Effect of essential oils of Syzygium aromaticum and Cinnamomum zeylanicum and their major components on biofilm production in Staphylococcus aureus strains isolated from milk of cows with mastitis

Budri, Paulo Eduardo; Silva, N.C.C.; Bonsaglia, Erika Carolina Romão; Fernandes, Ana Angélica Henrique; Araújo, João Pessoa; Doyama, Júlio Toshimi; Gonçalves, Juliano Leonel; Santos, Marcos Veiga dos; Fitzgerald-Hughes, Deirdre; Rall, Vera Lúcia Mores

doi:10.3168/jds.2015-9442

Cited by 53 publications

(40 citation statements)

References 29 publications

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“…These results oppose to those of previously published reports in that this compound was suggested to reduce biofilm formation by these bacteria. Recently, Budri et al (2015) showed that cinnamaldehyde strongly diminishes biofilm formation by S. aureus ATCC 35983 on both polystyrene and stainless steel surfaces, when tested at 0.199 mg/ml. This effect was also observed when cinnamaldehyde was associated with either biodegradable polymers or nanoparticles (Zodrow et al, 2012; Duncan et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

et al. 2016

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Bacterial resistance to the available marketed drugs has prompted the search of novel therapies; especially in regards of anti-virulence strategies that aim to make bacteria less pathogenic and/or decrease their probability to become resistant to therapy. Cinnamaldehyde is widely known for its antibacterial properties through mechanisms that include the interaction of this compound with bacterial cell walls. However, only a handful of studies have addressed its effects on bacterial virulence, especially when tested at sub-inhibitory concentrations. Herein, we show for the first time that cinnamaldehyde is bactericidal against Staphylococcus aureus and Enterococcus faecalis multidrug resistant strains and does not promote bacterial tolerance. Cinnamaldehyde actions were stronger on S. aureus as it was able to inhibit its hemolytic activity on human erythrocytes and reduce its adherence to latex. Furthermore, cinnamaldehyde enhanced the serum-dependent lysis of S. aureus. In vivo testing of cinnamaldehyde in Galleria mellonella larvae infected with S. aureus, showed this compound improves larvae survival whilst diminishing bacterial load in their hemolymph. We suggest that cinnamaldehyde may represent an alternative therapy to control S. aureus-induced bacterial infections as it presents the ability to reduce bacterial virulence/survival without promoting an adaptive phenotype.

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Section: Discussionmentioning

confidence: 99%

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

et al. 2016

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“…The formation of biofilm is really a complex process involving a variety of environmental factors, such as QS, extracellular polysaccharide, proteases, and other global regulators (Lee, Kim, Ryu, & Lee, 2016). With respect to Staphylococci , the most extensively reported genes involved in biofilm formation are intercellular adhesion genes icaD / icaA , coexpression of which provokes the synthesis of viscous polysaccharide intercellular adhesion or poly‐N‐acetylglucosamine (PIA/PNAG) (Budri et al., 2015). Some S. aureus is ica‐independent, in which the biofilm‐associated protein (Bap) is important for bacterial accumulation (Yadav et al., 2015).…”

Section: Bacterial Biofilmmentioning

confidence: 99%

“…A compound with log p ‐value greater than 3 is defined to have a high membrane affinity, such as carvacrol and thymol, with log p ‐values of 3.62 and 3.30, respectively (Nostro et al., 2007). Additionally, these bioactive compounds can also act as direct bactericidal agents by disturbing membrane‐related proteins, interfering with DNA synthesis, inhibiting ATPase activities, and blocking the electron transfer chains (Budri et al., 2015; Chueca, Pagan, & Garcia‐Gonzalo, 2014). It is generally believed that lipophilic essential oil compounds show a stronger ability to eradicate preformed biofilm of Gram‐positive bacteria.…”

Section: Bacterial Biofilmmentioning

confidence: 99%

Antivirulence properties and related mechanisms of spice essential oils: A comprehensive review

Zhang

Gan

Zhang

et al. 2020

Comp Rev Food Sci Food Safe

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In recent decades, reduced antimicrobial effectiveness, increased bacterial infection, and newly emerged microbial resistance have become global public issues, leading to an urgent need to find effective strategies to counteract these problems. Strategies targeting bacterial virulence factors rather than bacterial survival have attracted increasing interest, since the modulation of virulence factors may prevent the development of drug resistance in bacteria. Spices are promising natural sources of antivirulence compounds owing to their wide availability, diverse antivirulence phytochemical constituents, and generally favorable safety profiles. Essential oils are the predominant and most important antivirulence components of spices. This review addresses the recent efforts of using spice essential oils to inhibit main bacterial virulence traits, including the quorum sensing system, biofilm formation, motility, and toxin production, with an intensive discussion of related mechanisms. We hope that this review can provide a better understanding of the antivirulence properties of spice essential oils, which have the potential to be used as antibiotic alternatives by targeting bacterial virulence. K E Y W O R D Sbiofilm, mechanisms, motility, quorum sensing, spice essential oils, toxin 1018

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“…Lingua plicata, also known as fissured tongue, is a benign idiopathic condition that may increase sensitivity to oral irritants and probably allergens . Eugenol is found in spices such as cinnamon and cloves, and is commonly used in dentistry as an analgesic and antimicrobial agent . Eugenol is also a commonly used fragrance component .…”

Section: Discussionmentioning

confidence: 99%

Eugenol allergy mimicking burning mouth syndrome

2018

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Effect of essential oils of Syzygium aromaticum and Cinnamomum zeylanicum and their major components on biofilm production in Staphylococcus aureus strains isolated from milk of cows with mastitis

Cited by 53 publications

References 29 publications

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

Cinnamaldehyde Inhibits Staphylococcus aureus Virulence Factors and Protects against Infection in a Galleria mellonella Model

Antivirulence properties and related mechanisms of spice essential oils: A comprehensive review

Eugenol allergy mimicking burning mouth syndrome

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