Effect of estradiol valerate on endometrium thickness during clomiphene citrate‐stimulated ovulation

Satirapod, Chonthicha; Wingprawat, Siripen; Jultanmas, Rattiya; Rattanasiri, Sasivimol; Jirawatnotai, Siwanon; Choktanasiri, Wicharn

doi:10.1111/jog.12130

Cited by 19 publications

(17 citation statements)

References 28 publications

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“…In a study by Satirapod et al, the effects of Estradiol Valerate on the thickness of Clomiphene citrate -stimulated endometrium was examined. They concluded that the administration of Estradiol Valerate following the Clomiphene citrate treatment can prevent the endometrial thinning [13].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Effect of Clomiphene- Estradiol Valerate vs Letrozole on Endometrial Thickness, Abortion and Pregnancy Rate in Infertile Women with Polycystic Ovarian Syndrome

Seyedoshohadaei

Tangestani

Zandvakili

et al. 2016

JCDR

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Section: Discussionmentioning

confidence: 99%

“…The use of drugs to improve endometrial thickness is of interest to researchers [11,12]. Endometrial thickness facilitates the embryo replacement, therefore it reduces the risk of spontaneous abortion and also increase pregnancy rate [13]. Physicians have tried to adjust Clomiphene effects using ethinyl estradiol [14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Clomiphene- Estradiol Valerate vs Letrozole on Endometrial Thickness, Abortion and Pregnancy Rate in Infertile Women with Polycystic Ovarian Syndrome

Seyedoshohadaei

Tangestani

Zandvakili

et al. 2016

JCDR

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“…39,40 Since a thin endometrium is a critical factor for implantation failure, preventing CC induced thinning of the endometrium by adding exogenous estrogens during CC stimulation is important. 8 A relationship between CC treatment and endometrial cancer investigated by many retrospective studies. 41 Ovulation stimulating agents increase serum estradiol levels causing unopposed supraphysiological levels of estrogen during the follicular phase of menstrual cycles of induced ovulation and therefore may also increase uterine cancer risk.…”

Section: Groupsmentioning

confidence: 99%

“…This discrepancy is believed to result from the negative effect of CC on the cervical mucus quality and its antiestrogenic activity on endometrium. [7][8][9] There are several complications of ovulation induction. Functional ovarian cysts have often been observed after ovulation induction.…”

mentioning

confidence: 99%

The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment

Özdemır¹,

Erol²,

Cevrioğlu³

et al. 2015

Turkiye Klinikleri J Med Sci

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lomiphene citrate (CC) a nonsteroidal tissue selective estrogen receptor modulator was approved for clinical use in 1967. [1][2][3] CC is the first line treatment for women with ovulatory disorders who are Turkiye Klinikleri J Med Sci 2015;35(4) 209 The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Clomiphene citrate (CC) a nonsteroidal tissue selective estrogen receptor modulator is used for inducing ovulation. In this study, we aimed to investigate the histopathological changes and dose related effects of long term CC treatment on rat ovary and endometrium. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Four groups of female rats were included in the study. In group 1 (control) only saline was administered whereas in groups 2, 3 and 4 CC was (once a week) administered for 18 weeks at the doses of 1 mg/kg, 4 mg/kg and 8 mg/kg, respectively. Uterus and both ovaries were excised for histopathological evaluation. R Re es su ul lt ts s: : Histopathological examination showed that papillary hyperplasia of the surface epithelium of the ovary was present in all CC treated groups, with the highest percentage and severity in group 4. The mean values of endometrial thickness and endometrial gland diameters in this group were lower than those in groups 1 and 2 (p<0.05). Diameters of ovaries and ovarian surface epithelium in group 4 were decreased with respect to control group (p<0.05). C Co on nc cl lu us si io on n: : High doses and repetitive treatment with CC may have detrimental effects in terms of endometrial thinning and developing precancerous lesions in the ovaries.K Ke ey y W Wo or rd ds s: : Clomiphene; pathology; endometrium; ovary; rats; time Ö ÖZ ZE ET T A Am ma aç ç: : Klomifen sitrat (CC) ovulasyon indüksiyonunda kullanılan, steroid yapıda olmayan, seçici özellikte östrojen reseptör modülatörüdür. Bu çalışmada, uzun süreli CC tedavisinin rat ovaryumu ve endometriyumundaki histopatolojik değişikliklerin uygulanan dozla ilişkisi araştırıldı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma her grupta yedi dişi rat bulunan dört grupta yapıldı. Grup 1'e (kontrol) fizyolojik tuzlu su verilirken grup 2, 3 ve 4'e klomifen sitrat sırasıyla 1 mg/kg, 4 mg/kg ve 8 mg/kg dozlarda 18 hafta boyunca haftada bir kez oral yolla uygulandı. Çalışmanın sonunda uterus ve her iki ovaryum histopatolojik değerlendirmeler için eksize edildi. B Bu ul lg gu ul la ar r: : Histopatolojik çal-ışmalar, klomifen sitrat uygulanan bütün grupların ovaryum yüzey epitellerinde papiller hiperplazi meydana geldiğini gösterdi; grup 4'te papiller hiperplazinin şiddeti ve yüzdesi daha yüksek belirlendi. Bu grupta endometrial bezlerin çapları ve endometrial kalınlıklarının ortalama değerlerinin grup 1 ve grup 2'den daha düşük olduğu bulundu (p<0,05). Grup 4'teki ovaryum yüzey epiteli ve ovaryum çapları da kontrol grubu ile karşılaştırıldığında azaldığı saptandı (p<0,05). S So on nu uç ç: : Yüksek dozda ve uzun süreli...

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“…Estrogen therapy is used as one of the effective factors in the treatment of low endometrial thickness without disorder in folliculogenesis and ovulation 18 . Estrogen is received by estrogen receptor alpha (ER-α), and estrogen prevents endometrial tissue atrophy and helps to grow and increase its thickness 19 -22 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2018

IJPSR

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Endometrial thickness is one of the determinant factors in fertility success. This study was carried out to determine the effects of plants on increasing endometrial thickness and ultimately increasing fertility preservation. Key terms of "endometrium thickness" or "endometrial thickness" or "endometrial lining thickness" in combination with the words "Medicinal plant", "Herb" and "Phyto" were searched on the ISI, PubMed and Scopus databases. Then, the abstracts of the articles, as well as information obtained from other sources about medicinal plants and their derivatives from which their effects directly on endometrial thickness and pregnancy were studied, were selected. Besides, only clinical trials and laboratory studies between 2007 and 2017 were included. The results from this study showed that plants such as Cimicifuga racemosa and Aspalathus lineararis and plant derivatives such as Klimadynon and Icariin and plant formulations such as Xiaoyao powder, Erzhi pill and Siwu decoction can increase fertility in humans or animals by increasing endometrial thickness. Medicinal plants and their derivatives affect the thickness of the endometrium, mainly due to having phytoestrogen and can help maintain the fetus in the uterus and increase fertility preservation. The phytoestrogens available in plants are bound to ER-α receptors and mimics the function of estrogen. However, the effective dose, administration time, endogenous estrogen status and type of herbal prescription or derivatives are of important factors that should be considered in herbal therapy.

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Effect of estradiol valerate on endometrium thickness during clomiphene citrate‐stimulated ovulation

Abstract: We concluded that the addition of 6 mg/day EV following the CC treatment can prevent the endometrial thinning without perturbing folliculogenesis and ovulation.

Cited by 19 publications

References 28 publications

Comparison of the Effect of Clomiphene- Estradiol Valerate vs Letrozole on Endometrial Thickness, Abortion and Pregnancy Rate in Infertile Women with Polycystic Ovarian Syndrome

Comparison of the Effect of Clomiphene- Estradiol Valerate vs Letrozole on Endometrial Thickness, Abortion and Pregnancy Rate in Infertile Women with Polycystic Ovarian Syndrome

The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment

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