Effect of ethanol/trisodium citrate lock on the mechanical properties of carbothane hemodialysis catheters

Use of Ethanol Lock Therapy to Reduce the Incidence of Catheter‐Related Bloodstream Infections in Home Parenteral Nutrition Patients

“…15 In addition, physical properties of hemodialysis catheters were not affected by exposure to 30% ethanol and 4% trisodium citrate locks for 9 weeks. 16 Case reports of frequently infected HPN patients have shown that ELT decreases the frequency of bloodstream infections. 13,17,18 A study of 28 infected children with cancer demonstrated ELT as a treatment modality.…”

Sellado con antibióticos o antisépticos en pacientes pediátricos con nutrición parenteral domiciliaria. Puesta al dí

“…Sin embargo, en el caso de los catéteres de poliuretano, la cosa no está tan clara. Existe un estudio en el que no se encontraron efectos significativos sobre la integridad de este tipo de catéteres de la exposición de etanol 70% durante un periodo de 9 semanas (24); sin embargo, hay otros 2 estudios que plantean dudas sobre su seguridad (27,28). De hecho, la mayoría de expertos y fabricantes recomiendan evitar el uso de etanol en catéteres de poliuretano (9,29).…”

Pros and cons of catheter lock solutions

“…In-vitro studies have shown that 70% ethanol successfully eradicates both planktonic and sessile microorganisms most commonly associated with CRB [44]. In-vitro research has shown minimal structural degradation with silicone catheters [47] and initial concerns on the effect of ethanol locks on polyurethane catheters [48] have since been mitigated [49]. The patients who received ethanol catheter locking had a significantly lower incidence of CRB (0.60 vs. 3.11 per 1000 catheter days) [45].…”