Effect of Ethanol on Intestinal Absorption of Theophylline

Effect of Various Alcohols on Intestinal Net Water Flux and Theophylline Absorption in Rats

“…They were anesthetized with urethan, 1.5 g/kg ip. Net water flux from the intestine and theophylline absorption wew determined as previously described (1). Briefly, a portion of small intestine was cannulated in situ and 7 ml of an alcohol solution was introduced into the intestinal lumen ethylene glycol 4005 dissolved in SQrensen's phosphate buffer solution, pH 6.4.…”

“…Keyphrases Intestinal net water flux-effect of various alcohols, glycerin and propylene glycol effect on theophylline absorption in the rat 0 Theophylline absorption-effect of glycerin and propylene glycol, rats, related to effect of various alcohols on intestinal net water flux 0 Alcohols-effect on intestinal net water flux and theophylline absorption in rats Koysooko and Levy (1) recently showed that the rate of intestinal absorption of theophylline in rats is increased significantly by ethanol in low concentrations and that there is a positive rank-order correlation between the theophylline absorption rate and the net water flux from the intestine. These observations led to three important questions: Can other alcohols also enhance theophylline absorption?…”