagos de ratos diabéticos, através da liberação do ânion superóxido, na presença do composto "mais vida". Os animais foram divididos em dois grupos, controle (N=20) e diabético (N=20). Avaliou-se a glicemia, massa corpórea e a liberação de superóxido pelos macrófagos de baço de ratos. O composto "mais vida" foi obtido através da mistura de extratos de sete plantas, sendo Orbignia martiana Rodr., Tabebuia avellanedae L.G., Arctium lappa L., Rosa centifolia L., Maytenus ilicifolia Mart., Vernonia condensata Baker e Thuja occidentalis L. Observou-se que glicemia foi maior no grupo diabético. A liberação espontânea do ânion superóxido pelos macrófagos foi menor no grupo diabético. O composto "mais vida", independente dos níveis glicêmicos, aumentou a liberação de superóxido dos macrófagos. Quando as células foram estimuladas pelos extratos vegetais isolados, também houve aumento na liberação do ânion superóxido pelos macrófagos em ambos os grupos. As maiores liberações de superóxido ocorreram quando os macrófagos foram estimulados pela Thuja occidentalis L., Rosa centifolia L., Tabebuia avellanedae L.G. e Maytenus ilicifolia Mart. Estes dados sugerem que a ativação de macrófagos pelo composto "mais vida" pode representar um mecanismo alternativo de defesa para infecções em indivíduos diabéticos.Palavras-chave: Fitoterápico, fagócitos, diabetes, aloxana, ânion superóxido ABSTRACT: Effects of "mais vida", a commercial natural mix, on the activation of macrophages from diabetic rats. This study investigated the effects of "mais vida", a commercial natural mix, on macrophages functional activity as evaluated by the superoxide release in diabetic rats. The animals were divided into two groups, control (N = 20) and diabetic (N = 20). This was achieved by determining blood glucose weight and the superoxide released by spleen macrophages. The "mais vida" mix was obtained by the combination of extracts from seven medicinal species, which were: Orbignia martiana Rodr., Tabebuia avellanedae L.G., Arctium lappa L., Rosa centifolia L., Maytenus ilicifolia Mart., Vernonia condensata Baker and Thuja occidentalis L. Blood glucose levels were significantly higher (p<0.05) in the diabetic group, as compared to blood glucose levels in the control group. Superoxide levels in macrophages isolated from normoglycemic rats were higher than those obtained from diabetic animals. The "mais vida" mix, independently of glycemic status, increased significantly the superoxide release in the macrophages. Each extract by itself also increased the superoxide release by phagocytes in the macrophages in both groups. The largest superoxide release occurred when the phagocytes were stimulated by Thuja occidentalis L., Rosa centifolia L., Tabebuia avellanedae L.G. and Maytenus ilicifolia Mart. In addition, the activation of macrophages by the "mais vida" mix may represent an additional protection mechanism for diabetic individuals against infections.

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“…All parts of the plant; stem, bark, leaves, fruits, seeds, seed oil are used in folk medicines to treat variety of health disorders including cancer [8]. Walnut has been widely used as herbal medicine in the treatment of diabetes [9] and in folk medicine to treat prostate and vascular disturbance [10]. Antiradicalar and antibacterial activities have also described for different J. regia cultivars [11].…”

Section: Introductionmentioning

confidence: 99%

Study of antioxidant potential in leaves, stems, nuts of Juglans regia L.

Raja¹,

Shaker²,

Sailaja³

et al. 2012

IJB

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Natural antioxidants can protect the human body from free radicals and retard the progress of many chronic diseases as well as lipid oxidative rancidity in foods. The role of antioxidants has protected effect against free radical damage that may cause many diseases including cancer. Primary sources of naturally occurring antioxidants are known as whole grains, fruits, and vegetables. Several studies suggest that regular consumption of nuts, mostly walnuts, may have beneficial effects against oxidative stress mediated diseases such as cardiovascular disease and cancer. The role of antioxidants has attracted much interest with respect to their protective effect against free radical damage that may cause many diseases including cancer. Juglans regia L. (walnut) contains antioxidant compounds, which are thought to contribute to their biological properties. Polyphenols, flavonoids and flavonols concentrations and antioxidant activity of Leaves, Stems and Nuts extract of Juglans regia L. as evaluated using DPPH, ABTS, Nitric acid, hydroxyl and superoxide radical scavenging activity, lipid peroxidation and total oxidation activity were determined. The antioxidant activities of Leaves, Stems and Nuts extract of Juglans regia L. were concentration dependent in different experimental models and it was observed that free radicals were scavenged by the test compounds in all the models.

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Effect of Ethanolic Extract of Juglans regia L. on Blood Sugar in Diabetes-Induced Rats

Cited by 69 publications

References 24 publications

Biological activities of Juglans regia flowers

Biological activities of Juglans regia flowers

Efeito do composto "mais vida" na ativação de macrófagos de ratos diabéticos

Study of antioxidant potential in leaves, stems, nuts of Juglans regia L.

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