Effect of estradiol benzoate used at the start of a progestagen treatment on superovulatory response and embryo yield in lactating and non-lactating llamas

Aller, Juan F.; Cancino, Andrea Karina; Rebuffi, G. E.; Alberio, R. H.

doi:10.1016/j.anireprosci.2010.02.001

Cited by 14 publications

(9 citation statements)

References 18 publications

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“…Thus, treatment with the highest content promoted follicular regression and the emergence of a new wave and one follicle was selected and reached ovulatory diameter on average 5 days after device withdrawal. These findings are in agreement with previous reports in llamas treated with intravaginal sponges containing medroxyprogesterone acetate (MAP) for 8 days (Aller et al., ) or injectable P 4 (Santiani et al., ). The latter authors have reported that P 4 injection in llamas induced regression of the dominant follicle and the emergence of a new wave after progesterone effect had ceased.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, IVDs could be reused successfully reducing the costs of treatments (Suarez et al., ; Vilariño, Rubianes, & Menchaca, ). In llamas, the use of an IVD containing 330 mg of P 4 (Chaves et al., ) or intravaginal sponges containing 120 mg of medroxyprogesterone acetate (MAP; Aba, Quiroga, Auza, Forsberg, & Kindahl, ; Aller, Cancino, Rebuffi, & Alberio, ) induced follicular regression regardless of the phase of the follicular wave at the start of treatment. In addition, intramuscular injections of P 4 suppressed follicular development (Santiani, Leyva, & García, ) and ensured the presence of a follicle deemed to ovulate at the end of treatment (Alberio & Aller, ; Carretero, Chaves, Agüero, & Miragaya, ).…”

Section: Introductionmentioning

confidence: 99%

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Hormonal changes and follicular activity after treatment with intravaginal progesterone‐releasing devices in llamas

Cavilla

Bianchi

Aguilera

et al. 2016

Reprod Domestic Animals

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Plasma progesterone (P ) concentrations and follicular activity after administration of different P doses were evaluated in 33 adult female llamas treated with intravaginal devices. In Study 1, a group of llamas (n = 10) was treated with an intravaginal device (IVD) containing 160 (n = 5) or 780 mg of P (n = 5). Based on the results from the first study, in Study 2, females with follicles at different stages of development were treated with the IVD containing 780 mg of P (n = 21) or remain untreated (control; n = 12) to evaluate the effect of P on follicular activity. In Study 1, the IVD containing 160 mg of P induced follicular turnover in 60% of females while the remaining 40% of llamas developed persistent follicles. Thus, this device controlled follicular activity in llamas, although it promotes the persistence of follicles present at start of treatment. Conversely, in both studies, the IVD containing 780 mg of P suppressed follicular development and hasten the emergence of a new follicular wave in all females regardless of the follicular phase at insertion. Additionally, in Study 2, this device effectively concentrated the appearance of follicles with ovulatory diameter at a definite time after treatment in comparison with control animals. In conclusion, treatment with an IVD containing 780 mg of P would be considered for the control of follicular activity in llamas as it ensures the presence of a young follicle with ovulatory diameter by day 6 after the end of treatment in all females.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Hormonal changes and follicular activity after treatment with intravaginal progesterone‐releasing devices in llamas

Cavilla

Bianchi

Aguilera

et al. 2016

Reprod Domestic Animals

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“…Significant differences 4 between number of CL and recovered embryos for DIB and Cronipres groups were similar to that observed by Vaughan et al (2013) in alpacas (r = 0.54). However, no significant correlation (r = 0.12) was detected by Aller et al (2010), possibly as consequence of the high number of ovarian follicles (12.4) induced by the superovulatory treatment; therefore, the ovarian bursa can be displaced leading to a loss of oocytes into the abdominal cavity and a low number of recovered embryos. Plasma P 4 concentrations rose quickly after ID insertion (Day 0) with peak concentration attained on Day 1.…”

Section: Short Communication Open Accessmentioning

confidence: 94%

“…In llamas, Aller et al (2010) observed that the follicular wave emergence occurred approximately on Day 4 (± one day) after medroxiprogesterone acetate intravaginal sponge insertion. Therefore, in the present study the eCG treatment for ovarian stimulation was administered on Day 3 after ID insertion.…”

Section: Acknowledgmentsmentioning

confidence: 99%

Short Communication. Embryo yield in llamas synchronized with two different intravaginal progesterone-releasing devices and superovulated with eCG

Aller¹,

Abalos²,

Acuña³

et al. 2015

Span. j. agric. res.

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The objectives of this study were to compare the effects of two intravaginal devices (ID) containing the same dose (0.5 g) of progesterone (P 4 ) on subsequent ovarian response, embryo production and circulating P 4 concentration profile in llamas (Lama glama) treated with equine chorionic gonadotropin (eCG) for ovarian superstimulation. Female llamas were randomly assigned (n = 10 llamas per group) to one of the following groups and treated (Day 0) with an ID containing 0.5 g of vegetal P 4 to synchronize the emergence of a new follicular wave: i) DIB 0.5 ® and ii) Cronipres M15 ® . On Day 3 llamas were intramuscularly treated with 1000 IU of eCG. The IDs were removed on Day 7. Llamas were naturally mated (Day 9) and treated with GnRH analogue to induce ovulation. A second mating was allowed 24 h later. Embryos were collected between 7 and 8 days after the first mating. Blood samples were taken every day from Day 0 to Day 7 to measure circulating P 4 concentrations. The results indicated that DIB device maintained greater plasma P 4 levels as compared to Cronipres until Day 2. However, the mean (± SD) number of corpora lutea and recovered embryos was not affected (p < 0.05) by the type of ID (5.3 ± 2.6 vs 4.2 ± 2.2 and 3.5 ± 2.7 vs 2.6 ± 3.0 for DIB and Cronipres, respectively). In conclusion, both DIB and Cronipres devices can be successfully used to synchronize the emergence of follicular wave prior to a single dose of eCG in superovulation protocol in llamas.Additional key words: South American camelids; superovulation; hormonal treatment; embryo.

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“…Over the last few years, an increasing interest in the production of meat and fibre in South American Camelids (SAC) has been developed in South America and around the world. The major limitation to further increase the rate of genetic improvement in SAC has been the poor reproductive rate and rather long generation interval of the species (Aller, Cancino, Rebuffi, & Alberio, 2010). Camelids present a long period of gestation (342-350 days) and only deliver one young per year, so the number of offspring a female may have is limited (Carretero, Miragaya, Chaves, Gambarotta, & Agüero, 2010).…”

Section: Introductionmentioning

confidence: 99%

Administration of progesterone BioRelease LA inhibits follicular growth in llamas (Lama glama) regardless of follicle diameter at the start of treatment

Veiga

Trasorras

Bianchi

et al. 2018

Reprod Domestic Animals

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The aims of the study were twofold: first, the comparison of the pharmacokinetics parameters of two doses of Progesterone BioRelease LA, (BioRelease Technologies, Lexington, KY, USA) one of 300 mg and other of 150 mg and their effects on ovarian dynamics in llamas. Based on the results from the first study, the aim of the second study was to evaluate the effect of the doses of 150 mg of progesterone on follicular activity considering the stage of the largest follicle at the beginning of treatment. The results in Study 1 showed that both doses of the formulation induced plasma progesterone concentrations higher than 1 ng/ml during the first 6 days of treatment in all females, progesterone concentrations steadily decline until Day 5 following by a slowly decrease. The total amount of progesterone released during treatment was higher in Group 300 than in Group 150 (p = 0.045). Mean maximum concentrations were 14.9 ± 2.24 and 14.3 ± 2.16 ng/ml for Group A versus Group B (p = 0.58), and they were registered on Day 1.5 ± 0.22 and 1.7 ± 0.34 days, respectively (p = 0.10). None of the animals of Group A showed progesterone concentration below 1 ng/ml during all studied period. The treatment applied in Study 2 was efficient in inhibiting the ovarian follicular dynamics and to start a superestimulatory treatment. The use of progesterone Biorelease LA of 150 mg in comparison with the dose of 300 mg could be more effective in the use of synchronization protocols in llamas for AI or prior to the application of an ovarian superstimulatory treatment.

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Effect of estradiol benzoate used at the start of a progestagen treatment on superovulatory response and embryo yield in lactating and non-lactating llamas

Cited by 14 publications

References 18 publications

Hormonal changes and follicular activity after treatment with intravaginal progesterone‐releasing devices in llamas

Hormonal changes and follicular activity after treatment with intravaginal progesterone‐releasing devices in llamas

Short Communication. Embryo yield in llamas synchronized with two different intravaginal progesterone-releasing devices and superovulated with eCG

Administration of progesterone BioRelease LA inhibits follicular growth in llamas (Lama glama) regardless of follicle diameter at the start of treatment

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