“…Currently, the manufacture of 1 g of a biopharmaceutical agent requires approximately 65 liters of water for injection (wfi), using expensive, high quality water costing s2.00 per liter. In the food [1], steel [2], textile [3], and electronic industries, strategies have been developed to reduce buffer/water consumption by as much as 90%. Consider a scenario projecting the manufacture of 10 000 kg of biopharmaceutical proteins.…”