Effect of estrogen and antiestrogens on the estrogen receptor content in the cochlea of ovariectomized rats

Stenberg, Annika Elmqvist; Simonoska, Rusana; Stygar, Denis; Sahlin, Lena; Hultcrantz, Malou

doi:10.1016/s0378-5955(03)00136-9

Cited by 24 publications

(13 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors suggest that their results support the hypothesis that estrogen plays an important role in the maintenance of auditory integrity. Similar conclusions have been drawn from the demonstration of estrogen receptors alpha and beta in the inner ear of rodents and humans; the receptors can be down-regulated with antiestrogens (Stenberg et al, 1999(Stenberg et al, , 2001(Stenberg et al, , 2003 and vary in expression in fetal and mature rats during the course of development, maturation and pregnancy (Simonoska et al, 2009).…”

Section: Discussionsupporting

confidence: 69%

The menopause triggers hearing decline in healthy women

Hederstierna¹,

Hultcrantz²,

Collins³

et al. 2010

Hearing Research

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 69%

The menopause triggers hearing decline in healthy women

Hederstierna¹,

Hultcrantz²,

Collins³

et al. 2010

Hearing Research

Self Cite

View full text Add to dashboard Cite

“…24 Estrogen influences hearing ability through its action on estrogen receptors in the inner ear. [25][26][27] Estrogen exerts other effects that may influence hearing ability, such as on the regeneration of cells. 25,28 However, we did not find a significant correlation between the estrogen and hearing levels.…”

Section: Discussionmentioning

confidence: 99%

Hearing loss in Turner syndrome

Morimoto

Tanaka²,

Taiji³

et al. 2006

The Journal of Pediatrics

View full text Add to dashboard Cite

“…In another study [31], ovariectomized rats were administered estrogen, which led to an upregulation of ERs in the stria vascularis. This is an area where water and fluid balances are regulated [32].…”

Section: Rodents Hearing and Estrogenmentioning

confidence: 99%

Estrogen and hearing: a summary of recent investigations

Hultcrantz

Simonoska

Stenberg

2006

Acta Oto-Laryngologica

Self Cite

165

144

View full text Add to dashboard Cite

Is the female sex steroid estrogen the key to preserved hearing in the aging human? This question remains unanswered, but hearing loss is more profound in elderly males than females. There are also well-known sex differences in the auditory brainstem response (ABR), i.e. women have shorter latencies than men. Moreover, menopausal women who are administered hormone replacement therapy have slightly better hearing than those who are not, and women with Turner's syndrome (45,X), who are biologically estrogen-deficient, show longer ABR latencies and early presbyacusis. These findings are also supported by animal experiments. When boosted with estrogen or testosterone the non-reproductive female midshipman fish alters its inner ear auditory mechanism so that it can hear the male's hum-like call. If estrogen receptor beta is knocked out in mice, severe progressive hearing loss occurs, leading to early deafness. In apparent contradiction to these findings, there have been case reports suggesting that hormone replacement therapy and oral contraceptive use can lead to hearing loss, but of another type, namely acute sudden deafness. Such contradictory aspects of the action of estrogen are commonly found and may spring from the fact that there are two estrogen receptors, alpha and beta, both of which are present in the inner ear of mice, rats and humans. Knowing how sex steroids can alter hearing ability may give important clues as to how estrogen can preserve hearing in humans. In this review we present a summary of current knowledge about hearing and estrogen.

show abstract

Effect of estrogen and antiestrogens on the estrogen receptor content in the cochlea of ovariectomized rats

Cited by 24 publications

References 19 publications

The menopause triggers hearing decline in healthy women

The menopause triggers hearing decline in healthy women

Hearing loss in Turner syndrome

Estrogen and hearing: a summary of recent investigations

Contact Info

Product

Resources

About