Effect of Essential Unsaturated Fatty Acids on Structure and Function of Catalase at High Glucose Concentration

Mirmiranpoor, Hossain; Hashemi, Payam; Firouzabadi, Fatemeh Dehghani; Alishiri, Niloofar; Rahimzadeh, M.

doi:10.15171/ijep.2017.19

Cited by 2 publications

(2 citation statements)

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“…Results of catalase activity of BuOH and AcOEt extracts and TEBN given in Table showed that the best catalase activity was exhibited by TEBN with 622.289±4.325 μ/mg protein compared to vitamin C (760.320±0.003 μ/mg protein), followed by AcOEt extract (498.954±5.770 μ/mg protein), then BuOH extract (200.668±7.000 μ/mg protein). This finding is in good agreement with literature data showing that unsaturated fatty acids protect functional and structural protection of catalase against damages from the hyperglycemic environment . The decrease of catalase activity may cause the accumulation of the O 2 − , H 2 O 2 or accumulation of hydrogen peroxide that correlates with cancer metastasis, indicating that catalase may play an important role to rescue cells from cancer metastasis.…”

Section: Resultssupporting

confidence: 92%

Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Lee

Azmi

et al. 2020

Chemistry & Biodiversity

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and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, 5019 Monastir, TunisiaThis work investigated the polar (PC: protein, amino acid and metabolite) and non-polar (NPC: fatty acid) compounds and bioactivity characteristics of the EBN harvested from the state of Johor in Malaysia. The electrophoretic gels exhibited 15 protein bands (16-173 kD) with unique protein profile. Amino acids analysis by AccQ·Tag method revealed 18 types of amino acids in EBN. Metabolite profiling was performed using High-Performance Liquid Chromatography coupled with Quadrupole Time-of-Flight Mass Spectrometer (HPLC-QTOF/ MS) technique and a total of 54 compounds belonging to different groups were detected and identified. These findings help to uncover the relation of therapeutic activity of EBN. The EBN was further extracted with AcOEt and BuOH. The AcOEt extract was fractionated into three fractions (F 1 À F 3 ), and the high triglyceride content in F 2 was verified by gC-FID. The three groups of fatty acids discovered in EBN are 48.43 % of poly-unsaturated (PUFA), 25.35 % of saturated fatty acids (SFA) and 24.74 % of mono-unsaturated fat (MUFA). This is the first time to report results ofEBN, BuOH, and AcOEt extracts and of fraction F 2 (TEBN) on their analysis for their antioxidant activities by DPPH, ABTS and catalase assay and for their paraoxonase and anti-tyrosinase activities. The results showed that TEBN exhibited the significant bioactivity in all assays. These findings suggest that TEBN is a good source for natural bioactive compounds in promoting body vigor. Current work widened the content of EBN especially on the triglyceride and also marked the content of specific location (Johor, Malaysia) of EBN origin.[a] IC 50 (mg/mL): the concentration at which 50 % is inhibited. [b] TEBN: Triglycerides of EBN. [c] BHT: butylated hydroxytoluene. [d] u/ mg protein: μmol of H 2 O 2 destroyed/min/mg protein. [e] IU: mM/min. Values were expressed as mean � SD (n = 3), Different letters in columns indicate significant differences among fractions at P < 0.05 (LSD test).

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Section: Resultssupporting

confidence: 92%

Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Lee

Azmi

et al. 2020

Chemistry & Biodiversity

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“…The receptor of 1,25(OH)2D3 stimulates the insulin secretion in pancreatic beta-cells via direct or intracellular Ca way. Some studies showed that vitamin D deficiency was accompanied by a decrease in beta cell function in patients with T2D by decreasing the insulin secretion, insulin and C-peptide response, insulin sensitivity, and glucose tolerance [15,17,18]. A study among Iranian patients with diabetes showed that hemoglobin A1c (HbA1c) level had a significant inverse association with vitamin D3 level [19].…”

Section: Introductionmentioning

confidence: 99%

Association Between Glycemic Control Status and Serum Level of Vitamin D3 in Patients with Type 2 Diabetes: A Cross-Sectional Study

Aliniagerdroudbari

Farhangian

Babaniamansour

et al. 2022

Clinical Diabetology

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Objective: This study aimed to assess the association between glycemic control status and serum levels of vitamin D3 in Iranian patients with type 2 diabetes (T2D). Materials and methods: This was a cross-sectional study on 452 patients with T2D in Tehran, Iran, performed between September 2019 and September 2020. We assessed the diabetes laboratory test and vitamin D3 level in all participants using the Enzymatic Glucose Oxidase method. Data were analyzed using SPSS version 24. Results: a total of 452 patients were enrolled in this study (mean age: 59.4 ± 11.4 years, 63.5% females). Vitamin D deficiency was reported in half of the participants. Deficient vitamin D was significantly associated with higher mean level of hemoglobin A1c, fasting plasma glucose, total cholesterol, and low-density lipoprotein-cholesterol (p < 0.05). Multiple regression showed that the level of vitamin D3 could be a good predictor of hemoglobin A1c after adjusting for confounding variables affecting the hemoglobin A1c (regression coefficient: 0.442, 95% CI, 0.072-0.811, p = 0.063). Conclusions: With the alarming rates of vitamin D deficiency in patients with T2D, there was a significant direct association between vitamin D3 and hemoglobin A1c levels before and after adjusting for the associated

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Effect of Essential Unsaturated Fatty Acids on Structure and Function of Catalase at High Glucose Concentration

Cited by 2 publications

References 20 publications

Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Association Between Glycemic Control Status and Serum Level of Vitamin D3 in Patients with Type 2 Diabetes: A Cross-Sectional Study

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