Effect of endothelial and adventitial injury on somatostatin receptor expression

Expression of somatostatin receptors in splanchnic blood vessels of normal and cirrhotic rats

“…In these tissues, the RTQ experiments were successful, meaning that there was no fundamental problem with the assay. This is in accordance with previous studies, in which SSTR5 was undetectable by QRT‐PCR in rat and human arteries (13, 21). In another study, SSTR5 was absent in normal aorta, and was barely detectable following vascular injury (14).…”

“…In another study, SSTR5 was absent in normal aorta, and was barely detectable following vascular injury (14). It has been described that SSTR expression is altered following vascular trauma (13, 14). In our model, the mRNA expression of SSTRs was quite similar in normal and in cirrhotic rats, as well as in the portal vein, the mesenteric artery and the aorta.…”

TNF-α decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells

“…The effect of SST or its analogues on cell proliferation can be directly via five subtypes of SSTRs or indirectly through the influence of the release of growth factors and trophic hormones [14,15]. SST is an inhibitor of tumor cell growth and its analogues are also used as powerful antitumor agents in vivo [16,17].…”

Somatostatin: A Hormone for the Heart?

“…Molecular biology and pharmacologic studies have shown that SRIF receptor subtypes are expressed in intact and isolated vascular smooth muscle cells of rat and human, as well as in transformed and normal human endothelial cell lines [44,56,59,60]. Rodent models of vascular injury have suggested that SRIF receptors may be responsible for suppressing injury-mediated smooth muscle cell growth [56,60]. Molecular studies have supported this notion and have shown that injury-induced SRIF receptor expression is increased in the vasculature in a subtype and time-dependent fashion with sst 1 , sst 3 and sst 4 being up-regulated in post injury [60].…”

“…SRIF has broad effects within the vasculature with direct effects on vascular smooth muscle cells [54][55][56] and a modulation of peripheral blood flow [57]. In the smooth muscle cells that underlie the vascular beds, SRIF modulates Ca 2+ conductance and cyclic nucleotides to cause contraction of the smooth muscle cells, thereby restricting blood flow [47,58].…”