Effect of esomeprazole on lipid profile in patients with peptic ulcer

Abdullah, Eman; Dhiaa, Sarraa; Saleh, Khalaf; Merkhan, Marwan M.

doi:10.3897/pharmacia.68.e70292

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…The biochemical findings of renal and liver function tests together with histological study revealed that propolis has provided a protection against modulation induced by isoniazid and rifampicin though measured parameters. Drug side effects on various vital organs has been reported, antipsychotics affect immunity (18), allopurinol on metabolic parameters (19) and thyroid function (20), statins on platelets (21) and metabolic parameters (22), antidiabetics on thyroids (23), non-steroidal anti-inflammatory drugs on gastric mucosa (24), proton-pump inhibitors on kidneys (25) and metabolic parameters (26). These effects depicted in our locality and using propolis as an add-on therapy might restore the defective actions.…”

Section: Discussionmentioning

confidence: 99%

Propolis-Induced Hepatorenoprotection In rodents Exposed to Rifampicin and Isoniazid

Abdulsallam¹,

Thanoon²,

Abduljabbar³

2023

Mil. Med. Sci. Lett.

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The elimination of most drugs based on liver/renal excretion; making liver and kidneys the commonest target organ for exposure to toxic materials. Long-term use of drugs surpassed the effect and aggravate the toxicity. Tuberculosis (TB) is chronic disease with long-term therapy and the deleterious impact of antitubelculosis is certain. Various pharmacokinetic manoveuors were proposed to avoid the potential harmful effect of TB therapy. The present study aimed at mitigating the destructive effects of TB therapy using propolis. To do so, rats were exposed to isoniazid or rifampicin or a combination of them in groups of 8 rats each for a period of 8-weeks these groups were matched with similar group with a propolis ad-on therapy. These results were compared to propolis-free negative control group and positive propolis-treated group. The histological and laboratory findings confirmed that isoniazid or rifampicin or a combination of them jeopardized hepatorenal function and induced deleterious damage. However, isoniazid has shown more intensive deleterious effect compared to rifampicin. Nonetheless, propolis restore the quasi-equilibrium status for kidney and liver via restoring its normal architecture and functionality. To sum up, the potential defect of anti-TB was restored via using propolis as add-on therapy, we do advise using propolis as an adjuvant TB therapy in critically-ill and clinical cases required long-term TB therapy.

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Section: Discussionmentioning

confidence: 99%

Propolis-Induced Hepatorenoprotection In rodents Exposed to Rifampicin and Isoniazid

Abdulsallam¹,

Thanoon²,

Abduljabbar³

2023

Mil. Med. Sci. Lett.

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“…Additionally, the activity of both extracts was more in yeast than in bacteria. 22 As an antioxidant, extract of these plants could find an application in a wide range of chronic diseases which are associated with oxidative stress, such as, diabetes, [23][24][25][26] hyperlipidemia, 27,28 metabolic syndromes, 29 ulcerative diseases, [30][31][32][33] and thyroid disorders. 34 The potency of these plant extracts could be comparable to commonly used antioxidant vitamins in terms of potential therapy.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Comparative Studies, Antioxidant and Antimicrobial of Artemisia and Star Anise

Abid¹,

Abachi²

2023

Pharmacogn J.

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The tradition of investigating plants and extensively scrutinizing their biologically or pharmacologically active compounds has markedly increased due to their fewer adverse effects compared to synthetic drugs. Through this study, we aim to establish a phytochemical screening and analyze and compare the antioxidant and antimicrobial properties of Artemisia and star anise. The antioxidant characteristics of plant extracts we assessed, the chemical bonds and components composition were analyzed in the sample and further experiments were done to assess the antimicrobial activities. On the results, we found that all the extracts of both the species were very impactful in the inhibition of E. coli, C. Albicans, and S. aureus. However, S. aureus was more sensitive to star anise and E. coli and C. albicans were inhibited better through the alcoholic extracts of Artemisia vulgaris. Star anise has a higher and more effective antioxidant activity against DPPH with a calculated value of 78.3 % at a concentration of 750 ppm, at a concentration of 500 ppm it was 65.3% and in the least concentration of 250 ppm, it was 23.3% compared to Artemisia vulgaris. Additionally, both extracts possessed marked antifungal action.

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“…The beneficial outcome of the present study induced by beta carotene should be considered in the protection of renal system from the destructive effects of other chronically used drugs, if any. For example, statins (41,42), proton-pump inhibitors (43,44), CNS drugs (45,46), chemotherapeutic agents (47,48), drug used for diabetes (49,50). Moreover, the same positive effects obtained from beta carotene could be provided by other harmless OTC drugs, such as, vitamins (51,52), or minerals (53,54), or herbal remedies (55) or xanthine oxidase inhibitors (allopurinol) (56,57).…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Beta Carotene Against Amikacin Induced Nephrotoxicity

Khalaf¹,

Althanoon²

2023

Mil. Med. Sci. Lett.

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Background:The rapid loss of kidney function is known as nephrotoxicity. The harmful effects of medications may cause this. Amikacin-related nephrotoxicity is an excellent illustration of such a case. Amikacin is a synthetic aminoglycoside that works against the majority of gram-negative bacteria and, in some circumstances, can be harmful to the kidneys. One of the many methods used to prevent or decrease this toxicity is the use of antioxidant substances with amikacin. Beta carotene is an antioxidant carotenoid pigment. The aim of the current study: is to illustrate the ameliorative effect of beta carotene against the nephrotoxicity caused by amikacin when given before or during the treatment of amikacin. The study also evaluates the nephrotoxicity evoked by amikacin. Material and Methods: Five groups of animals were used (seven rats in each group): the control group, the amikacin group, the beta carotene group, the beta carotene with the amikacin group, and the group given beta carotene first, then added amikacin later together with the beta carotene. Results:The results of the current study demonstrate that when comparing the amikacin-treated group to the control group, there was a significant elevation (p ˂ 0.05) of serum creatinine and urea levels. The results also showed that when comparing the amikacin -treated group to the group treated with beta carotene during amikacin treatment for 14 days, there was a significant reduction (p ˂ 0.05) in serum creatinine and urea levels. Furthermore, in comparison of the amikacin -treated group to the group treated with beta carotene only for 9 days and continued with amikacin for 14 days, there was a significant reduction (p ˂ 0.05) in serum creatinine and urea levels. Also, there were significant decreases (near normal) in serum creatinine and urea. Histological findings confirmed these findings; there was damage to renal tissue in the amikacin -treated group, whereas groups treated with beta carotene and amikacin showed improvements in histological images. Discussion and conclusion: According to the results of renal function tests and histological findings, treatment with AMK only causes renal toxicity in rats, and when rats are treated with BC before and during AMK treatment or even only during AMK treatment, BC can prevent this renal toxicity by decreasing serum urea and creatinine levels, which, in agreement with the previous study, leads us to conclude that BC offers significant protection against AMK-induced nephrotoxicity, The results also showed the efficiency of two methods of administration of beta carotene in giving the required protection against renal toxicity (not preferring one method over the other).

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Effect of esomeprazole on lipid profile in patients with peptic ulcer

Cited by 7 publications

References 18 publications

Propolis-Induced Hepatorenoprotection In rodents Exposed to Rifampicin and Isoniazid

Propolis-Induced Hepatorenoprotection In rodents Exposed to Rifampicin and Isoniazid

Phytochemical Comparative Studies, Antioxidant and Antimicrobial of Artemisia and Star Anise

The Protective Effect of Beta Carotene Against Amikacin Induced Nephrotoxicity

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