Effect of Ethanol and pH on the Adsorption of Acetaminophen (Paracetamol) to High Surface Activated Charcoal, In Vitro Studies

Hoegberg, Lotte Christine Groth; Angelo, Helle R.; Christophersen, A B; Christensen, Hanne

doi:10.1081/clt-120002886

Cited by 28 publications

(37 citation statements)

References 29 publications

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“…Several in vitro studies investigate the adsorption capacity of different test substances to AC [9][10][11][13][14][15][16][17]. In this study, it is found that pH had no effect on the adsorption capacity.…”

Section: Discussionmentioning

confidence: 78%

“…These three formulations contain AC with same surface area 1600 m 2 /g. The previous studies [9][10][11][12] have shown that there is a difference in adsorption capacity with different formulations of AC. Also, only the unionized form of drug is adsorbed.…”

Section: Introductionmentioning

confidence: 99%

“…So this study was performed at two different pHs (simulated gastric pH: 3.4 and simulated intestinal pH: 7.2) and the effect of pH on adsorption of paracetamol to AC was studied. Most of the previous in vitro studies [9][10][13][14][15][16] used the drugs in pure form. In this study the paracetamol was derived from tablets to simulate in vivo intoxication.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Adsorption Studies of Paracetamol to Activated Charcoal Capsule, Powder and Suspension

Panthee¹,

Lohani²

2008

TOTOXIJ

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Abstract:Introduction: Adsorption capacity of activated charcoal to paracetamol was determined at simulated gastric environment, pH 3.4 and simulated intestinal environment pH 7.2. Three formulations of activated charcoal; powder, capsule and suspension were tested. Paracetamol was derived from tablet to simulate in vivo intoxication conditions.Methods: Activated charcoal and paracetamol were mixed at both the pHs. The amount of activated charcoal was varied to obtain activated charcoal-paracetamol ratio from 10:1 to 1:1. Then the mixtures were shaken, filtered and the content of remaining paracetamol was determined by UV spectrophotometer. 4 and 263.64 [229.13; 298.15] at pH 7.2 for suspension. The effect of pH on adsorption capacity was not significant. ResultsDiscussion: Under simulated conditions, the three formulations of activated charcoal adsorbed sufficient amount of paracetamol. The data show that activated charcoal 1g/kg body weight is sufficient a poisoned patient from if given shortly after intoxication.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Vitro Adsorption Studies of Paracetamol to Activated Charcoal Capsule, Powder and Suspension

Panthee¹,

Lohani²

2008

TOTOXIJ

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“…Large reductions in drug absorption occur when activated charcoal is administered soon after drug ingestion [2]. Some workers evaluated the adsorption of fluoroquinolones on some pharmaceutical adsorbents; it was observed that activated charcoal had a superior adsorption capacity to bentonite and kaolin [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of adsorption capacity of acetaminophen on activated charcoal dosage forms available in Nigeria by <i>in vitro</i> adsorption studies and scanning electron microscopy

Ilomuanya¹,

Ohere²,

Zubair³

et al. 2017

Trop. J. Pharm Res

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“…MC exhibits good adsorption potential to AA, and is possibly useful for detoxi-cation induced by AA overdose. [20][21][22] Thus, in the present study, AA was chosen as a model adsorption drug to MC.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Medicinal Carbon Granules by Wet Granulation Method Using Carboxymethylcellulose Sodium as a Binding Agent

Miyachi¹,

Onishi

2013

Jpn. J. Pharm. Health Care Sci.

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Medicinal carbon (MC) granules were prepared by the wet granulation method (wet mass extrusion) using carboxymethylcellulose sodium (CMC-Na) as a binding agent. In addition, croscarmellose sodium (CC-Na) was used as an additive at 0 -10％ (w/w) to MC. The obtained granules were examined in vitro for the physical strength, disintegration properties and adsorption characteristics. From friability tests, all the granules had good strength. They slightly disintegrated in the disintegration test with water for 30 min, but the addition of CC-Na significantly reduced the granule weight after the disintegration test. It was suggested that the addition of CC-Na should facilitate water immersion and consequently cause components such as CMC-Na or CC-Na to be lost partially; though such changes in the physical state could not be discernible to the naked eye. In adsorption experiments using acetaminophen solution (0.6 mg/mL), the adsorption capacity was almost retained in all the granules. Although the adsorption rate of the granules without CC-Na was fairly slower than that of MC powder, it was significantly improved by the addition of the CC-Na at 4 and 10％ (w/w). In particular, the granules with CC-Na at 10％ (w/w) displayed 65％ (w/w) of saturated adsorption with a small coefficient of variance (<7％) at 20 min after the start of the adsorption test. Thus, since the MC granules with CC-Na at 10％ displayed good physical strength, high adsorption capacity and a fairly fast adsorption rate, they are suggested to be useful as a compact MC dosage form.

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Effect of Ethanol and pH on the Adsorption of Acetaminophen (Paracetamol) to High Surface Activated Charcoal, In Vitro Studies

Cited by 28 publications

References 29 publications

In Vitro Adsorption Studies of Paracetamol to Activated Charcoal Capsule, Powder and Suspension

In Vitro Adsorption Studies of Paracetamol to Activated Charcoal Capsule, Powder and Suspension

Evaluation of adsorption capacity of acetaminophen on activated charcoal dosage forms available in Nigeria by <i>in vitro</i> adsorption studies and scanning electron microscopy

In Vitro Evaluation of Medicinal Carbon Granules by Wet Granulation Method Using Carboxymethylcellulose Sodium as a Binding Agent

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