Effect of (−)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines

Taniguchi, Shun’ichiro; Fujiki, Hirota; Kobayashi, Hiroaki; Go, Hiroki; Miyado, Kenji; Sadano, Hiroyuki; Shimokawa, Rie

doi:10.1016/0304-3835(92)90212-e

Cited by 203 publications

(124 citation statements)

References 7 publications

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“…TP are major constituents of green tea extract and exert various physiological effects, such as anti-viral (Nakayama et al, 1991) and anti-cancer (Fujita et al, 1989;Agarwal et al, 1992;Taniguchi et al, 1992;Gao et al, 1994) activities, In addition, they exert anti-allergic activity by inhibiting the release of chemical mediators such as histamine and leukotriene B4 (LTB4) from rat peritoneal exudate cells (Matsuo et al, 1996). Because LTB4 stimulates the lgE production of B Iymphocytes by enhancing the expression and release of soluble CD23 (Yamaoka et ed, 1989;Dugas et al, 1990), the inhibition of LTB4 production by TP may affect the lgE productivity of B cells.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Tea Extracts and Phenolic Components on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats.

Yamada

Watanabe

Kaku

et al. 1997

FSTI

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We examined the effect of tea extracts on immunoglobulin (Ig) production of mesenteric lymph node lymphocytes of Sprague-Dawley rats and found that various extracts suppressed the production of lgA, IgG, and lgM. In addition, the original extracts of green and black teas strongly enhanced lgE production, and their 10' or 103 times diluted samples exerted an inhibitory effect. Similarly, tea polyphenols having a triphenol group enhanced lgE production at I mM and inhibited it at concentrations below 100 pM. On the contrary, diphenolic epicatechin did not affect lgE production. Though all tea polyphenols exerted inhibitory effect on the production of lgA and lgG at concentrations above 10 pM, triphenolic compounds, such as epigallocatechin gallate, gallic acid and pyrogallol, exerted an enhancing tendency on lgA production at 0.1 pM. These results suggest that the lg production-regulating activity of tea extract is partly due to tea polyphenols, especially those having a triphenol group.

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Section: Discussionmentioning

confidence: 99%

“…Among green tea components, tea polyphenols (TP) have been reported to have anti-viral (Nakayama et al, 1991) and anti-tumor (Fujita et al, 1989;Agarwal et al, 1992;Taniguchi et al, 1992) activities. In addition, they exert an anti-allergic effect through the inhibition of chemical mediator release from rat peritoneal exudate cells (Matsuo et al, 1996).…”

mentioning

confidence: 99%

Effect of Tea Extracts and Phenolic Components on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats.

Yamada

Watanabe

Kaku

et al. 1997

FSTI

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“…Furthermore, administration of EGCG inhibits the metastasis of mouse B16 melanoma cells [112]. The adhesion of mouse lung carcinoma cells to endothelial cells is also inhibited by EGCG.…”

Section: Egcgmentioning

confidence: 95%

The roles of polyphenols in cancer chemoprevention

2006

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Abstract.Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative diseases. The ROS-induced development of cancer involves malignant transformation due to altered gene expression through epigenetic mechanisms as well as DNA mutations. Considerable attention has been focused on identifying naturally occurring antioxidative phenolic phytochemicals that are able to decrease ROS levels, but the efficacies of antioxidant therapies have been equivocal at best. Several studies have shown that some antioxidants exhibit prooxidant activity under certain conditions and potential carcinogenicity under others, and that dietary supplementation with large amounts of a single antioxidant may be deleterious to human health. This article reviews the intracellular signaling pathways that respond to oxidative stress and how they are modulated by naturally occurring polyphenols. The possible toxicity and carcinogenicity of polyphenols is also discussed.

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“…It is possible that tea polyphenols (including catechins) suppress tumor metastasis (Taniguchi et al, 1992;Menon et al, 1999). However, little is known about whether food ingredients can inhibit tumor progression.…”

Section: Resultsmentioning

confidence: 99%

“…Other researchers have also examined the anti-metastatic effects of food ingredients in vivo (Taniguchi et al, 1992;Menon et al, 1999). One of the ingredients, epigallocatechin gallate, effectively reduced the spontaneous metastasis of B16 melanoma following 21 days of continuous oral administration after the amputation (Taniguchi et al, 1992).…”

Section: Resultsmentioning

confidence: 99%

6-(Methylsulfinyl)hexyl Isothiocyanate Isolated from Wasabi(Wasabia japonica MATSUM)Suppresses Tumor Progression in an Experimental Mouse System

Fuke

Higashi

Nagata

et al. 2003

FSTR

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We examined the anti-metastatic effect of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) isolated from wasabi (Wasabia japonica MATSUM). Pulmonary micrometastasis was quantified using a dependable method to detect the human c-Ha-ras gene, which was carried in the tumor cell line. Mice belonging to the S-1 group were administered 6-MITC continuously for 35 days from the time of tumor cell inoculation, and S-2 group mice were administered 6-MITC for 21 days from the day of amputation. Oral administration of 200 M 6-MITC solution was effective in preventing metastasis of the experimental tumor. In the S-1 group, 7 out of ten experimental mice have lungs carrying no detectable human c-Ha-ras gene. Amplified human c-Ha-ras bands were detected in only the lungs of three mice; in these, the metastatic indexes of the lungs were respectively 0.60, 0.70 and 0.90. In the S-2 group, the bands were detected in four lungs of 5 experiments, with the metastatic indexes of the lungs in the range 0.36-0.72. Starting the treatment at the time of tumor cell inoculation was more effective in preventing metastasis than beginning the treatment on the day of amputation.

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Effect of (−)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines

Cited by 203 publications

References 7 publications

Effect of Tea Extracts and Phenolic Components on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats.

Effect of Tea Extracts and Phenolic Components on Immunoglobulin Production by Mesenteric Lymph Node Lymphocytes of Sprague-Dawley Rats.

The roles of polyphenols in cancer chemoprevention

6-(Methylsulfinyl)hexyl Isothiocyanate Isolated from Wasabi(Wasabia japonica MATSUM)Suppresses Tumor Progression in an Experimental Mouse System

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