Effect of Ethanol on Polyunsaturated Fatty Acid Biosynthesis in Hepatocytes From Spontaneously Hypertensive Rats

Narce, Michel; Poisson, Jean‐Pierre; Bellenger, Jérôme; Bellenger, Sandrine

doi:10.1111/j.1530-0277.2001.tb02340.x

Cited by 16 publications

(6 citation statements)

References 27 publications

(17 reference statements)

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“…Studies that did not demonstrate the type of alcohol consumed showed conflicting results between papers ( 11 , 58 , 61 , 63 , 77 , 80 ) ; the majority of these showed negative associations with alcohol intake ( 58 , 61 , 76 , 80 ) . Mechanisms for the negative associations between alcohol intake and n -3 LCPUFA are still not fully understood in humans; however, animal and in vitro studies propose lipid peroxidation and changes in desaturase activities ( 103 – 105 ) . Different findings observed between the studies might be due to the differences in amounts of alcohol consumed, the regularity with which alcohol is consumed and whether participants consumed more quantity of alcohol for prolonged periods ( 106 ) .…”

Section: Discussionmentioning

confidence: 99%

Non-dietary factors associated with n-3 long-chain PUFA levels in humans – a systematic literature review

2019

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Numerous health benefits are attributed to the n-3 long-chain PUFA (n-3 LCPUFA); EPA and DHA. A systematic literature review was conducted to investigate factors, other than diet, that are associated with the n-3 LCPUFA levels. The inclusion criteria were papers written in English, carried out in adult non-pregnant humans, n-3 LCPUFA measured in blood or tissue, data from cross-sectional studies, or baseline data from intervention studies. The search revealed 5076 unique articles of which seventy were included in the qualitative synthesis. Three main groups of factors potentially associated with n-3 LCPUFA levels were identified: (1) unmodifiable factors (sex, genetics, age), (2) modifiable factors (body size, physical activity, alcohol, smoking) and (3) bioavailability factors (chemically bound form of supplements, krill oil v. fish oil, and conversion of plant-derived α-linolenic acid (ALA) to n-3 LCPUFA). Results showed that factors positively associated with n-3 LCPUFA levels were age, female sex (women younger than 50 years), wine consumption and the TAG form. Factors negatively associated with n-3 LCPUFA levels were genetics, BMI (if erythrocyte EPA and DHA levels are <5·6 %) and smoking. The evidence for girth, physical activity and krill oil v. fish oil associated with n-3 LCPUFA levels is inconclusive. There is also evidence that higher ALA consumption leads to increased levels of EPA but not DHA. In conclusion, sex, age, BMI, alcohol consumption, smoking and the form of n-3 LCPUFA are all factors that need to be taken into account in n-3 LCPUFA research.

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Section: Discussionmentioning

confidence: 99%

Non-dietary factors associated with n-3 long-chain PUFA levels in humans – a systematic literature review

2019

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“…Possible explanations include preferential uptake of PUFAs into the liver, increased synthesis of PUFAs by the liver, or their decreased metabolism. The notion that alcohol increases hepatic desaturase activity has been reported (Narce et al., ; Pawlosky et al., ), but the molecular mechanisms for this have not been elucidated.…”

Section: Discussionmentioning

confidence: 99%

Dietary Macronutrient Composition Determines the Contribution of DGAT1 to Alcoholic Steatosis

Huang

Yuen

Trites

et al. 2018

Alcoholism Clin & Exp Res

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“…Experimentally, hepatocytes exposed to high ethanol concentrations over a prolonged period showed reductions in desaturase activity (Narce et al, 2001). Given all AUD subjects in this study had liver cirrhosis, the decrease in chain length and unsaturation in fatty acids esterified to phosphatidylcholine or phosphatidylethanolamine here probably results largely from decreased synthesis of longer chain n‐3 fatty acids in the liver (Fernando et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Lipidome changes in alcohol‐related brain damage

Smith

Sheedy

McEwen

et al. 2021

Journal of Neurochemistry

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Alcohol‐related brain injury is characterized by cognitive deficits and brain atrophy with the prefrontal cortex particularly susceptible. White matter in the human brain is lipid rich and a major target of damage from chronic alcohol abuse; yet, there is sparse information on how these lipids are affected. Here, we used untargeted lipidomics as a discovery tool to describe these changes in the prefrontal, middle temporal, and visual cortices of human subjects with alcohol use disorder and controls. Significant changes to the lipidome, predominantly in the prefrontal and visual cortices, and differences between the white and grey matter of each brain region were identified. These effects include broad decreases to phospholipids and ceramide, decreased polyunsaturated fatty acids, decreased sphingadiene backbones, and selective decreases in cholesteryl ester fatty acid chains. Our findings show that chronic alcohol abuse results in selective changes to the neurolipidome, which likely reflects both the directs effects on the brain and concurrent effects on the liver.

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Effect of Ethanol on Polyunsaturated Fatty Acid Biosynthesis in Hepatocytes From Spontaneously Hypertensive Rats

Cited by 16 publications

References 27 publications

Non-dietary factors associated with n-3 long-chain PUFA levels in humans – a systematic literature review

Non-dietary factors associated with n-3 long-chain PUFA levels in humans – a systematic literature review

Dietary Macronutrient Composition Determines the Contribution of DGAT1 to Alcoholic Steatosis

Lipidome changes in alcohol‐related brain damage

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