Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis

Wang, Shengming; Wang, Xiaoqing; Bai, Feng; Shi, Xinlian; Zhou, Tingting; Li, Fangfang

doi:10.1016/j.heliyon.2023.e13914

Cited by 4 publications

(7 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In sum, our results indicate a clinical benefit of RCT in patients with AP and UTL A1c, as RCT might contribute to a modest reduction in HbA1c control, comparable to that of daily intake of antidiabetic drugs, and therefore to complication reduction. Rudranaik et al (2016) and Wang et al (2023) have reported results similar to ours. Opposite results have been stated by Arya et al (2017).…”

Section: Discussionsupporting

confidence: 88%

“…Taking into account the linkage between T2DM and AP as inflammatory diseases (Georgiou et al, 2019), the reported effects of RCT on glycaemia are ambiguous. Thus, Arya et al (2017) has shown that RCT did not improve HbA1c level in patients with T2DM, and Wang et al (2023) found a significant reduction of HbA1c 6-month after RCT in T2DM and control patients.…”

Section: Introductionmentioning

confidence: 97%

“…Considering that the healing of AP is a long‐lasting process, longitudinal and prospective clinical trials may provide an accurate estimation of T2DM effects on the periapical healing. Up to date, only a few prospective studies have investigated the effects of T2DM on the RCT outcome, all showing lower healing rate of RCT in T2DM patients as compared to control subjects (Arya et al., 2017; Rudranaik et al., 2016; Wang et al., 2023). Outcome of RCT in T2DM patients has been suggested to depend on the glycaemic control (Nagendrababu et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of apical periodontitis treatment on hyperglycaemia in diabetes: A prospective cohort study

Davidović,

Krunić,

Mladenović

et al. 2024

Int Endodontic J

View full text Add to dashboard Cite

AimThis prospective cohort study was undertaken to evaluate the success rate of root canal treatment (RCT) in type 2 diabetes mellitus (T2DM) patients with targeted level and unachieved targeted level of glycaemic control as well as the impact of RCT on the glucose blood level in T2DM patients.MethodologyPatients needing RCT were divided into three groups: these without T2DM, that is, the control group (CG), those with targeted level of glycated haemoglobin HbA1c < 7% (TL A1c) and the third ones with unachieved targeted level (UTL A1c), that is, with HbA1c ≥ 7%. Before RCT, HbA1c and the periapical index (PAI) score were assessed, as well as 1 year later.ResultsOur results showed less favourable treatment results of RCT such as a reduction of radiographic lesions in T2DM patients, particularly in subjects with UTL A1c. The intergroup analysis of PAI score at the 12‐month follow‐up revealed a significant difference in TL A1C (p = .022) and CG (p = .001) with respect to UTL A1c. Total number of healed teeth (PAI≤2) at the 12‐month after RCT in UTL A1c was significantly lower in comparison to CG (p = .008). Contrariwise, RCT may improve the glycaemic control in diabetic patients with UTL A1c after 12 months of posttreatment. Regression analysis showed that UTL A1c patients were more likely to have AP persistence after endodontic treatment (OR = 4.788; CI: 1.157–19.816; p = .031).ConclusionsT2DM retards the AP healing and conversely AP contributes to increasing the inflammatory burden in T2DM. RCT reduces the cumulative inflammatory burden in T2DM and thus may contribute to improvement of glycaemic control particularly in patients with UTL A1c.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of apical periodontitis treatment on hyperglycaemia in diabetes: A prospective cohort study

Davidović,

Krunić,

Mladenović

et al. 2024

Int Endodontic J

View full text Add to dashboard Cite

show abstract

“…In some immunocompromised patients, such as those with diabetes, the resolution of AP is delayed. In fact, among immunocompromised patients, there is an increase in the prevalence of periodontal disease in teeth with endodontic infection and a decrease in the success of endodontic treatment in teeth with preoperative AP [ 35 , 36 ]. Furthermore, genetic factors that control the host immune response have also been shown to influence the resolution of permanent chronic AP.…”

Section: Contemporary Therapiesmentioning

confidence: 99%

Recent Advances in Apical Periodontitis Treatment: A Narrative Review

et al. 2023

View full text Add to dashboard Cite

Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of the tooth. The most conservative approach to treat this condition is nonsurgical endodontic treatment. However, clinical failure has been reported with this approach; thus, alternative procedures are required. This review highlights recent literature regarding advanced approaches for the treatment of apical periodontitis. Various therapies, including biological medications, antioxidants, specialized pro-resolving lipid mediators, and stem cell therapy, have been tested to increase the success rate of treatment for apical periodontitis. Some of these approaches remain in the in vivo phase of research, while others have just entered the translational research phase to validate clinical application. However, a detailed understanding of the molecular mechanisms that occur during development of the immunoinflammatory reaction in apical periodontitis remains unclear. The aim of this review was to summarize advanced approaches for the treatment of apical periodontitis. Further research can confirm the potential of these alternative nonsurgical endodontic treatment approaches.

show abstract

“…While the success of this treatment has typically been attributed to instrumentation, disinfection and obturation, recent research suggests that systemic diseases can also play a role in determining treatment outcomes (1). Diabetes mellitus, a metabolic disorder characterized by blood sugar levels (hyperglycemia) has been identified as one such systemic factor that can affect endodontic outcomes (2,3). The immune response of individuals may be compromised, which can hinder the resolution of infections and contribute to persistent or recurring endodontic issues (4,5).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Systemic Diseases on Endodontic Treatment Outcomes

Qasim,

Al-Hajji,

Almutairy

et al. 2023

JOHS

View full text Add to dashboard Cite

Endodontic treatment is vital for preserving teeth as it involves removing pulp tissue and sealing the root canal system. Individuals with compromised function may present with aggressive forms of periapical lesions, which can complicate treatment approaches. Strict infection control measures are crucial during procedures for immunocompromised patients due to the increased risk of infections. This review discusses the connection between diseases and endodontic treatment outcomes. It sheds light on how conditions like diabetes, cardiovascular diseases, immunocompromised states, and osteoporosis can affect manifestations and management strategies. The clinical landscape presents challenges, such as delayed healing and persistent lesions in diabetes due to compromised responses to tissue repair issues caused by vascular changes in cardiovascular diseases, atypical periapical lesions in immunocompromised states, and compromised bone healing in osteoporosis. Managing these conditions requires an approach that puts the patient at the center. It involves monitoring, infection control measures, collaborating with specialists, and making decisions together with the patient. These insights emphasize the importance of endodontic practitioners considering health factors when planning treatments to achieve outcomes.

show abstract

Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis

Cited by 4 publications

References 46 publications

Effects of apical periodontitis treatment on hyperglycaemia in diabetes: A prospective cohort study

Effects of apical periodontitis treatment on hyperglycaemia in diabetes: A prospective cohort study

Recent Advances in Apical Periodontitis Treatment: A Narrative Review

The Impact of Systemic Diseases on Endodontic Treatment Outcomes

Contact Info

Product

Resources

About