Effect of Esophagoplasty on Structural Reorganization of Colon Transplant

Abstract

We studied ultrastructural reorganization of the colon transplant in delayed period after esophagoplasty. It was found that during functioning of the artificial esophagus, a complex of adaptive and pathologic processes occurs in the mucosa. Focal sclerosis of the mucosa and slight epithelial degeneration with hyperplasia and hypersecretion of goblet cells were found in biopsy specimens with stenosis of the anastomosis. In case of colonopathy of the transplant, more pronounced epithelial degeneration and proliferation accompanied by abundant polymorphocellular stromal infiltration were seen. Deformation of the transplant was characterized by progressive atrophic and sclerotic reorganization of the mucosa. Goblet cells with ultrastructural signs of hypersecretion predominated in the population of epithelial cells of the colon transplant; oligomucus and poorly differentiated cell and colonocytes with signs of alteration and degenerative changes in cytoplasmic organelles were also found.

Cell Reactions in Gastric Tube and Colon Transplants in Stenoses of Esophageal Anastomosis

“…The common features of epithelial cell reorganization in the gastric tube and colonic transplants are realization of its compensatory potential and intensifi cation of the barrier function of the mucosa, which manifest in high secretory activity foveolocytes and goblet cells [3,10]. In gastric glands, degenerative changes of cell oorganelles in specialized glandulocytes were often observed, which can be determined by changed conditions of functioning, denervation, and progressive sclerosis of the transplant.…”

“…Accumulated data about structural modifi cations in different types of transplants during the post-reconstruction period attest to signifi cant differences in the realization of compensatory and adaptive potential under changed conditions of their functioning and the formation of pathological processes in the artifi cial organ [1,3,10]. Structural mechanisms underlying the development of esophageal strictures plasty with visceral transplants performed for benign esophageal pathologies are poorly understood, because the major attention is given to assessing their visual and functional parameters.…”