Effect of Esomeprazole on Nighttime Heartburn and Sleep Quality in Patients with GERD: A Randomized, Placebo-Controlled Trial

Abstract

Esomeprazole reduced nighttime heartburn and GERD-related sleep disturbances and improved sleep quality and work productivity.

Night shift working and its impact on sleep quality, calorie intake, and serum thyroid stimulating hormone level among health-care workers in a tertiary hospital, Bengaluru

“…The PSQI was used to evaluate the sleep quality during the month preceding the study and is widely used in other surveys too. [22,23] Our results were consistent with Rutenfranz et al, [24] who reported that, almost 70% of night shift workers complained of sleep disorders, assessing their sleep as unsatisfactory, insufficient, and little restorative.…”

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

“…34 Several studies have also shown that the response rate of PPI once daily for nighttime heartburn is significantly lower (up to 53%) than the response rate for daytime heartburn (up to 66%). 35,36 In summary, nighttime heartburn has the most important impact on the quality of life for GERD patients. However, night-time heartburn appears to be less responsive to antireflux treatment than daytime heartburn.…”

Employers Need to Have a Wider Horizon Than Drug Costs Alone When Considering the Implementation of Health Care Intervention Programs

“…12 Considerably higher levels of reduced work productivity have been observed in untreated patients with troublesome GERD symptoms [13][14][15][16] ; in those with GERD-related sleep disturbance, for example, the mean reduction in productivity was up to 40%. 16 PPI therapy to resolve GERD symptoms helps to address this burden and improves work productivity.…”

“…12 Considerably higher levels of reduced work productivity have been observed in untreated patients with troublesome GERD symptoms [13][14][15][16] ; in those with GERD-related sleep disturbance, for example, the mean reduction in productivity was up to 40%. 16 PPI therapy to resolve GERD symptoms helps to address this burden and improves work productivity. 15,16 Further, a casecontrol study using objective measurements of hourly and annual at-work productivity confirms that GERD, indeed, has a significant impact on productivity while at work, 17 which supports validity of patient-reported productivity assessments.…”

“…16 PPI therapy to resolve GERD symptoms helps to address this burden and improves work productivity. 15,16 Further, a casecontrol study using objective measurements of hourly and annual at-work productivity confirms that GERD, indeed, has a significant impact on productivity while at work, 17 which supports validity of patient-reported productivity assessments. Assuming an average reduction in at-work productivity of around 10% in the PPI study population (281,951 + 374 = 282,325) and a 40-hour work week, this would correspond to more than 50 million work hours per year in lost at-work productivity due to GERD.…”