Effect of Emollients Containing Vegetable-Derived<i>Lactobacillus</i>in the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial

Park, Seung Bae; Im, Myung; Lee, Young; Lee, Jeung Hoon; Lim, Jeong Heui; Park, Yong Ha; Seo, Young‐Joon

doi:10.5021/ad.2014.26.2.150

Cited by 32 publications

(26 citation statements)

References 20 publications

(31 reference statements)

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“…Skin emollients are a critical component of AD treatment because they rehydrate the skin, improve the skin barrier function [ 17 – 19 ], and reduce the severity of AD [ 18 , 20 ]. Furthermore, emollients may prevent the development of eczema in infants at high risk for AD when used regularly in the first six months of life [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis

et al. 2018

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BackgroundEmollients are a mainstay of treatment in atopic dermatitis (AD), a disease distinguished by skin bacterial dysbiosis. However, changes in skin microbiota when emollients are used as a potential AD preventative measure in infants remain incompletely characterized.ResultsWe compared skin barrier parameters, AD development, and bacterial 16S ribosomal RNA gene sequences of cheek, dorsal and volar forearm samples from 6-month-old infants with a family history of atopy randomized to receive emollients (n = 11) or no emollients (controls, n = 12). The emollient group had a lower skin pH than the control group. The number of bacterial taxa in the emollient group was higher than in the control group at all sites. The Streptococcus salivarius proportion was higher in the emollient versus control groups at all sites. S. salivarius proportion appeared higher in infants without AD compared to infants with AD. A decrease in S. salivarius abundance was further identified in a separate larger population of older children demonstrating an inverse correlation between AD severity at sampling sites and S. salivarius proportions.ConclusionsThe decreased skin pH and the increased proportion of S. salivarius after long-term emollient use in infants at risk for developing AD may contribute to the preventative effects of emollients in high-risk infants.

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Section: Introductionmentioning

confidence: 99%

Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis

et al. 2018

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“…Restoration of the normal skin barrier function by emollient use can down-regulate inflammation and reduce the symptoms and flares of AD 15 . Additionally, regular use of emollient may also reduce the need for topical corticosteroid by 50% 16 . Consequently, regular use of emollient is important in AD management.…”

Section: Discussionmentioning

confidence: 99%

Effects of Emollient Containing Bee Venom on Atopic Dermatitis: A Double-Blinded, Randomized, Base-Controlled, Multicenter Study of 136 Patients

et al. 2016

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BackgroundAtopic dermatitis (AD) is a common, complex disease that follows a chronic relapsing course and significantly affects the quality of life of patients. Skin barrier dysfunction and inflammatory processes induce and aggravate this skin condition. Proper use of an emollient for hydration is a keystone of AD treatment. Bee venom is known to have anti-inflammatory effects and has been widely used in traditional medicine to treat various inflammatory disorders.ObjectiveTo find out the beneficial effect of an emollient containing bee venom in the treatment of patients with AD.MethodsThis study included 136 patients with AD who were randomized to receive either an emollient containing bee venom and silk-protein or a vehicle that was identical except for the bee venom for 4 weeks. The patients were instructed to apply the emollient twice daily on their entire body and not to use other medications, including topicals, during the course of the study. The eczema area and severity index (EASI) score, transepidermal water loss, and visual analogue scale (VAS) score of itching were evaluated at the first visit and after 2 and 4 weeks. The investigator global assessment was evaluated at 2 and 4 weeks after the application of emollient containing bee venom or vehicle.ResultsPatients applying emollient containing bee venom showed significantly lower EASI score and VAS value compared to patients applying emollient without bee venom.ConclusionEmollient containing bee venom is a safe and effective option for patients with AD.

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“…In 16 subjects with xerosis, application of Lactobacillus brevis ‐containing ointment for 4 weeks significantly decreased transepidermal water loss (TEWL), decreased xerosis, and increased commensal bacterial colonization compared to vehicle (Holz et al, ). Application of Lactobacillus sakei‐ containing emollient significantly decreased pruritus and TEWL in 28 AD subjects (Park et al, ). Only three subjects in either study experienced treatment‐related adverse effects, reporting self‐limited mild application site reactions.…”

Section: Microbiome Modulatorsmentioning

confidence: 99%

Bioactive: A new era of bioactive ingredients in topical formulations for inflammatory dermatoses

Yang

Hendricks

Beck

et al. 2019

Dermatologic Therapy

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Moisturization is the pillar of daily skin care and has significant benefit in improving hydration, strengthening the skin barrier, and ameliorating inflammatory dermatoses. Bioactive ingredients such as endocannabinoids, bioactive lipids, growth factors, microbiome modulators, and antioxidant enzymes are increasingly being incorporated into moisturizer formulations. These novel ingredients have been shown to improve skin barrier function, upregulate barrier lipid synthesis, decrease itch and inflammation, and have antioxidative properties. In this article, we highlight evidence supporting their mechanisms of action and efficacy in atopic dermatitis, uremic pruritus, asteatotic eczema, acne vulgaris, and vitiligo.

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Effect of Emollients Containing Vegetable-DerivedLactobacillusin the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial

Cited by 32 publications

References 20 publications

Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis

Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis

Effects of Emollient Containing Bee Venom on Atopic Dermatitis: A Double-Blinded, Randomized, Base-Controlled, Multicenter Study of 136 Patients

Bioactive: A new era of bioactive ingredients in topical formulations for inflammatory dermatoses

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