Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy

Nogueira-de-Souza, Naiara Correa; Silva, I. D. C. Guerreiro da; Carvalho, Cristina Valletta de; Pulchinelli, Alvaro; Haidar, Mauro Abi; Baracat, Edmund Chada; Massad-Costa, A. M.

doi:10.1590/s0100-879x2009001200003

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…In fact, the first study done by Herrington et al (37) found a significant association between PvuII SNPs and treatment response to hormone therapy in terms of serum HDL with greater increase in serum HDL in women with PP genotype as compared to Pp or pp. Other small studies have found similar results (44,45). …”

Section: Discussionsupporting

confidence: 81%

“…These SNPs have previously been shown to be associated with bone markers (38), bone mineral density and fractures (39,40) and cardiovascular disease including myocardial infarction (41,42) and stroke (43). Few studies have examined the association of change in serum lipids in response to HT with estrogen receptor alpha gene SNPs (37, 44,45). …”

Section: Introductionmentioning

confidence: 99%

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Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women

Sai

Gallagher²,

Fang

2011

Menopause

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Objective Examine the effect of conjugated equine estrogens alone (ET), conjugated equine estrogens plus medroxyprogesterone (EPT), calcitriol alone, calcitriol plus EPT/ET or placebo on serum lipid profile and analyze the interaction with estrogen receptor alpha gene single nucleotide polymorphisms (ESR-α SNPs) on response to therapy. Methods 489 postmenopausal women > 65 years age enrolled in 3-year double blind placebo-controlled clinical trial Results In both intent to treat and complier (>80% adherent) analysis, there was significant increase in serum high-density lipoproteins (HDL), significant decrease in serum low-density lipoproteins (LDL) and LDL:HDL ratio in all hormone treatment groups compared to placebo (p<0.05). However, serum triglycerides and very low-density lipoproteins (VLDL) increased in EPT and ET+ calcitriol groups' versus placebo (p <0.05). ESR-α SNPs PvuII and XbaI appeared to have a significant effect on response to treatment. Genotypes containing p allele showed significantly greater decrease in serum cholesterol and VLDL than those having P allele in the ET plus calcitriol group (p<0.05) and those with x allele had significantly greater decrease in serum cholesterol in HT plus calcitriol group at the end of 3 years versus X allele and a greater decrease in serum LDL in alleles x versus X in ET plus calcitriol group (p<0.05). Conclusions ET with or without progesterone had a favorable effect on lipid profile in postmenopausal elderly women and this was dependent on estrogen receptor SNP's – PvuII and XbaI. However, this interaction with ESR-α SNPs need to be confirmed in larger studies.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women

Sai

Gallagher²,

Fang

2011

Menopause

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“…Apart from PPARα, another gene related to lipoprotein tissue related, APOB, showed a significantly downregulation upon ESR1 overexpression of [25]. Polymorphisms in ESR1 have been confirmed to be closely associated with human lipoprotein levels [26,27]. Our results demonstrated that the expression of PPARα and APOB significantly decreased in poGCs upon ESR1 overexpression.…”

Section: Discussionsupporting

confidence: 56%

Estrogen Receptor Gene 1 (ESR1) Mediates Lipid Metabolism in Goose Hierarchical Granulosa Cells Rather than in Pre-Hierarchical Granulosa Cells

Ouyang

Xie

Ran

et al. 2023

Biology

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(1) Background: The role of estrogen receptor gene 1 (ESR1) in female reproduction and lipid metabolism has been extensively investigated. However, its contribution to lipid metabolism during the development of poultry follicles remains unclear. (2) Methods: This study aimed to explore the function of ESR1 via overexpressing (ESR1ov) and interfering (ESR1si) with its expression in pre-hierarchical granulosa cells (phGCs) and hierarchical granulosa cells (poGCs). (3) Results: We successfully cloned and obtained an 1866 bp segment of the full-length CDS region of the Sichuan white goose ESR1 gene. In phGCs of the ESR1ov and ESR1si groups, there were no significant changes compared to the control group. However, in poGCs, the ESR1ov group exhibited decreased lipid deposition, triglycerides, and cholesterol compared to the control group, while the ESR1si group showed increased lipid deposition, triglycerides, and cholesterol. The expression of APOB and PPARα was significantly reduced in the ESR1ov group compared to the ESR1ov-NC group. Moreover, significant changes in the expression of ACCα, DGAT1, SCD, CPT1, and ATGL were observed between the ESR1si and ESR1si-NC group. (4) Conclusions: These findings shed light on the function and molecular mechanism of ESR1 in lipid metabolism in goose poGCs, providing a better understanding of the physiological process of goose follicular development.

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Are polymorphisms in oestrogen receptors genes associated with lipid levels in response to hormone therapy?

Smiderle

Mattevi²,

Giovenardi³

et al. 2012

Gynecological Endocrinology

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Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy

Cited by 4 publications

References 32 publications

Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women

Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women

Estrogen Receptor Gene 1 (ESR1) Mediates Lipid Metabolism in Goose Hierarchical Granulosa Cells Rather than in Pre-Hierarchical Granulosa Cells

Are polymorphisms in oestrogen receptors genes associated with lipid levels in response to hormone therapy?

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