Effect of estrogen or insulin-induced hypoglycemia on plasma oxytocin levels in bulimia and anorexia nervosa

Chiodera, P.; Volpi, R.; Capretti, L.; Marchesi, Carlo; d’Amato, L.; Ferri, Alberto; Bianconi, L.; Coiro, V.

doi:10.1016/0026-0495(91)90220-q

Cited by 56 publications

(43 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Normal CSF OX concentrations, instead, have been reported in recovered AN patients (Chiodera et al, 1991). In two different recent papers, Lawson et al (2011Lawson et al ( , 2012 showed that overnight secretion of OX in AN patients was decreased compared with healthy controls and that after a standardized mixed meal mean plasma OX levels were higher in AN than in healthy controls.…”

Section: Oxytocinmentioning

confidence: 96%

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Tortorella

Brambilla

Fabrazzo

et al. 2014

Euro Eating Disorders Rev

View full text Add to dashboard Cite

A large body of literature suggests the occurrence of a dysregulation in both central and peripheral modulators of appetite in patients with anorexia nervosa (AN) and bulimia nervosa (BN), but at the moment, the state or trait-dependent nature of those changes is far from being clear. It has been proposed, although not definitively proved, that peptide alterations, even when secondary to malnutrition and/or to aberrant eating behaviours, might contribute to the genesis and the maintenance of some symptomatic aspects of AN and BN, thus affecting the course and the prognosis of these disorders. This review focuses on the most significant literature studies that explored the physiology of those central and peripheral peptides, which have prominent effects on eating behaviour, body weight and energy homeostasis in patients with AN and BN. The relevance of peptide dysfunctions for the pathophysiology of eating disorders is critically discussed.

show abstract

Section: Oxytocinmentioning

confidence: 96%

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Tortorella

Brambilla

Fabrazzo

et al. 2014

Euro Eating Disorders Rev

View full text Add to dashboard Cite

show abstract

“…Herein, a correlation between oxytocin and estradiol levels could only be recorded in the obese group, likely due to the enhanced aromatase activity associated with obesity [31]. Because oxytocin secretion is clearly affected by mechanism related to the hypothalamus-pituitary-gonadal system and estradiol has been shown to positively modulate oxytocin levels at the central level in animal models [5] and at the peripheral level in humans [39], we are inclined to explain the lack of correlation between oxytocin and estradiol in the whole dataset as the result of the cross-sectional design of our study, the relatively small study sample and, possibly, the use of an enzyme-linked immunoassay instead of the recommended mass spectrometry-based assay for estradiol determination [40]. …”

Section: Discussionmentioning

confidence: 99%

Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables

et al. 2018

View full text Add to dashboard Cite

Objective: To investigate the relationship between oxytocin, menopause and obesity. Methods: A cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM). Results: Women from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post- than in premenopausal women (NW: p < 0.05; OB: p < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5). Conclusions: Obesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.

show abstract

“…Specifically, it has been shown that OXT increased the arousal induced by infant photos in nulliparous women (Rupp et al, 2013) and promoted responsiveness to infant crying and laughter by reducing activation in anxiety-related neural circuits (Riem et al, 2011(Riem et al, , 2012. Clearly, OXT effects in women may vary as a function of steroid hormones, which influence plasma levels of the peptide (Chiodera et al, 1991), regulate the expression of the OXTR gene (Quinones-Jenab et al, 1997) and affect OXTR function through a non-genomic mechanism (Grazzini et al, 1998). In fact, millions of women around the world use steroidbased hormonal contraception (HC) as an effective way of birthcontrol (Alkema et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face

Scheele¹,

Plota²,

Stoffel‐Wagner

et al. 2015

Social Cognitive and Affective Neuroscience

View full text Add to dashboard Cite

The hypothalamic peptide oxytocin (OXT) has been identified as a key modulator of pair-bonding in men, but its effects in women are still elusive. Moreover, there is substantial evidence that hormonal contraception (HC) influences partner preferences and sexual satisfaction, which constitute core domains of OXT function. We thus hypothesized that OXT effects on partner-related behavioral and neural responses could be significantly altered in women using HC. In this functional magnetic resonance imaging study involving 40 pair-bonded women, 21 of whom were using HC, we investigated whether a 24-IU nasal dose of OXT would modulate brain reward responses evoked by the romantic partner's face relative to the faces of familiar and unfamiliar people. Treatment with OXT increased the perceived attractiveness of the partner relative to other men, which was paralleled by elevated responses in reward-associated regions, including the nucleus accumbens. These effects of OXT were absent in women using HC. Our results confirm and extend previous findings in men that OXT interacts with the brain reward system to reinforce partner value representations, indicating a common OXT-dependent mechanism underlying partner attraction in both sexes. This mechanism may be disturbed in women using HC, suggesting that gonadal steroids could alter partner-specific OXT effects.

show abstract

Effect of estrogen or insulin-induced hypoglycemia on plasma oxytocin levels in bulimia and anorexia nervosa

Cited by 56 publications

References 18 publications

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Central and Peripheral Peptides Regulating Eating Behaviour and Energy Homeostasis in Anorexia Nervosa and Bulimia Nervosa: A Literature Review

Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables

Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face

Contact Info

Product

Resources

About