1984
DOI: 10.1159/000281002
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Effect of Emepronium Bromide (Cetiprin®) on Symptoms and Urinary Bladder Function after Transurethral Resection of the Prostate

Abstract: 75 patients were randomized to be treated with either emepronium bromide (Cetiprin®) 200 mg 4 times a day or placebo after transurethral resection of the prostate. The patients were evaluated urodynamically pre- and postoperatively, and further evaluated by micturition symptom charts. No significant differences in symptoms or objective findings were found between the patients treated with emepronium bromide and those treated with placebo.

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Cited by 7 publications
(3 citation statements)
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“…Several studies have supported that antimuscarinics can depress involuntary bladder contractions (Low 1977, Cardozo and Stanton 1979, Blaivas et al 1980, Naglo et al 1981). On the other hand, there are several reports of insufficient efficacy of antimuscarinics given orally to patients with unstable detrusor contractions (Ritch et al 1977, Walther et al 1982, Bonnesen et al, 1984, Zorzitto et al 1986. It is unclear to what extent this can be attributed to low bioavailability of the drugs used, side effects limiting the dose that can be given, or to atropine resistance.…”
Section: Antimuscarinic (Anticholinergic) Drugsmentioning
confidence: 99%
“…Several studies have supported that antimuscarinics can depress involuntary bladder contractions (Low 1977, Cardozo and Stanton 1979, Blaivas et al 1980, Naglo et al 1981). On the other hand, there are several reports of insufficient efficacy of antimuscarinics given orally to patients with unstable detrusor contractions (Ritch et al 1977, Walther et al 1982, Bonnesen et al, 1984, Zorzitto et al 1986. It is unclear to what extent this can be attributed to low bioavailability of the drugs used, side effects limiting the dose that can be given, or to atropine resistance.…”
Section: Antimuscarinic (Anticholinergic) Drugsmentioning
confidence: 99%
“…Therefore it may be that abnormalities in Ca 2+ channel function in the detrusor muscle play an important role in detrusor instability. Consistent with this idea is the fact that anticholinergic drugs, which have been widely prescribed for the treatment of urinary incontinence, have been reported to be only modestly effective (Walter et al 1982;Bonnesen et al 1984;Zorzitto et al 1986). Therefore, drugs with both anticholinergic and Ca 2+ antagonistic activities may be more effective for the treatment of hypercontractility in detrusor smooth muscle than drugs with anticholinergic activity only.…”
Section: Introductionmentioning
confidence: 94%
“…Several studies have supported the theory that antimuscarinics can depress involuntary bladder contractions [22][23][24][25]. On the other hand, there are several reports of insufficient efficacy of antimuscarinics given orally to patients with DO [26][27][28][29]. It is unclear to what extent this can be attributed to the low bioavailability of the drugs used, side effects limiting the dose that can be given, or a resistance phenomenon.…”
Section: Antimuscarinic (Anticholinergic) Drugsmentioning
confidence: 99%