Effect of endurance training and/or fish oil supplemented diet on cytoplasmic fatty acid binding protein in rat skeletal muscles and heart

Clavel, Stéphan; Farout, Luc; Briand, M.; Briand, Yves; Jouanel, P

doi:10.1007/s00421-002-0612-6

Cited by 46 publications

(33 citation statements)

References 43 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, these findings are difficult to extrapolate to human insulin resistance because complete genetic H-FABP deficiencies have not been reported. In humans, levels of H-FABP vary in response to numerous physiological and pathological states associated with altered rates of LCFA flux, including chronic exercise training (8), diets supplemented with (-3) polyunsaturated LCFA (9), and weight loss (10). These studies clearly show levels of H-FABP to be dynamic and to fluctuate with LCFA demands.…”

mentioning

confidence: 91%

Partial Gene Deletion of Heart-Type Fatty Acid–Binding Protein Limits the Severity of Dietary-Induced Insulin Resistance

et al. 2005

View full text Add to dashboard Cite

The aim of this study was to determine the contribution of heart-type fatty acid-binding protein (H-FABP) to glucose and long-chain fatty acid (LCFA) utilization in dietaryinduced insulin resistance. We tested the hypothesis that H-FABP facilitates increases in LCFA flux present in glucose-intolerant states and that a partial reduction in the amount of this protein would compensate for all or part of the impairment. Transgenic H-FABP heterozygotes (HET) and wild-type (WT) littermates were studied following chow diet (CHD) or high-fat diet (HFD) for 12 weeks. Catheters were surgically implanted in the carotid artery and jugular vein for sampling and infusions, respectively.

show abstract

mentioning

confidence: 91%

Partial Gene Deletion of Heart-Type Fatty Acid–Binding Protein Limits the Severity of Dietary-Induced Insulin Resistance

et al. 2005

View full text Add to dashboard Cite

show abstract

“…A study by Chang et al indicated that vitamin E influences the training-induced adaptation of glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities in rat skeletal muscle (11); in rats, the deprivation of vitamin E increased the exercise-induced elevation in GPX activity and inhibited exercise-induced SOD activity (14). A study conducted by Baumgartner et al showed that mild oxidative stress led to activation of the intrinsic pathway of apoptosis and death in skeletal muscle cells, which was reduced by supplementation of the culture medium with vitamin E (26).…”

Section: Vitamin E Maintains Skeletal Muscle Which May Slow Down the mentioning

confidence: 99%

“…Various theories on the pathology of osteoarthritis are being investigated that may lead to new therapeutic options. These relate to the role of skeletal muscle (11)(12)(13)(14), the effect of nucleic acid metabolism (15,16), sex gland functions (17)(18)(19), the action of stable mast cells (20,21) and the importance of the subchondral vascular system (9,22,23) in osteoarthritis and its progression. In the present review, the possibility that vitamin E may be able to delay the progression of osteoarthritis was explored through studying the potential role of this nutritional factor in each of these mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E slows down the progression of osteoarthritis

Zhang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Osteoarthritis is a chronic degenerative joint disorder with the characteristics of articular cartilage destruction, subchondral bone alterations and synovitis. Clinical signs and symptoms of osteoarthritis include pain, stiffness, restricted motion and crepitus. It is the major cause of joint dysfunction in developed nations and has enormous social and economic consequences. Current treatments focus on symptomatic relief, however, they lack efficacy in controlling the progression of this disease, which is a leading cause of disability. Vitamin E is safe to use and may delay the progression of osteoarthritis by acting on several aspects of the disease. In this review, how vitamin E may promote the maintenance of skeletal muscle and the regulation of nucleic acid metabolism to delay osteoarthritis progression is explored. In addition, how vitamin E may maintain the function of sex organs and the stability of mast cells, thus conferring a greater resistance to the underlying disease process is also discussed. Finally, the protective effect of vitamin E on the subchondral vascular system, which decreases the reactive remodeling in osteoarthritis, is reviewed.

show abstract

“…Endurance training and/or a fish-oil-supplemented diet can affect cytoplasmic fatty-acid-binding protein (FABP[c]) content in rat skeletal muscles and heart (Clavel, Farout, Briand, Briand, & Jouanel, 2002). After 8 weeks of swimming, 34 trained rats exhibited higher FABP(c) content in the extensor digitorum longus and in the gastrocnemius than did the 32 control rats.…”

Section: Omega-3 Fatty Acids and Exercise Metabolismmentioning

confidence: 99%

“…As a result, both exercise and the omega-3 PUFA-enriched diet influenced FABP(c) content in muscle. These two physiological treatments presumably acted on FABP(c) content by increasing fatty-acid flux within the cell (Clavel et al, 2002). The shift toward a greater use of fat reduces the rate of glycogen depletion and thus fatigue.…”

Section: Omega-3 Fatty Acids and Exercise Metabolismmentioning

confidence: 99%

Omega-3 Polyunsaturated Fatty Acids in Physical Performance Optimization

Mickleborough

2013

International Journal of Sport Nutrition and Exercise Metabolism

View full text Add to dashboard Cite

Increased muscle oxidative stress and inflammatory responses among athletes have been reported consistently. In addition, it is well known that exhaustive or unaccustomed exercise can lead to muscle fatigue, delayed-onset muscle soreness, and a decrement in performance. Omega-3 polyunsaturated fatty acids (PUFAs) have been shown to decrease the production of inflammatory eicosanoids, cytokines, and reactive oxygen species; have immunomodulatory effects; and attenuate inflammatory diseases. While a number of studies have assessed the efficacy of omega-3 PUFA supplementation on red blood cell deformability, muscle damage, inflammation, and metabolism during exercise, only a few have evaluated the impact of omega-3 PUFA supplementation on exercise performance. It has been suggested that the ingestion of EPA and DHA of approximately 1-2 g/d, at a ratio of EPA to DHA of 2:1, may be beneficial in counteracting exercise-induced inflammation and for the overall athlete health. However, the human data are inconclusive as to whether omega-3 PUFA supplementation at this dosage is effective in attenuating the inflammatory and immunomodulatory response to exercise and improving exercise performance. Thus, attempts should be made to establish an optimal omega-3 fatty-acid dosage to maximize the risk-to-reward ratio of supplementation. It should be noted that high omega-3 PUFA consumption may lead to immunosuppression and prolong bleeding time. Future studies investigating the efficacy of omega-3 PUFA supplementation in exercise-trained individuals should consider using an exercise protocol of sufficient duration and intensity to produce a more robust oxidative and inflammatory response.

show abstract

Effect of endurance training and/or fish oil supplemented diet on cytoplasmic fatty acid binding protein in rat skeletal muscles and heart

Cited by 46 publications

References 43 publications

Partial Gene Deletion of Heart-Type Fatty Acid–Binding Protein Limits the Severity of Dietary-Induced Insulin Resistance

Partial Gene Deletion of Heart-Type Fatty Acid–Binding Protein Limits the Severity of Dietary-Induced Insulin Resistance

Vitamin E slows down the progression of osteoarthritis

Omega-3 Polyunsaturated Fatty Acids in Physical Performance Optimization

Contact Info

Product

Resources

About