Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) administration on duodenal calcium transport

Krawitt, Edward L.; Sampson, H. Wayne; Kunin, Arthur S.; Matthews, James L.

doi:10.1007/bf02059040

Cited by 18 publications

(4 citation statements)

References 31 publications

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“…A rise in serum phosphorus in patients treated with diphosphonates has also been observed by others (Fleisch and Bonjour, 1973; Procter and Gamble Co., personal communication) who have found that in adults this is not associated with a change in serum calcium. The lowering of serum calcium in children, which we have observed, is in contra-distinction to the hypercalcaemia induced in rats given a higher dosage (Bonjour et a/., 1972;Krawitt et a/., 1974) where the effect is attributed to decreased bone accretion rate with a secondary fall in calcium absorption from the gut (Bonjour et al, 1972). Calcium absorption in 2 of our patients showed a slight fall from pre-treatment values despite the absence of hyercalcaemia.…”

Section: Discussionsupporting

confidence: 43%

Diphosphonate Therapy in Nephrocalcinosis

McCredie¹,

Powell²,

Rotenberg³

1976

British Journal of Urology

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4 patients with nephrocalcinosis were treated with disodium ethane 1-hydroxy-1, 1-diphosphonate (EHDP) for a period of 13 months. No clinical side-effects were observed and growth proceeded normally. Radiographic changes of osteitis fibrosa cystica developed in 1 child and bone biopsy in 2 children showed defective osteoid mineralisation. It is suggested that EHDP prevented further crystal deposition in 3 children but did not prevent non-calcium stone formation in the 4th child. In view of this and the development of histological and radiographic evidence of osteomalacia and/or secondary hyperparathyroidism in these patients the value of EHDP remains dubious. On the other hand its use may be justified when rapidly increasing calcification is expected, as for example in hyperoxaluria.

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Section: Discussionsupporting

confidence: 43%

Diphosphonate Therapy in Nephrocalcinosis

McCredie¹,

Powell²,

Rotenberg³

1976

British Journal of Urology

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“…More recent studies have shown that administration of high levels of EHDP can result in a number of alterations in calcium metabolism including inhibition of intestinal calcium absorption [7][8][9], inhibition of vitamin D metabolism [10][11][12][13], and changes in target tissue responses to calcitonin and parathyroid hormone in rats [14,151].…”

mentioning

confidence: 99%

Effect of ethane-1-hydroxy-1,1-diphosphonate and vitamin D on bone mineralization

et al. 1979

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Administration of large quantities of ethane-1-hydroxy-1,1-diphosphonate to growing chicks resulted in a decrease in percent bone ash and an increase in percent osteoid. The degree of inhibition of bone mineral accumulation was a function of both duration and quantity of ethane-1-hydroxy-1,1-diphosphonic acid administration. The inhibition of bone mineral accumulation could be partially corrected with administration of 1,25-dihydroxyvitamin D3. Administration of high levels of ethane-1-hydroxy-1,1-diphosphonate also resulted in inhibition of intestinal calcium absorption. This could be reversed or prevented by the administration of 1,25-dihydroxyvitamin D3.

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“…Recent trends (17,18) include the analysis of single tissue layers and cells by using electron microscopy and electron microprobe analysis. Additionally, several current studies (19)(20)(21)(22) reflect increased interest in the effects of organic compounds on trace metal absorption. However, the oxidation and coordination state of the element of interest is rarely determined.…”

Section: Determination Of Levels Of Toxicmentioning

confidence: 99%

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1976

Anal. Chem.

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Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) administration on duodenal calcium transport

Cited by 18 publications

References 31 publications

Diphosphonate Therapy in Nephrocalcinosis

Diphosphonate Therapy in Nephrocalcinosis

Effect of ethane-1-hydroxy-1,1-diphosphonate and vitamin D on bone mineralization

The Search for What and How Much ends with Spectronic®

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