Effect of Endotoxin Treatment and Tumour Induction on Liver Catalase Activity in Mice

Garcia-Castro, I.; Gaya, Lillian

doi:10.1099/00221287-130-1-119

Cited by 4 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combined action of SOD, CAT, and GSH-Px serves as a potent antioxidant system, but the concentrations of SOD and CAT were not modified by any of the treatments (P > 0.05). Malondialdehyde is the most abundant reactive aldehyde resulting from lactoperoxidase activity and has been widely used as an index of oxidative deterioration of lipids in food and biological samples (Garcia-Castro and Gaya, 1984). In the current study, compared with the saline treatment (P < 0.05), we also found that LPS treatment led to a significantly greater level of MDA, but LPS + Arg treatment decreased that response.…”

Section: Resultssupporting

confidence: 62%

Jugular infusion of arginine has a positive effect on antioxidant mechanisms in lactating dairy cows challenged intravenously with lipopolysaccharide1

Zhao

Wu²,

Zhang

et al. 2018

Journal of Animal Science

View full text Add to dashboard Cite

The main purpose of this work was to evaluate the effects of jugular L-arginine infusion on antioxidant mechanisms in lactating dairy cows challenged intravenously with lipopolysaccharide (LPS). Eight multiparous Holstein cows (609 ± 32 kg) at mid-lactation were randomly assigned to 5-d jugular infusions of Control (saline), Arginine (Arg, 18 g/d), LPS (0.2 μg/kg BW per d), and LPS + Arginine (0.2 μg/kg BW per d of LPS and 18 g/d of Arg) in a replicated 4 4 Latin square design with 4 infusion periods separated by 10-d. Jugular solutions of saline, Arg, LPS, and LPS + Arg were continuously infused using peristaltic pumps for approximately 6 h/d. Jugular vein serum samples were obtained on the last day of each infusion period before infusion (0 h) and at 3 and 6 h post-infusion. Compared with LPS treatment, Arg infusion increased the total antioxidant capacity and activity of glutathione peroxidase, but decreased malonaldehyde concentration (P < 0.05). The concentration of nitric oxide in serum and the activity of nitric oxide synthase were greater in LPS treatment compared with saline and Arg (P < 0.05). The Arg treatment significantly increased the serum insulin concentration at 3 h post-infusion compared with the saline treatment (P < 0.05), and that of LPS and LPS + Arg treatments were in between Arg and LPS treatments. No treatment effect was observed on the activities of superoxide dismutase and catalase (P > 0.05). In conclusion, enhancing the supply of Arg during an inflammatory challenge enhances antioxidant mechanisms in lactating dairy cows.

show abstract

Section: Resultssupporting

confidence: 62%

Jugular infusion of arginine has a positive effect on antioxidant mechanisms in lactating dairy cows challenged intravenously with lipopolysaccharide1

Zhao

Wu²,

Zhang

et al. 2018

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…Low-dose LPS administration caused significant decreases in kidney CAT mRNA, with no effect on CAT activity or mRNA in heart or liver. (38) A 40-mg LPS dose significantly reduced liver CAT activity in vivo 16 h after LPS administration, (39) and administration of 8 mg/kg LPS decreased CAT activity 24, 48, and 72 h after LPS administration. (3) Dhaunsi et al (40) suggested post-translational mechanisms of decreasing CAT activity by demonstrating increases in peroxisomal CAT protein with decreased CAT activity, in peroxisomes of liver homogenates after LPS administration.…”

Section: Discussionmentioning

confidence: 94%

Cytochrome P450 and Antioxidant Activity in Interleukin-6 Knockout Mice After Induction of the Acute-Phase Response

Warren

Ess

Watson

et al. 2001

Journal of Interferon & Cytokine Research

View full text Add to dashboard Cite

Hepatic cytochrome P450 (CYP) expression and antioxidant activity have been shown to decrease following endotoxin (lipopolysaccharide [LPS]) or proinflammatory cytokine administration. Using mice deficient in interleukin-6 (IL-6), the role of IL-6 in the regulation of hepatic CYP activity, glutathione (GSH) metabolism, and catalase (CAT) activity was analyzed after LPS administration. Administration of LPS produced comparable decreases in hepatic CYP3A activity in WT B6x129 (WT) mice and IL-6 knockout mice. No decrease was observed for CYP2D9 activity after LPS administration in either WT or IL-6 knockout mice. LPS administration significantly increased hepatic and renal CYP2E1 and CYP4A activity in WT mice, with no effect in IL-6 knockout mice. CYP2A12 activity increased in IL-6 knockout, mice with no change in WT mice after LPS administration. LPS administration had no significant effect on hepatic GSH reductase, GST peroxidase, GSH-S-transferase (GST), or total GSH in either WT or IL-6 knockout. However, hepatic CAT activity was significantly reduced in WT mice after LPS administration, with no effect in IL-6 knockout mice. These results support IL-6 as a critical mediator of the effects of LPS on specific hepatic and renal CYP activities and hepatic CAT activity.

show abstract

“…Garcia-Castro and Gaya (1984); Spolarics et al (1996) and Spolarics and Wu (1997). The latter suggested that the recorded decrease in catalase activity may be due to enzyme inactivation by its own substrate.…”

Section: Discussionmentioning

confidence: 88%

Immunomodulating effect of inositol hexaphosphate against Aeromonas hydrophila-endotoxin

Abuelsaad

2007

Immunobiology

View full text Add to dashboard Cite

Effect of Endotoxin Treatment and Tumour Induction on Liver Catalase Activity in Mice

Cited by 4 publications

References 6 publications

Jugular infusion of arginine has a positive effect on antioxidant mechanisms in lactating dairy cows challenged intravenously with lipopolysaccharide1

Jugular infusion of arginine has a positive effect on antioxidant mechanisms in lactating dairy cows challenged intravenously with lipopolysaccharide1

Cytochrome P450 and Antioxidant Activity in Interleukin-6 Knockout Mice After Induction of the Acute-Phase Response

Immunomodulating effect of inositol hexaphosphate against Aeromonas hydrophila-endotoxin

Contact Info

Product

Resources

About