Effect of Epigenetic Modifiers on Fermentation Parameters of Endophytic Fungi from Plants Growing in Uzbekistan

Gulyamova, T.G.; Abdulmyanova, L.I.; Ruzieva, D. M.; Rasulova, Gulchehra; Yusupov, Ulugbek; Sattarova, R. S.

doi:10.20546/ijcmas.2019.803.102

Cited by 6 publications

(3 citation statements)

References 15 publications

(18 reference statements)

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“…Other studies selected for this review did not show for the extracts any antimicrobial activity greater than that of the control (GULYAMOVA et al, 2019;LIMA et al, 2018;WU et al, 2019a;ZHANG et al, 2019a;ZHAO et al, 2018;ZUTZ et al, 2017).…”

Section: Epigenetic Modulation In the Production Of Fungal Antimicrob...mentioning

confidence: 92%

Epigenetic Modulation in the Production of Fungal Antimicrobials: A Systematic Review

Araújo,

De Souza,

Da Silva

et al. 2023

Rev. Foco

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Fungal bioactive compounds can be used by pharmaceutical, agricultural or food industries, and their discovery and identification is closely linked to the methodologies applied in the process. The current knowledge of filamentous fungi genome mining has shown that many genes encoding biosynthetic pathways are silenced, thus limiting their ability to produce metabolites under commonly used laboratory conditions. These biosynthetic pathways may produce substances with antimicrobial potential, but more specific conditions are needed for their activation. This review article shows that the treatment of these fungi with epigenetic modulators such as DNA methyltransferase (DNMT) inhibitors and/or histone deacetylase (HDAC) inhibitors is an approach capable of triggering activation of biosynthetic pathways previously silenced epigenetically. Due to the extensive metabolic diversity of filamentous fungi, epigenetic chromatin modulation appears to be an innovative methodology that can lead to great discoveries in the field of bioprospecting of compounds, not only antimicrobials, as well as to the proven possibility of maximizing the production of known compounds.

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Section: Epigenetic Modulation In the Production Of Fungal Antimicrob...mentioning

confidence: 92%

Epigenetic Modulation in the Production of Fungal Antimicrobials: A Systematic Review

Araújo,

De Souza,

Da Silva

et al. 2023

Rev. Foco

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“…These compounds, including syringic acid, sinapic acid, and acetosyringone, exhibit potent antiproliferative activity against the HepG2 cancer cell line [ 334 ]. Quercetin, an epigenetic modifier, has been found to significantly induce the production of vinblastine in endophytic fungi derived from Vinca plants, namely Penicillium concavoradulozum VE89L and Aspergillus amstelodami VR177L [ 335 ]. Co-culturing the endophytic fungus Aspergillus versicolor KU258497 with the bacterium Bacillus subtilis 168 trpC2 has resulted in the discovery of two new 1-tetralone derivatives, aspvanicin A and aspvanicin B, along with other known compounds.…”

Section: Current Progress With Regards To In Vivo ...mentioning

confidence: 99%

Endophytic fungi: A future prospect for breast cancer therapeutics and drug development

Varghese,

Jisha,

Rajeshkumar

et al. 2024

Heliyon

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“…Quercetin, which was at a concentration of 100 μM, induced the biosynthesis of vinblastine ( 462 ) as a target product in the endophytic fungi Aspergillus amstelodami VR177L and Penicillium concavoradulozum VE89L [ 142 ].…”

Section: Effects Of Histone Deacetylase Modifiersmentioning

confidence: 99%

Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers

Xue

Hou

et al. 2023

JoF

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Genomic analysis has demonstrated that many fungi possess essential gene clusters for the production of previously unobserved secondary metabolites; however, these genes are normally reduced or silenced under most conditions. These cryptic biosynthetic gene clusters have become treasures of new bioactive secondary metabolites. The induction of these biosynthetic gene clusters under stress or special conditions can improve the titers of known compounds or the production of novel compounds. Among the inducing strategies, chemical-epigenetic regulation is considered a powerful approach, and it uses small-molecule epigenetic modifiers, which mainly act as the inhibitors of DNA methyltransferase, histone deacetylase, and histone acetyltransferase, to promote changes in the structure of DNA, histones, and proteasomes and to further activate cryptic biosynthetic gene clusters for the production of a wide variety of bioactive secondary metabolites. These epigenetic modifiers mainly include 5-azacytidine, suberoylanilide hydroxamic acid, suberoyl bishydroxamic acid, sodium butyrate, and nicotinamide. This review gives an overview on the method of chemical epigenetic modifiers to trigger silent or low-expressed biosynthetic pathways to yield bioactive natural products through external cues of fungi, mainly based on the research progress in the period from 2007 to 2022. The production of about 540 fungal secondary metabolites was found to be induced or enhanced by chemical epigenetic modifiers. Some of them exhibited significant biological activities such as cytotoxic, antimicrobial, anti-inflammatory, and antioxidant activity.

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Effect of Epigenetic Modifiers on Fermentation Parameters of Endophytic Fungi from Plants Growing in Uzbekistan

Cited by 6 publications

References 15 publications

Epigenetic Modulation in the Production of Fungal Antimicrobials: A Systematic Review

Epigenetic Modulation in the Production of Fungal Antimicrobials: A Systematic Review

Endophytic fungi: A future prospect for breast cancer therapeutics and drug development

Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers

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