Effect of Enteric Oxygen Therapy on Helicobacteriosis in the Rehabilitation of Children With Chronic Gastroduodenal Pathology

Turdieva, Sh. T.

doi:10.21508/1027-4065-2018-63-4-69-72

Cited by 4 publications

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“…По данным зарубежных учённых Yang Yu., et al (2018), частота выявления Helicobacter pylori-инфекции у детей 7-11 лет с ХГДП превышает 50%, у более старших детей -почти 80% [8]. Как было указанно в нашем предыдущем исследовании [9], клиниколабораторное диагностирование HP-носительства проводилось двумя взаимно несвязанными методами: дыхательным и иммунохроматографическим тестом кала, и данные методы по итогам исследования являются доказательно-обоснованными методами. HP-носительство по уровню показателя относительного риска среди факторов ХГДП имеет -RR=4,84 (CI=4,04-5,79; RRR=3,84; EER=0,75).…”

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The premorbid background and the most significant predictors of the development chronic gastroduodenal pathology in children

Turdieva

2021

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The study features of premorbid background and the most significant predictors of the development of chronic gastroduodenal pathology in children and adolescents of school age. Materials and methods. The results of screening questioning of schoolchildren with chronic gastroduodenal pathology (CGDP) - n=286, and practically healthy schoolchildren - n=1023, from 6 to 15 years agо. The survey conducted according to the questionnaire developed by us, which includes 24 questions. The relative risk (RR) calculated using traditional statistical formulas with a confidence interval limit 95% CI (confidence interval). Results. In this study, it was found that the main nutritional reason for the development of СGDP in schoolchildren is a malnutrition - 69.2%, RR=2.25 (CI=1.81-2.79), and food for fast food - 65.0%, RR=4.19 (CI=3.45-5.09). The least observed was the abuse of spicy food - 4.9%, RR=1.24 (CI=0.80-1.91). The 42.7% of patients were constantly in a state of heightened psychoemotional stress - RR=1.6 (CI=1.32-1.93). Helicobacter pylori (HP) - infection was diagnosed in 57.7% of patients - RR=4.84 (CI=4.04-5.79), 29.0% of patients underwent acute intestinal infections - RR=2.74 (CI=2.29-3.27), and 62.3% had a history of hereditary burden of chronic diseases of the gastrointestinal tract - RR=1.65 (CI=1.34-2.02) Conclusion. The most significant predictors and premorbid backgrounds for the development of СGDP in schoolchildren are HP-infection (RR=4.84; CI=4.04-5.79; RRR=3.84), food for fast food (RR=4.19; CI=3.45-5,09; RRR=3.20) with the development of overweight and obesity (RR=3.64; CI=2.97-4.47; RRR=2.64), the presence of chronic foci of infection (RR=2.58; CI=2.05-3.23; RRR=1.58).

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The premorbid background and the most significant predictors of the development chronic gastroduodenal pathology in children

Turdieva

2021

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“…По результатам нашего исследования у 57,7% пациентов с ХГДП была диагностирована НРинфицированность, следовательно, H. pylori следует считать одним из важных предиктором данной патологии, и на фоне других предикторов патологии [7] ощутима значимость H. pylori в развитии ХГДП у детей и подростков [16,17].…”

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Features of the endoscopic picture in paediatric gastroduodenal diseases caused by Helicobacter pylori

Турдиева

Шамансурова

2020

Russian Journal of Infection and Immunity

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The aim of the study was to examine the features of the endoscopic picture in the upper digestive tract mucosa in paediatric chronic gastroduodenal pathology (CGDP) associated with Helicobacter pylori. Materials and methods. There were examined 286 patients, aged 6–15 years. Diagnostic criteria for chronic gastroduodenal pathology were anamnestic as well as instrumental and functional studies data: gastric fractional intubation, esophagogastroduodenoscopy (EPGDS) with endoscopic pH-metry without biopsy, and ultrasound examination of abdominal organs. H. pylori testing was carried out by two unrelated methods such as respiratory test and a immunochromatographic fecal test. Results. Detection of H. pylori in children with CGDP peaked in patients with peptic gastric and duodenal ulcer (up to 87.5%, p < 0.05). The main endoscopic signs were edema, hyperaemia and contact bleeding, as well as local haemorrhage were the major endoscopic signs of inflammation in the stomach and duodenum mucosa. Atrophic mucosal lesions were characterized by thinning, pale colour together with transilluminated submucosal vessels. Non-atrophic antral gastritis was featured with delayed gastric emptying, antral stasis and pyloric spasm. In contrast, hypotension of the gastric wall, duodenogastric reflux and decreased motility were more typical to chronic atrophic gastritis. Major endoscopic feature in patients with H. pylori infection was presented by dominant atrophic changes combined with gastroduodenal reflux (77.6%, p < 0.05) compared to patients without H. pylori infection. Conclusion. Detection of HP infection was peaked in children with CGDP coupled to peptic ulcer disease compared to patients with inflammatory diseases (p < 0.05). Endoscopic examination in HP-positive patients showed that atrophic changes were found by 4-fold more frequently together with gastroduodenal reflux compared to patients without HP infection (p < 0.05).

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Possibilities of inhalation bacteriophage therapy in treatment of children with acute tonsillitis

2021

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Introduction. At the same time, in the last decade, pediatricians have increased interest in the study of the therapeutic effect of bacteriophages in infectious diseases of rhinolaryngological organs.Objective. The analysis of results of the use of inhalation bacteriophage therapy in children with acute tonsillitis, on an outpatient basis.Materials and methods. Examined 212 children from 4 to 15 years old with acute tonsillitis. Conducted general clinical research, pharyngoscopy, bacteriological examination of a smear of tonsils. Bacteriophage therapy carried out using the Pyobacteriophage complex liquid (PCL).Results. In the course of an objective clinical analysis, on the day of seeking outpatient care, patients noted asthenovegetative disorders in all patients (100%), in the form of general weakness (96.8%), loss of appetite (94.8%), and headache (92.5%). During the examination, cervical lymphadenopathy (98.6%), tonsil hyperemia and hyperplasia (98.1%), and exudates (48.1%) noted. It revealed that the main causative agents of acute tonsillitis in children were the bacteria Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae, with different relative proportions (from 24.2% to 59%). Inhalation bacteriophage therapy carried out from the first days of the disease. Against the background of therapy, it was noted - a decrease in swelling in the tonsils by 2-3 days with a decrease in general intoxication signs. On the 6th day from the beginning of bacteriophage therapy, asthenovegetative disorders stopped 2.2 times faster in relation to patients who did not receive bacteriophage therapy, against the background of a decrease in the manifestation of objective clinical signs of the disease.Conclusion. The use of inhalation bacteriophage therapy as part of the conservative treatment of acute tonsillitis in children contributes 1.4 times to the fastest relief of the acute period and an improvement in the subjective assessment of well-being is 25% higher concerning the comparison group.

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Effect of Enteric Oxygen Therapy on Helicobacteriosis in the Rehabilitation of Children With Chronic Gastroduodenal Pathology

Cited by 4 publications

References 5 publications

The premorbid background and the most significant predictors of the development chronic gastroduodenal pathology in children

The premorbid background and the most significant predictors of the development chronic gastroduodenal pathology in children

Features of the endoscopic picture in paediatric gastroduodenal diseases caused by Helicobacter pylori

Possibilities of inhalation bacteriophage therapy in treatment of children with acute tonsillitis

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