Effect of Epinephrine and Physostigmine on the Response of Striated Muscle to Acetylcholine and Potassium

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Some effects produced by adrenaline upon neuromuscular propagation in rats

“…When this is suppressed by ergotoxine, the potentiation is revealed. This is in agreement with the observations of Dale & Gaddum (1930), Burn (1945), Torda & Wolff (1946), Ellis & Beckett (1955) and Hutter & Loewenstein (1955), which were based mostly on experiments with muscles in vitro.…”

Action of adrenaline on synaptic transmission and on adrenal medullary secretion

“…Various hypotheses have been suggested to explain this complex phenomenon (Torda & Wolff, 1946): they include reduction of serum cholinesterase (Tsuji, 1932) and changes in the extracellular concentration of potassium. It has also been suggested that adrenaline, by favouring the production of lactic acid and the reconstitution of phosphagen (Nachmansohn, Waizer & Lipmann, 1936), causes changes in the effector apparatus which increase its sensitivity to acetylcholine.…”