Effect of estradiol on tissue glycogen metabolism and lipid availability in exercised male rats

Kendrick, Z. V.; Ellis, G. S.

doi:10.1152/jappl.1991.71.5.1694

Cited by 88 publications

(65 citation statements)

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“…As a result, cellular ATP levels were reduced and the activation status of AMP-Kα, which can regulate that activity of Runx2 (21), was increased. Estrogen favors fatty acid metabolism in a number of tissues (39)(40)(41)(42) and may therefore prevent the switch to glycolytic metabolism in osteoblasts. This idea is worthy of additional study and will likely require the use of models in which estrogen receptor signaling has been modified in the osteoblast lineage.…”

Section: Discussionmentioning

confidence: 99%

“…We speculated that the more severe defect in in vitro maturation induced by E2 treatment of ΔCpt2 osteoblast might be due to an inability to adjust fuel selection, since E2 favors fatty acid utilization in a number of tissues (39)(40)(41)(42). To test this idea, control and ΔCpt2 osteoblast cultured in the presence or absence of E2 were labeled with 2-deoxy-D-[ Figure 3G), suggestive of an adjustment in cellular metabolism to maintain ATP levels.…”

Section: Skeletal Accumulation Of Fatty Acidsmentioning

confidence: 99%

See 1 more Smart Citation

Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner

Kim¹,

Li²,

Zoch³

et al. 2017

JCI Insight

104

101

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Section: Discussionmentioning

confidence: 99%

Section: Skeletal Accumulation Of Fatty Acidsmentioning

confidence: 99%

Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner

Kim¹,

Li²,

Zoch³

et al. 2017

JCI Insight

104

101

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“…Acute short-term (within 2 h) estradiol treatment, similar to the administration for 2 wk, significantly increased neurological dysfunction during insulin bolusinduced hypoglycemia in female ovariectomized rats (1, 42). Glycogen content of cardiac muscle after exhaustive exercise was similarly preserved following 1 h or 6 days of estradiol treatment in male rats (1,20,42). Local microinjection of estrogen into the insular cortex reduced renal sympathetic nerve activity in response to middle cerebral artery occlusion within 10 min (33).…”

mentioning

confidence: 99%

Antecedent short-term central nervous system administration of estrogen and progesterone alters counterregulatory responses to hypoglycemia in conscious male rats

Sandoval¹,

Gong²

2007

American Journal of Physiology-Endocrinology and Metabolism

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aim of this study was to test the hypothesis that antecedent short-term administration of estradiol or progesterone into the central nervous system (CNS) reduces levels of neuroendocrine counterregulatory hormones during subsequent hypoglycemia. Conscious unrestrained male Sprague-Dawley rats were studied during randomized 2-day experiments. Day 1 consisted of an 8-h lateral ventricle infusion of estradiol (1 g/l; n ϭ 9), progesterone (1 g/l; n ϭ 9), or saline (0.2 l/min; n ϭ 10). On day 2, a 2-h hyperinsulinemic (30 pmol ⅐ kg Ϫ1 ⅐ min Ϫ1 ) hypoglycemic (2.9 Ϯ 0.2 mM) clamp was performed on all rats. Central administration of estradiol on day 1 resulted in significantly lower plasma epinephrine levels during hypoglycemia compared with saline, whereas central administration of progesterone resulted in increased levels of plasma norepinephrine and decreased levels of corticosterone both at baseline and during hypoglycemia. Glucagon responses during hypoglycemia were unaffected by prior administration of estradiol or progesterone. Endogenous glucose production following day 1 estradiol was significantly lower during day 2 hypoglycemia, and consequently, the glucose infusion rate to maintain the glycemia was significantly greater after estradiol administration compared with saline. These data suggest that 1) CNS administration of both female reproductive hormones can have rapid effects in modulating levels of counterregulatory hormones during subsequent hypoglycemia in conscious male rats, 2) forebrain administration of reproductive hormones can significantly reduce pituitary adrenal and sympathetic nervous system drive during hypoglycemia, 3) reproductive steroid hormones produce differential effects on sympathetic nervous system activity during hypoglycemia, and 4) reduction of epinephrine resulted in significantly blunted metabolic counterregulatory responses during hypoglycemia. epinephrine; sex differences; reproductive hormones WOMEN, COMPARED WITH MEN, have reduced autonomic responses to psychological stress (22), exercise (8,19,40), and hypoglycemia (14). We have previously shown that women taking estrogen replacement therapy have reduced autonomic counterregulatory activity in response to insulin-induced hypoglycemia compared with age-and body mass index-matched men and women not taking estrogen replacement therapy (35), thus suggesting that chronic elevations in estradiol may be an important mechanism for sexually dimorphic responses to stress.Previous studies have demonstrated that estrogen can have rapid biological effects in the brain and periphery (15,25,31,41). Whether these rapid effects are mediated through the classical estrogen receptors (estrogen receptor-␣ and/or -␤) or nongenomic mechanisms is not understood. In vitro estradiol increases intracellular signaling within minutes (23). In vivo, both centrally and peripherally administered estrogen increases intracellular signaling within the hypothalamus at 6 and 24 h after injection. These signaling changes may mediate a variety of physiological c...

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“…Animal studies demonstrate that estrogens (and perhaps progesterone) enhance the activity of lipoprotein lipase, increase circulating growth hormone-cortisol levels, and decreases circulating insulin levels [2,[15][16][17]. All of these physiological changes result in as increased mobilization of lipid and promote lipolysis [15].…”

Section: Discussionmentioning

confidence: 99%

“…One such category of hormone includes the female sex steroids, estrogens and progesterone. Rodent studies indicate estrogens increase muscle glycogen storage at rest and reduce glycogen utilization during prolonged submaximal exercise, primarily due to the increased oxidation of free-fatty acids as an energy source, which results in a glycogen sparing effect [2]. Human research has been limited in this area, but the findings of several Key words: energy metabolism, menstrual cycle, activity.…”

mentioning

confidence: 99%

The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women.

Hackney¹,

Muoio²,

Meyer³

2000

JJP

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Skeletal muscle glycogen is an essential constituent to exercise performance [1]. Several factors are known to affect glycogen storage and utilization within skeletal muscle, such as dietary practices, exercise activity, and hormonal status [1]. Most research concerning this last factor has dealt with traditional metabolic hormones (e.g., epinephrine, insulin, and glucagon). However, so-called non-metabolic hormones also have an impact upon muscle glycogen and thus could affect exercise performance [1]. One such category of hormone includes the female sex steroids, estrogens and progesterone. Rodent studies indicate estrogens increase muscle glycogen storage at rest and reduce glycogen utilization during prolonged submaximal exercise, primarily due to the increased oxidation of free-fatty acids as an energy source, which results in a glycogen sparing effect [2]. Human research has been limited in this area, but the findings of several Key words: energy metabolism, menstrual cycle, activity. Abstract:In animals, female sex steroid hormones (SS, estrogens-progesterone) influence the energy substrate that is metabolized. Human research on this issue is controversial. This study examined whether changes in circulating SS hormone levels affected the carbohydrate-lipid metabolism during submaximal prolonged (60 min) exercise. Young, physically active females were studied. Four were classified as anovulatoryoligomenorrheic and four were classified as ovulatory-eumenorrheic. Subject responses were pooled to form one group (nϭ8) and then their responses under low (L) and high (H) pharmaceutically manipulated SS hormone conditions were examined. During exercise, the mean oxygen consumption levels were 1.70Ϯ0.10 l · min Ϫ1for L-SS and 1.75Ϯ0.11 l · min Ϫ1 for H-SS (pϭ 0.07), respectively. The respiratory exchange ratio (RER) responses were significantly different during exercise between the conditions: 0.93Ϯ0.04 for L-SS and 0.90Ϯ0.04 for H-SS (pϽ0.05), respectively. RER responses were utilized to calculate substrate oxidation. Significantly less carbohydrate oxidation was found in the H-SS condition as compared to the L-SS condition (pϽ0.05). Lipid oxidation was also significantly different, but for this measure, the levels of oxidation were greater in the H-SS than in the L-SS condition (pϽ0.05). Finally, total energy expenditure for the 60 min of exercise was not significantly different between the hormonal conditions. Results suggest that sex steroid hormones have an impact upon substrate oxidation in women during exercise. Specifically, high circulating concentrations of the SS hormones result in an enhanced reliance upon the oxidation of lipid as an energy substrate and consequently induce a reduction in carbohydrate oxidation. The mechanism inducing this "metabolism shift" appears due to sex steroid hormones directly and indirectly increasing lipid mobilization and lipolysis.

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Effect of estradiol on tissue glycogen metabolism and lipid availability in exercised male rats

Cited by 88 publications

References 0 publications

Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner

Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner

Antecedent short-term central nervous system administration of estrogen and progesterone alters counterregulatory responses to hypoglycemia in conscious male rats

The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women.

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