Effect of enhanced extracorporeal counterpulsation in patients with non-arteritic anterior ischaemic optic neuropathy

Zhu, Wei; Liao, Ruyi; Chen, Yongchong; Liu, Li; Zhang, Yan

doi:10.1007/s00417-014-2823-z

Cited by 9 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A retrospective analysis of patients with ischemic eye diseases and carotid artery stenosis showed that patients had significant recovery of vision, sight and optic dynamics when managed with pharmacotherapy combined with EECP and that the earlier the treatment was administered, the better . Another study enrolling patients with non‐arteritic anterior ischemic optic neuropathy revealed that EECP increased average flow velocity, peak systolic and end‐diastolic flow of both ophthalmic arteries and central retinal artery, accompanied by improvement in vision and hemodynamic parameters, in which the former was positively correlated with the latter, with greater improvement in the affected side compared with the intact side …”

Section: Other Diseases In the Elderlymentioning

confidence: 99%

“…EECP was first introduced in the treatment of angina and was subsequently applied in various conditions including heart failure, ischemic cerebrovascular diseases and so on, with documented evidence of benefits . Improvements in diabetes, ischemic eye diseases, sudden hearing loss, male erectile dysfunction, sleep disorders, etc have also been reported . As a safe, non‐invasive and effective treatment, EECP has attracted interest from geriatricians who care for elderly with multiple comorbidities.…”

Section: Introductionmentioning

confidence: 99%

“…1-4 Improvements in diabetes, ischemic eye diseases, sudden hearing loss, male erectile dysfunction, sleep disorders, etc have also been reported. [5][6][7][8][9][10] As a safe, non-invasive and effective treatment, EECP has attracted interest from geriatricians who care for elderly with multiple comorbidities. Recent…”

mentioning

confidence: 99%

See 2 more Smart Citations

Expert consensus on the clinical application of enhanced external counterpulsation in elderly people (2019)

Shen

Wang

2020

Aging Medicine

View full text Add to dashboard Cite

Enhanced external counterpulsation (EECP) is a non‐invasive assisted circulation technique and a rich pool of evidence has accumulated for its clinical application in the prevention and management of multiple comorbidities in the elderly population, including angina, heart failure, ischemic cerebrovascular diseases, neurodegenerative diseases, sleep disorder, diabetes and its complications, ischemic eye diseases, sudden hearing loss and erectile dysfunction, as well as various psychological and psychiatric conditions. When applying EECP to elderly patients, emphasis should be placed on issues such as safety assessment, risk management and protocol individualization, as well as the monitoring of efficacy during and after treatment.

show abstract

Section: Other Diseases In the Elderlymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expert consensus on the clinical application of enhanced external counterpulsation in elderly people (2019)

Shen

Wang

2020

Aging Medicine

View full text Add to dashboard Cite

show abstract

“…Therefore, EECP was expected to be a safe and effective intervention in ocualr ischemic diseases. Previously, we reported in 16 NAION patients that visual acuity had improved from 0.92 to 0.40 (LogMAR) after EECP treatment (1 h daily for 12 days) [8]. However, the study did not have a control group.…”

Section: Discussionmentioning

confidence: 90%

Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy

Lin

Zhu

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients. Methods Patients at Zhongshan Ophthalmic Center with recent-onset (<8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment. Results In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59±16.70 days. In the EECP group, the mean EECP duration was 31.57±18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups, regardless of time to treatment initiation. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups. Conclusion This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.

show abstract

“…Using inflatable cuffs around the lower limbs, EECP increases the aortic diastolic pressure and cardiac output by increasing the venous volume return to the heart, leading to increased reperfusion of the affected arteries. Considering the "ischemic nature" of NAION, we previously investigated the use of EECP in NAION patients, which showed promising short-term results in improvement of visual acuity [8]. However, to the best of our knowledge, no controlled study with long-term follow-up and detailed visual function results has been reported regarding the effectiveness of EECP in NAION patients.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy

Lin

Zhu

et al. 2020

BMC Ophthalmol

Self Cite

View full text Add to dashboard Cite

Background: To explore the effects of enhanced external counterpulsation (EECP) and its underlying influencing factors in nonarteritic anterior ischemic optic neuropathy (NAION) patients. Methods: Patients at Zhongshan Ophthalmic Center with recent-onset (< 8 weeks) NAION were retrospectively recruited. The patients had decided whether or not they would undergo EECP treatment, and the patients who declined were included in the control group. The effectiveness of EECP was evaluated by comparing the visual function and fellow eye involvement in patients with and without EECP treatment. Results: In total, 61 patients (76 eyes) were included. Twenty-nine patients (37 eyes) underwent EECP treatment, while 32 patients (39 eyes) were included in the control group. Mean time from NAION onset to EECP initiation was 27.59 ± 16.70 days. In the EECP group, the mean EECP duration was 31.57 ± 18.45 days. EECP was well tolerated by all patients. However, there was no significant difference in visual function between the EECP and control groups. Furthermore, there was no evidence of the effectiveness of EECP in the subgroup analysis of patients with different systemic health conditions. Among the 42 patients with monocular NAION, the sequential attack rate was comparable between the EECP (27.78%) and control (25.00%) groups. Conclusion: This study is the first nonrandomized controlled study to evaluate the effectiveness of EECP in NAION patients. Unfortunately, we failed to demonstrate the effectiveness of EECP in NAION at the 6-month follow-up. Any further application of EECP in NAION patients should be cautious.

show abstract

Effect of enhanced extracorporeal counterpulsation in patients with non-arteritic anterior ischaemic optic neuropathy

Abstract: EECP could be a clinically effective and safe treatment for NAION.

Cited by 9 publications

References 21 publications

Expert consensus on the clinical application of enhanced external counterpulsation in elderly people (2019)

Expert consensus on the clinical application of enhanced external counterpulsation in elderly people (2019)

Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy

Evaluation of enhanced external counterpulsation therapy for nonarteritic anterior ischemic optic neuropathy

Contact Info

Product

Resources

About