Effect of escitalopram on the processing of emotional faces

Alves-Neto, W.C.; Guapo, Vinicius Guandalini; Graeff, Frederico Guilherme; Deakin, Bill; Del-Ben, Cristina Marta

doi:10.1590/s0100-879x2010005000007

Cited by 15 publications

(8 citation statements)

References 15 publications

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“…Escitalopram facilitated the recognition of sadness and inhibited the recognition of happiness in male, but not female, faces. These results confirm that serotonin modulates the recognition of emotional faces, and suggest that the gender of the face subject can play a role in this modulation (Alves-Neto et al, 2010). Based on these findings, the facial expression recognition test represents an innovative model suitable for studying old and new antidepressant drugs in healthy volunteers.…”

Section: Facial Expression Recognition Tasksupporting

confidence: 65%

Drug Experimentation in Healthy Volunteers

Gori¹,

Pasqualetti²,

Castiglioni³

et al. 2011

Drug Development - A Case Study Based Insight Into Modern Strategies

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Section: Facial Expression Recognition Tasksupporting

confidence: 65%

Drug Experimentation in Healthy Volunteers

Gori¹,

Pasqualetti²,

Castiglioni³

et al. 2011

Drug Development - A Case Study Based Insight Into Modern Strategies

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“…Faces were presented in random order for 500ms then replaced by a blank screen, during which participants had an unlimited time to select the expression on the face by pressing one of seven labeled keys. Happy and surprise faces were combined to create a score for Positive faces(as they show similar effects opposite to those of the negative faces both in previous studies(38, 39) and in the current dataset; Table ST2), and sadness, fear, anger, and disgust were combined to create a score for Negative faces, as has been previously used as primary outcome measures(40). Accuracy and reaction times for correct responses were measured and entered into a linear mixed effects model with the fixed factors of visit(Baseline, Follow-up), emotion(Positive, Negative), and group(Experimental, Control).…”

Section: Methodsmentioning

confidence: 90%

Real-Time Functional Magnetic Resonance Imaging Amygdala Neurofeedback Changes Positive Information Processing in Major Depressive Disorder

Young

Misaki

Harmer

et al. 2017

Biological Psychiatry

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Background In participants with major depressive disorder(MDD) trained to upregulate their amygdala hemodynamic response during positive autobiographical memory recall with real-time fMRI neurofeedback(rtfMRI-nf) training, depressive symptoms diminish. This study tested whether amygdala rtfMRI-nf also changes emotional processing of positive and negative stimuli in a variety of behavioral and imaging tasks. Method Patients with MDD completed two rtfMRI-nf sessions(18 received amygdala rtfMRI-nf, 16 received control parietal rtfMRI-nf). One week prior-to and following rtfMRI-nf training participants performed tasks measuring responses to emotionally valenced stimuli including a backward masking task(BMT), which measures the amygdala hemodynamic response to emotional faces presented for traditionally subliminal duration and followed by a mask, and the Emotional Test Battery(ETB) in which reaction times and performance accuracy are measured during tasks involving emotional faces and words. Results During the BMT, amygdala responses increased while viewing masked happy faces, but decreased to masked sad faces in the experimental versus control group following rtfMRI-nf. During the ETB, reaction times decreased to identification of positive faces and during self-identification with positive words, and vigilance scores increased to positive faces and decreased to negative faces during the face dot-probe task in the experimental versus control group following rtfMRI-nf. Conclusions rtfMRI-nf training to increase the amygdala hemodynamic response to positive memories was associated with changes in amygdala responses to happy and sad faces and improved processing of positive stimuli during performance of the ETB. These results may suggest that amygdala rtfMRI-nf training alters responses to emotional stimuli in a manner similar to antidepressant pharmacotherapy.

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Section: Discussionmentioning

confidence: 99%

“…65, 66, 67 In addition, it is thought that changes in serotonergic neurotransmission can modulate identification of emotional faces, particularly fearful faces. 65, 66 Recently, the PCLO risk allele was found to enhance the biological response to SSRIs among MDD patients. 23 However, the mechanism of PCLO modulation on serotonin transmission is unclear and may not involve the serotonin transporter, also in view of the inconsistent findings associated with other serotonergic polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

Piccolo genotype modulates neural correlates of emotion processing but not executive functioning

et al. 2012

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Major depressive disorder (MDD) is characterized by affective symptoms and cognitive impairments, which have been associated with changes in limbic and prefrontal activity as well as with monoaminergic neurotransmission. A genome-wide association study implicated the polymorphism rs2522833 in the piccolo (PCLO) gene—involved in monoaminergic neurotransmission—as a risk factor for MDD. However, the role of the PCLO risk allele in emotion processing and executive function or its effect on their neural substrate has never been studied. We used functional magnetic resonance imaging (fMRI) to investigate PCLO risk allele carriers vs noncarriers during an emotional face processing task and a visuospatial planning task in 159 current MDD patients and healthy controls. In PCLO risk allele carriers, we found increased activity in the left amygdala during processing of angry and sad faces compared with noncarriers, independent of psychopathological status. During processing of fearful faces, the PCLO risk allele was associated with increased amygdala activation in MDD patients only. During the visuospatial planning task, we found no genotype effect on performance or on BOLD signal in our predefined areas as a function of increasing task load. The PCLO risk allele was found to be specifically associated with altered emotion processing, but not with executive dysfunction. Moreover, the PCLO risk allele appears to modulate amygdala function during fearful facial processing in MDD and may constitute a possible link between genotype and susceptibility for depression via altered processing of fearful stimuli. The current results may therefore aid in better understanding underlying neurobiological mechanisms in MDD.

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Effect of escitalopram on the processing of emotional faces

Cited by 15 publications

References 15 publications

Drug Experimentation in Healthy Volunteers

Drug Experimentation in Healthy Volunteers

Real-Time Functional Magnetic Resonance Imaging Amygdala Neurofeedback Changes Positive Information Processing in Major Depressive Disorder

Piccolo genotype modulates neural correlates of emotion processing but not executive functioning

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