Effect of enteral zinc supplementation on growth and neurodevelopment of preterm infants: a systematic review and meta-analysis

Alshaikh, Belal; Zeed, Moaaz Abo; Yusuf, Kamran; Guin, Madhusudan; Fenton, Tanis R.

doi:10.1038/s41372-021-01094-7

Cited by 9 publications

(7 citation statements)

References 52 publications

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“…A small number of studies suggest an intake of at least 1.4–2 mg/kg/d is needed to achieve optimal growth in preterm infants (125,126) but higher enteral intakes appear safe and may be beneficial. Two recent meta‐analyses suggests that zinc supplementation improves weight gain and linear growth in preterm infants and may decrease mortality (127,128). Very preterm infants can develop symptomatic zinc deficiency with acrodermatitis enterohepatica and/or poor growth, especially those infants who have an enterostomy after NEC surgery (129).…”

Section: Trace Elements (See Supplementary Digital Content Supplement...mentioning

confidence: 99%

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Embleton

Moltu

Lapillonne³

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

125

156

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Objectives: To review the current literature and develop consensus conclusions and recommendations on nutrient intakes and nutritional practice in preterm infants with birthweight <1800 g. Methods: The European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee of Nutrition (CoN) led a process that included CoN members and invited experts. Invited experts with specific expertise were chosen to represent as broad a geographical spread as possible. A list of topics was developed, and individual leads were assigned to topics along with other members, who reviewed the current literature. A single face-to-face meeting was held in February 2020. Provisional conclusions and recommendations were developed between 2020 and 2021, and these were voted on electronically by all members of the working group between 2021 and 2022. Where >90% consensus was not achieved, online discussion meetings were held, along with further voting until agreement was reached. Results: In general, there is a lack of strong evidence for most nutrients and topics. The summary paper is supported by additional supplementary digital content that provide a fuller explanation of the literature and relevant physiology: introduction and overview; human milk reference data; intakes of water, protein, energy, lipid, carbohydrate, electrolytes, minerals, trace elements, water soluble vitamins, and fat soluble vitamins; feeding mode including mineral enteral feeding, feed advancement, management of gastric residuals, gastric tube placement and bolus or continuous feeding; growth; breastmilk buccal colostrum, donor human milk, and risks of cytomegalovirus infection; hydrolyzed protein and osmolality; supplemental bionutrients; and use of breastmilk fortifier. Conclusions: We provide updated ESPGHAN CoN consensus-based conclusions and recommendations on nutrient intakes and nutritional management for preterm infants

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Section: Trace Elements (See Supplementary Digital Content Supplement...mentioning

confidence: 99%

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Embleton

Moltu

Lapillonne³

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

125

156

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“… 36 Another indication is the supplementation for preterm infants (0.5–1 mg/day) up to six months of corrected age, as this supplementation can increase weight gain and linear growth. 37 …”

Section: Zincmentioning

confidence: 99%

Use of dietary supplements by children and adolescents

Barretto,

Gouveia,

Alves

2024

Jornal de Pediatria

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“…Similar effects of weight and height increment and enhancement of serum Zn concentration have been also observed in the meta‐analysis of randomized controlled trials in pre‐pubertal children (Brown et al, 2002). Being a crucial factor for cellular growth, Zn accelerates weight gain and linear growth as seen through the enteral Zn supplementation to infants (Alshaikh et al, 2022). For children below the age of 5 years, a dosage of 10 mg Zn/day for 24 weeks exhibited a growth of 0.37 ± 0.25 cm, as deduced by Imdad and Bhutta in their meta‐analysis conducted on IZiNCG, PubMed database, Cochrane Library, and regional databases of WHO (Imdad & Bhutta, 2011).…”

Section: Strategies For Addressing Zn Deficiencymentioning

confidence: 99%

Zinc nutrition and human health: Overview and implications

Sangeetha

Dutta

Moses

et al. 2022

eFood

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Zinc deficiency, being the fifth leading risk factor for diseases is associated with several disorders and infections, especially diarrhea. The common strategies for sustaining zinc's bioavailability include food fortification, biofortification, supplementation, and dietary diversification. To obtain the best technique, we need to appraise ourselves of the causes of deficiency, zinc bioavailability modalities, potential enhancers as well as inhibitors. This review highlights the role of zinc in human health, its bioavailability, causes and consequences of deficiency, and the strategies to alleviate the deficiency. The strategy of supplementation is pertinent, mostly for the population for whom the usual diet is insufficient for replenishment, and in a short period, the zinc status has to be enhanced. For high-risk groups, fortification could be targeted to prevent potent inhibitors from hindering zinc absorption. By biofortification, enhancement of zinc concentration can be obtained in the edible portion of plants. Germination, fermentation, addition of enhancers, and other processing techniques also help to increase zinc absorption. Dietary modification is found to be an economically feasible, equitable, and sustainable strategy, and can be used to mitigate zinc deficiencies without any antagonistic effect. These strategies should be integrated with health and nutrition programs to create awareness and education, to enhance their sustainability and effectiveness.

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Effect of enteral zinc supplementation on growth and neurodevelopment of preterm infants: a systematic review and meta-analysis

Cited by 9 publications

References 52 publications

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Use of dietary supplements by children and adolescents

Zinc nutrition and human health: Overview and implications

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