Effect of estrogen on changes in the activity of striatal cholinergic neurons induced by DA drugs

Euvrard, C.; Labrie, Fernand; Boissier, Jacques R.

doi:10.1016/0006-8993(79)90392-5

Cited by 79 publications

(18 citation statements)

References 16 publications

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“…Effects of hyperprolactinaemia, induced by either pituitary grafts or oestrogen, on other central nervous mechanisms have been reported (e.g. Euvrard, Labrie & Boissier, 1979;Euvrard, Oberlander & Boissier, 1980;Hruska, Ludmer & Sibergeld, 1980;Wood, Cheney & Costa, 1980;Nicoletti, Patti, Ferrara et al 1982).…”

Section: Discussionmentioning

confidence: 96%

Effects of hyperprolactinaemia and testosterone on the release of LH-releasing hormone and the gonadotrophins in intact and castrated rats

Brar¹,

McNeilly²,

Fink³

1985

Journal of Endocrinology

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We have investigated the effect of hyperprolactinaemia on the secretion of LH-releasing hormone (LHRH), LH and FSH in male rats of the PVG strain which were left intact, castrated or castrated and then implanted with either a 10 or 30 mm silicone elastomer capsule containing testosterone (T10 and T30 respectively). Hyperprolactinaemia was produced by pituitary grafts under the kidney capsule. Pituitary stalk blood, for LHRH estimation, and peripheral blood, for LH, FSH and prolactin, were collected under alphaxalone anaesthesia. Pituitary stalk blood was collected during three consecutive periods of 30 min each before, during and after the application of an electrical stimulus to the median eminence (ME). Hyperprolactinaemia significantly reduced the plasma concentrations of FSH in intact rats and the post-castration increase in the plasma concentrations of both LH and FSH. Neither hyperprolactinaemia nor castration had any significant effect on the spontaneous output of LHRH, but castration alone or castration plus implantation of a T30 capsule did significantly reduce the increment in LHRH output produced by ME stimulation, an effect not seen in rats bearing pituitary grafts. The T30, but not the T10 capsules suppressed the post-castration increase in the gonadotrophins, and the inhibitory effect of testosterone was not significantly affected by hyperprolactinaemia. An incidental but important finding was that the presence of pituitary grafts under the kidney capsule reduced the anaesthetic dose of alphaxalone by 63%.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 96%

Effects of hyperprolactinaemia and testosterone on the release of LH-releasing hormone and the gonadotrophins in intact and castrated rats

Brar¹,

McNeilly²,

Fink³

1985

Journal of Endocrinology

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“…6,18,40] claim that oestrogens facilitate the actions of dopamine, while others [e.g. 8,10,17,27] report oestro gen to be antidopaminergic. It has been suggested [32] that oestrogens can produce paradoxical results since their effects seem to be both a reduction in the postsynaptic efficacy of dopamine (probably via a reduction in the number of receptors) and also supersensitivity of dopamine receptors upon withdrawal -that is to say, oestrogens can mimic the effects of neuroleptics.…”

Section: Discussionmentioning

confidence: 99%

“…In this study we chose to investigate the two phases which have been categorised [12] as 'preovulatory' (i.e. days 5-13 of a 28-day cycle) and 'premenstrual' (days [26][27][28]. It has been shown [45] that whatever the cycle length, time from ovu lation to menstruation remains fairly constant at 13-15 days.…”

Section: Menstrual Cycle Phasementioning

confidence: 99%

Early Visual Processing over the Menstrual Cycle: The Tilt Aftereffect

et al. 1990

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We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with increased dopaminergic function, compared to data produced in the premenstrual phase, suggesting changes in dopamine function over the cycle.

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“…Evi dence for such a hypothesis includes the reduced striatal DA concentration [11], the increase in stereotyped beha viour following apomorphine administration and the in crease in the number of DA-binding sites in the striatum af ter oestrogen treatment [21,22]. However, the reduction of the response of neostriatal cholinergic neurons to DA by E2 treatment [12] is more difficult to explain by such a mecha nism, as is the reduction in neuroleptic-induced supersensi tivity which follows the administration of oestrogen [17,25,27], 1 We thank Heinz Dick for estimation of the plasma concentra tions of oestradiol in the hypophysectomised male rats. …”

mentioning

confidence: 99%

Oestradiol-17β Increases the Firing Rate of Antidromically Identified Neurones of the Rat Neostriatum

Tansey¹,

Arbuthnott²,

Fink³

et al. 1983

Neuroendocrinology

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Extracellular recordings were made from the neostriatum of rats anaesthetised with halothane. Normal male and female animals were used as well as castrated animals with implants containing oestradiol-17β (E₂). In animals with high levels of circulating oestrogen, intact pro-oestrous rats and females and males bearing an E2 implant, individual units could be recorded that were spontaneously active and with axons that could be excited by stimulation in the crus cerebri. Such antidromically identified striato-nigral neurones were invariably silent in male animals and in ovariectomised females. In contrast to animals in pro-oestrus, intact female animals during metoestrus showed the ‘male’ pattern of striatal cell activity. These results show that E₂ can stimulate spontaneous firing of striato-nigral neurons, and that this action of E2 is not sex-dependent.

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Effect of estrogen on changes in the activity of striatal cholinergic neurons induced by DA drugs

Cited by 79 publications

References 16 publications

Effects of hyperprolactinaemia and testosterone on the release of LH-releasing hormone and the gonadotrophins in intact and castrated rats

Effects of hyperprolactinaemia and testosterone on the release of LH-releasing hormone and the gonadotrophins in intact and castrated rats

Early Visual Processing over the Menstrual Cycle: The Tilt Aftereffect

Oestradiol-17β Increases the Firing Rate of Antidromically Identified Neurones of the Rat Neostriatum

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