Effect of Environmental Exposure to Cadmium on Pregnancy Outcome and Fetal Growth: A Study on Healthy Pregnant Women in China

Zhang, Yali; Zhao, Yanyan; Wang, Jixian; Zhu, Hao; Liu, Qingfen; Fan, Yaguang; Wang, Nai-Fen; Zhao, Jinhui; Liu, Husheng; Li, Ouyang; Liu, Aiping; Fan, Ting-Jun

doi:10.1081/lesa-200026331

Cited by 22 publications

(37 citation statements)

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“…Few reports exist of CBCd levels; only some data exist of blood Cd levels in children worldwide (Table 6). Of note, the CBCd and PCd levels in neonates from Guiyu were higher than those in neonates from most other cities in China and were higher than those in neonates from other countries (Fischer et al 2003; Galicia-García et al Hua et al 2006;Maervoet et al 2007;Moon et al 2003;Zhang et al 2004;Zhu et al 2005).…”

Section: Discussionmentioning

confidence: 87%

Assessment of cadmium exposure for neonates in Guiyu, an electronic waste pollution site of China

Huo

Liu

et al. 2010

Environ Monit Assess

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This study aimed to determine the levels of placental cadmium (PCd) and cord blood cadmium (CBCd) and the resulting expression of placental metallothionein (MT) in neonates and to investigate cadmium (Cd) exposure levels in neonates and mothers who live in Guiyu, China, an electronic waste (e-waste) pollution site. Among the 423 mothers included in the study from 2004/2005 to 2007, 289 lived in Guiyu (exposed group) and 134 lived in Chaonan, located 10 km away from Guiyu (controls) and had never been exposed to e-waste pollution. CBCd and PCd levels were measured by atomic absorption spectrometry. Placental MT was examined by immunohistochemistry. Information on maternal and neonatal characteristics and exposure conditions was obtained from hospital records and by personal interviews. For the 3 years, the median CBCd was higher for Guiyu neonates than for controls (3.61 vs. 1.25 μg/L), with 25.61% of Guiyu subjects exhibiting a median CBCd that exceeded the safety limit defined by the World Health Organization (5 μg/L), as compared with 14.18% of control neonates (p < 0.01). In Guiyu, the mean PCd was higher than that for controls (0.17 ± 0.48 vs. 0.10 ± 0.11 μg/g, p ≤ 0.01). The high levels of CBCd and PCd were significantly associated with parents' occupational and environmental exposure to e-waste recycling pollutants. Staining for MT was positive and dense for 67.00% (67/100) of Guiyu neonates as compared with 32.69% (17/52) of controls (p < 0.01). Exposure to e-waste recycling pollutants increased Cd exposure in neonates, which was accompanied by increased placental MT expression.

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Section: Discussionmentioning

confidence: 87%

Assessment of cadmium exposure for neonates in Guiyu, an electronic waste pollution site of China

Huo

Liu

et al. 2010

Environ Monit Assess

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“…Grandjean et al [15] reported that cord blood mercury was a better measure of fetal exposure than maternal blood mercury. Our early studies with limited samples revealed that higher cord blood cadmium level might be associated with a significant decrease in neonatal birth height [16]. Moreover, the relationship between children's IQ and their prenatal cadmium exposure has not been studied.…”

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confidence: 96%

Effects of Gestational Cadmium Exposure on Pregnancy Outcome and Development in the Offspring at Age 4.5 Years

Tian

Zhao

Wang

et al. 2009

Biol Trace Elem Res

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130

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The objective of the present study was to evaluate the potential effect of maternal cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years. Between November 2002 and December 2003, 109 normal pregnant women were enrolled in our cohort from Da-Ye Country, Hubei Province in Central China. The placental, whole blood, and cord blood levels of cadmium were determined by inductively coupled plasma mass spectrometer (ICP-MS). The 106 children at 4.5 years of age given birth by the aforementioned women were followed up and the following rate was 97.25%. Detailed questionnaire surveys, anthropometric measurements were performed, and IQ development was evaluated by Wechsler Preschool and Primary Scale of Intelligence Revised Edition (WPPSI-R). Multiple linear regression analysis indicated that cord blood cadmium level was significantly negatively correlated with fetus development. Low birth weight (less than 2,500 g) occurred significantly more frequently in infants with higher cord blood cadmium than in those exposed to lower levels of cord blood cadmium. Significantly negative correlation was found between cord blood cadmium exposure and WPPSI-R IQ full score after controlling for confounding variables. It was concluded that cord blood cadmium concentration was a factor that influenced fetus growth and later IQ development.

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“…The combination of cadmium's bioavailability, accumulation in the environment, and long biological half-life is only one factor that contributes to maternal exposure and increased risk of FGR. Additionally, clinical studies have reported significantly higher levels of cadmium in the placentas of growth-restricted babies born to smoking mothers (14,25,31,40,45,65). Moreover, animal studies have shown that maternal cadmium exposure leads to FGR (1, 2, 6, 8, 15, …”

Section: Discussionmentioning

confidence: 99%

Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction

Selvaratnam

Guan

Koropatnick

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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Effect of Environmental Exposure to Cadmium on Pregnancy Outcome and Fetal Growth: A Study on Healthy Pregnant Women in China

Cited by 22 publications

References 0 publications

Assessment of cadmium exposure for neonates in Guiyu, an electronic waste pollution site of China

Assessment of cadmium exposure for neonates in Guiyu, an electronic waste pollution site of China

Effects of Gestational Cadmium Exposure on Pregnancy Outcome and Development in the Offspring at Age 4.5 Years

Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction

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